Search Result

Search Results for " cell-cycle-arrest "

Targets

GSK-3 MAPK DYRK Akt Chk Bcr-Abl CDK S6 Kinase Aurora Kinase

305

Compounds

Natural Products

Recombinant Proteins

Libraries

Cat No.	Product Name	Synonyms	Targets
T11960	MBM-55		GSK-3 , MAPK , DYRK , Akt , Chk , Bcr-Abl , CDK , S6 Kinase , Aurora Kinase
	MBM-55 is an effective inhibitor of NIMA related kinase 2 (NEK2) with an IC50 of 1 nM. MBM-55 effectively inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis.
T14066	9-ING-41		Apoptosis , GSK-3 , Autophagy
	9-ING-41 is a glycogen synthase kinase-3 inhibitor.		Apoptosis , GSK-3 , Autophagy
T23133	Pentamidine		Phosphatase , Antibacterial , Antibiotic , Parasite , Antifungal
	Pentamidine is an antifungal and antiprotozoal agent, interacting directly with the pathogen genome by binding to AT-rich regions of duplex DNA and the minor groove of DNA, thereby interfering with DNA replication.
T6207	SC144		Apoptosis , Interleukin
	SC144 is an orally active small-molecule gp130 inhibitor.		Apoptosis , Interleukin
T22461	YKL-5-124		CDK
	YKL-5-124, a potent, selective and covalent CDK7 inhibitor with an IC50 of 9.7 nM, 1300 nM and 3020 nM for CDK7/Mat1/CycH, CDK2 and CDK9 respectively, displays biochemical and cellular selectivity for CDK7 over CDK12/13...		CDK
T15012	Crolibulin	EPC2407	Microtubule Associated
	Crolibulin (EPC2407) is an inhibitor of small molecule tubulin polymerization.		Microtubule Associated
T36816	S-trityl-L-Cysteine	STLC	Kinesin
	S-trityl-L-Cysteine is a non-natural amino acid and an inhibitor of Eg5, also known as KSP and Kif11, a mitotic kinesin necessary for mitotic spindle formation. S-trityl-L-Cysteine inhibits the ATPase activity of Eg5 in ...		Kinesin
T6303	CCT128930		Akt , PKA , S6 Kinase , Autophagy
	CCT128930 is a potent, ATP-competitive and selective inhibitor of Akt2 with IC50 of 6 nM, 28-fold greater selectivity for Akt2 than the closely related PKA kinase.		Akt , PKA , S6 Kinase , Autophagy
T10460	Batabulin	T138067	Apoptosis , Microtubule Associated
	Batabulin (T138067) is an antitumor compound, which binds covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization. Batabulin affects cell morphology and leads to ce...		Apoptosis , Microtubule Associated
T1654	Pentamidine isethionate	Pentamidine isethionate salt,Pentamidine diisethionate	Phosphatase , Antibacterial , Antibiotic , Parasite , Antifungal
	Pentamidine isethionate (Pentamidine diisethionate) is a synthetic amidine derivative, Pentamidine Isethionate is an antiprotozoal and antifungal agent.
T2641	KRCA-0008	KRCA 0008,KRCA0008	ACK , ALK
	KRCA-0008 is an effective and specific ALK/Ack1 inhibitor (IC50: 12/4 nM); displays drug-like properties without hERG liability.		ACK , ALK
T4215	TCS-PIM-1-4a	SMI-4a	Apoptosis , Pim
	TCS-PIM-1-4a (SMI-4a), a Pim inhibitor, blocks mTORC1 activity through activation of AMPK and kills a wide range of both myeloid and lymphoid cell lines (IC50=0.8-40 μM).		Apoptosis , Pim
T4134	OTS514 hydrochloride	OTS-514 hydrochloride,OTS514 hydrochloride(1338540-63-8(free base))	Apoptosis , TOPK
	OTS514 hydrochloride is a highly effective TOPK(T-LAK cell-originated protein kinase) inhibitor (IC50: 2.6 nM).		Apoptosis , TOPK
T23132	Pentamidine dihydrochloride	MP-601205 dihydrochloride	Phosphatase , Antibacterial , Antibiotic , Parasite , Antifungal
	Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an aromatic diamidine agent with activity against a number of microorganisms including protozoa (Trypanosoma brucei, Leishmania spp., and Babesia spp.) and fungi...
T6303L	CCT128930 hydrochloride	CCT128930 hydrochloride(885499-61-6 Free base)	Apoptosis , Akt , PKA , mTOR , Autophagy
	CCT128930 hydrochloride (CCT128930 hydrochloride) is a potent and selective inhibitor of AKT with IC50 of 6 nM. CCT128930 hydrochloride induces cell cycle arrest, DNA damage, and autophagy. CCT128930 hydrochloride has 28...		Apoptosis , Akt , PKA , mTOR , Autophagy
T2241	Alisertib	MLN 8237	Apoptosis , Aurora Kinase , Autophagy
	Alisertib (MLN 8237) is a specific Aurora A inhibitor (IC50: 1.2 nM). The selectivity of Alisertib(MLN 8237) is >200-fold higher for Aurora A than Aurora B.		Apoptosis , Aurora Kinase , Autophagy
T2170	SKF-96365 hydrochloride	SKF96365	Apoptosis , Potassium Channel , Calcium Channel , TRP/TRPV Channel , Autophagy
	SKF-96365 hydrochloride (SKF96365) , a SOCE inhibitor, exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal Y cells. SKF-96365 hydrochloride can induce cytoprotective autopha...
T4134L	OTS514	OTS514 HCl,OTS514 Hydrochloride,OTS-514,OTS 514	Apoptosis , TOPK
	OTS514 (OTS514 Hydrochloride) is a potent TOPK inhibitor. OTS514 exhibits a growth-suppressive effect on small cell lung cancer. OTS514 effectively suppressed the growth of SCLC cell lines (IC50: 0.4 ~ 42.6 nM). Treatmen...		Apoptosis , TOPK
T10343	AOH1160	N-(2-Oxo-2-(2-phenoxyphenylamino)ethyl)-1-naphthamide	Apoptosis , DNA/RNA Synthesis
	AOH1160 is an inhibitor of proliferating cell nuclear antigen (PCNA). AOH1160 induces apoptosis and causes cell-cycle arrest by interfering with DNA replication.		Apoptosis , DNA/RNA Synthesis
T9712	PF07104091	PF-07104091	CDK
	PF07104091 inhibits CDK2, which may lead to cell cycle arrest, induce apoptosis and inhibit tumor cell proliferation.		CDK
T2425	KPT185	KPT-185,KPT 185	CRM1
	KPT185 (KPT 185) is a selective CRM1 inhibitor, inducing apoptosis, cell-cycle arrest.		CRM1
T6844	GGTI298 Trifluoroacetate	GGTI 298,GGTI 298 TFA salt	Apoptosis , Transferase , Ras
	GGTI298 Trifluoroacetate (GGTI 298 TFA salt) is a geranylgeranyltransferase I inhibitor with ability to arrest human tumor cells in the G1 phase of the cell cycle and induce apoptosis.		Apoptosis , Transferase , Ras
T2615	Flavopiridol hydrochloride	Alvocidib Hydrochloride,NSC 649890,MDL 107826A,HL 275,FLAVOPIRIDOL HCL,NSC 649890 HCl	HIV Protease , CDK , Autophagy
	Flavopiridol hydrochloride (MDL 107826A) is a synthetic N-methylpiperidinyl chlorophenyl flavone compound. As an inhibitor of cyclin-dependent kinase, alvocidib induces cell cycle arrest by preventing phosphorylation of ...		HIV Protease , CDK , Autophagy
T34262	RAPTA-C		Apoptosis
	RAPTA-C induces EAC cell cycle arrest and apoptosis via the mitochondrial and p53-JNK pathways, and can be used in the study of breast and ovarian cancer.		Apoptosis
T10268	AGX51		Others
	AGX51 is an antagonist of inhibitor of DNA binding (ID) proteins. AGX51 treatment lead to pan-Id degradation, cell cycle arrest, and cell death.		Others
T0975	Chlorambucil	CB-1348,Chloroambucil,WR-139013	DNA Alkylator/Crosslinker , DNA Alkylation
	Chlorambucil (CB-1348) is an orally-active antineoplastic aromatic nitrogen mustard. Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arr...		DNA Alkylator/Crosslinker , DNA Alkylation
T17187	TZ9		Apoptosis , E1/E2/E3 Enzyme
	TZ9 is a selective and potent Rad6 inhibitor with anticancer and anti-tumor activity.TZ9 inhibits Rad6B-induced ubiquitination of histone H2A.TZ9 induces cell cycle arrest and apoptosis.		Apoptosis , E1/E2/E3 Enzyme
T4189	4-Oxofenretinide	3-Keto fenretinide	cell cycle arrest
	4-Oxofenretinide (3-Keto fenretinide) , a recently identified fenretinide metabolite, induces marked G2-M cell cycle arrest and apoptosis.		cell cycle arrest
T3485	Probimane	AT-2153,MM-159	Others
	Probimane (AT-2153) had Anti-proliferative effects, cell cycle G2/M phase arrest and blocking of chromosome segregation in human tumor cell lines with MST-16.		Others
T77667	PI3Kδ-IN-16		Apoptosis , PI3K
	PI3Kδ-IN-16 is a selective and potent PI3Kδ inhibitor with anticancer and antiproliferative activity, induces cell cycle arrest and apoptosis.		Apoptosis , PI3K
T19699	Triciribine phosphate	TCN-P,VD 002,VQD-002	Apoptosis , Akt
	Triciribine phosphate (VD 002) is a highly selective AKT inhibitor that induces cell cycle arrest and cysteinyl asparagin-dependent apoptosis, inhibits neovascularization, and can be used in the study of leukemia.		Apoptosis , Akt
T77647	Tubulin polymerization-IN-43		Apoptosis , Microtubule Associated
	Tubulin polymerization-IN-43 is an inhibitor of tubulin polymerisation.Tubulin polymerization-IN-43 has multiple effects, disrupting the cellular microtubule network by targeting the colchicine locus and promoting cell c...		Apoptosis , Microtubule Associated
T36898	Sandacanol	Sandranol,2-Ethyl-4-(2,2,3-trimethylcyclopent-3-en-yl)-but-2-en-1-ol	Apoptosis
	Sandacanol（Sandranol） is a selective olfactory receptor (OR10H1) agonist. Sandacanol can induce cell cycle arrest and partial apoptosis in bladder cancer cells, and can reduce cell migration rate and proliferation rate.		Apoptosis
T19831	Sodium Oxamate	oxamate sodium,Oxamic acid sodium salt,Aminooxoacetic acid sodium salt,SO	Apoptosis , Dehydrogenase , CDK
	Sodium Oxamate (Oxamic acid sodium salt) is an LDH inhibitor that specifically inhibits LDHA. Sodium Oxamate has antitumor activity and induces cell cycle arrest and apoptosis.		Apoptosis , Dehydrogenase , CDK
T73515	MC2590		Apoptosis , HDAC
	MC2590 is a potent and selective histone deacetylase (HDAC) inhibitor that inhibits HDAC1-3, -6, -8, and -10 activities, induces cell cycle arrest, and promotes apoptosis.		Apoptosis , HDAC
T3048	10058-F4	c-Myc Inhibitor	c-Myc , Autophagy
	10058-F4 (c-Myc Inhibitor) is a cell-permeable thiazolidinone that specifically inhibits the c-Myc-Max interaction and prevents transactivation of c-Myc target gene expression; induces cell-cycle arrest and apoptosis.		c-Myc , Autophagy
T1844	KPT330,(E)-	(E)-RN,KPT-330,KPT330,KPT 330	Others , CRM1
	(E)-RN (KPT 330) is a CRM1-selective inhibitor of nuclear export. It inhibits protein trafficking from the nucleus and induces cell cycle arrest and apoptosis in mesothelioma cells.		Others , CRM1
T11718	JI051	JI-051	Gamma-secretase
	JI051 is an antitumor agent that interacts with the cancer-associated protein chaperone prohibitin 2 (PHB2) to induce cell cycle arrest by inhibiting the transcription of the Notch downstream effector gene, Hes1, and inh...		Gamma-secretase
T61722	ZDLD20
	ZDLD20 is a β-carboline compound that functions as an orally active and selective CDK4/CycD3 inhibitor, with an IC50 value of 6.51 μM. It demonstrates significant anti-HCT116 activity, including inhibition of colony form...
T67741	SU056		Others
	SU056 is a YB-1 inhibitor. SU056 interacts with YB-1 and inhibits and downstream proteins and pathways. SU056 can induce cell-cycle arrest, apoptosis, and inhibit cell migration in ovarian cancer cells.		Others
T6970	RK33	RK-33,RK 33	COX
	RK33 (RK 33) is a first-in-class small molecule inhibitor of DDX3 (a RNA helicase) and causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sensitization in DDX3-overexpressing cells.		COX
T5618	AK-1		Sirtuin
	AK-1 is a sirtuin 2 (SIRT2) inhibitor (IC50:12.5 µM).that prevents hippocampal neurodegeneration in Alzheimer's disease models and induces cell cycle arrest in colon carcinoma cells.		Sirtuin
T24212	XX-650-23	XX65023,XX 650 23	Apoptosis , Epigenetic Reader Domain
	XX-650-23 is a small molecule CREB inhibitor that blocks the critical interaction between CREB and its required coactivator, CBP (CREB-binding protein), inducing apoptosis and cell cycle arrest in AML cells, and can be u...		Apoptosis , Epigenetic Reader Domain
T3465	Vesnarinone	OPC-8212,Arkin,Piteranometozine	HIV Protease , PDE
	Vesnarinone (Arkin) (INN) is a mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest, dose-dependent, positive inotropic activity, but minimal negative chronotropic activity. It also suppresses cel...		HIV Protease , PDE
T11961	MBM-55S		GSK-3 , MAPK , Akt , Bcr-Abl , CDK , S6 Kinase , Aurora Kinase
	MBM-55S is an effective inhibitor of Nek2 with an IC50 of 1 nM. MBM-55S indecus cell cycle arrest and apoptosis thereby inhibiting the proliferation of cancer cells. MBM-55S shows antitumor activities.
T22646	CFM 4	CFM-4,CFM4	Apoptosis , APC
	CFM 4 is a potent small molecule CARP-1/APC-2 antagonist that prevents CARP-1 from binding to APC-2, contributes to G2M cell cycle arrest, and induces apoptosis, with an IC50 in the range of 10-15 μM.CFM 4 inhibits the g...		Apoptosis , APC
T12040	Milademetan	RAIN-32,DS-3032,DS3032b	Mdm2 , Others
	Milademetan (DS-3032) is an orally active and potent MDM2 inhibitor with antitumor activity that induces G1 cell cycle arrest, senescence, and apoptosis.Milademetan is used in the study of acute myeloid leukemia and soli...		Mdm2 , Others
T10760	Ceramides Mixture		Telomerase
	Ceramides Mixture, an endogenous ceramide, consists of hydroxy and non-hydroxy fatty acid-containing ceramides. It is involved in the regulation of cell cycle arrest, growth inhibition, and modulation of telomerase activ...		Telomerase
T9703	GSK778		Epigenetic Reader Domain
	GSK778 is a potent and selective inhibitor of BD1 bromodomain such as BRD2 BD1 (IC50s = 75 nM), BRD3 BD1 (IC50s = 41 nM), BRD4 BD1 (IC50s = 41 nM), and BRDT BD1 (IC50s = 143 nM). GSK778 inhibits proliferation, induces a ...		Epigenetic Reader Domain
T1272L	Cytarabine hydrochloride	Ara-C hydrochloride,Cytosine Arabinoside hydrochloride	DNA/RNA Synthesis
	Cytarabine hydrochloride (Ara-C hydrochloride) is a nucleoside analog that causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC 50 of 16 nM. Cytarabine hydrochloride ...		DNA/RNA Synthesis

Compounds

MBM-55

T11960

Synonym:

Target: GSK-3, MAPK, DYRK, Akt, Chk, Bcr-Abl, CDK, S6 Kinase, Aurora Kinase

9-ING-41

T14066

Synonym:

Target: Apoptosis, GSK-3, Autophagy

Pentamidine

T23133

Synonym:

Target: Phosphatase, Antibacterial, Antibiotic, Parasite, Antifungal

SC144

T6207

Synonym:

Target: Apoptosis, Interleukin

Target: Microtubule Associated

Target: Akt, PKA, S6 Kinase, Autophagy

Batabulin

T10460

Synonym: T138067

Target: Apoptosis, Microtubule Associated

Pentamidine isethionate

T1654

Synonym: Pentamidine isethionate salt,Pentamidine diisethionate

Target: Phosphatase, Antibacterial, Antibiotic, Parasite, Antifungal

KRCA-0008

T2641

Synonym: KRCA 0008,KRCA0008

Target: Apoptosis, Pim

OTS514 hydrochloride

T4134

Synonym: OTS-514 hydrochloride,OTS514 hydrochloride(1338540-63-8(free base))

Target: Apoptosis, TOPK

Pentamidine dihydrochloride

T23132

Synonym: MP-601205 dihydrochloride

Target: Phosphatase, Antibacterial, Antibiotic, Parasite, Antifungal

CCT128930 hydrochloride

T6303L

Synonym: CCT128930 hydrochloride(885499-61-6 Free base)

Target: Apoptosis, Akt, PKA, mTOR, Autophagy

Alisertib

T2241

Synonym: MLN 8237

Target: Apoptosis, Aurora Kinase, Autophagy

SKF-96365 hydrochloride

T2170

Synonym: SKF96365

Target: Apoptosis, Potassium Channel, Calcium Channel, TRP/TRPV Channel, Autophagy

OTS514

T4134L

Synonym: OTS514 HCl,OTS514 Hydrochloride,OTS-514,OTS 514

Target: Apoptosis, TOPK

AOH1160

T10343

Synonym: N-(2-Oxo-2-(2-phenoxyphenylamino)ethyl)-1-naphthamide

Target: Apoptosis, DNA/RNA Synthesis

Synonym: KPT-185,KPT 185

Target: CRM1

GGTI298 Trifluoroacetate

T6844

Synonym: GGTI 298,GGTI 298 TFA salt

Target: Apoptosis, Transferase, Ras

Flavopiridol hydrochloride

T2615

Synonym: Alvocidib Hydrochloride,NSC 649890,MDL 107826A,HL 275,FLAVOPIRIDOL HCL,NSC 649890 HCl

Target: HIV Protease, CDK, Autophagy

Synonym: CB-1348,Chloroambucil,WR-139013

Target: DNA Alkylator/Crosslinker, DNA Alkylation

TZ9

T17187

Synonym:

Target: Apoptosis, E1/E2/E3 Enzyme

4-Oxofenretinide

T4189

Synonym: 3-Keto fenretinide

Target: cell cycle arrest

Probimane

T3485

Synonym: AT-2153,MM-159

Target: Apoptosis, PI3K

Triciribine phosphate

T19699

Synonym: TCN-P,VD 002,VQD-002

Target: Apoptosis, Akt

Tubulin polymerization-IN-43

T77647

Synonym:

Target: Apoptosis, Microtubule Associated

Sandacanol

T36898

Synonym: Sandranol,2-Ethyl-4-(2,2,3-trimethylcyclopent-3-en-yl)-but-2-en-1-ol

Target: Apoptosis

Sodium Oxamate

T19831

Synonym: oxamate sodium,Oxamic acid sodium salt,Aminooxoacetic acid sodium salt,SO

Target: Apoptosis, Dehydrogenase, CDK

MC2590

T73515

Synonym:

Target: Apoptosis, HDAC

10058-F4

T3048

Synonym: c-Myc Inhibitor

Target: c-Myc, Autophagy

KPT330,(E)-

T1844

Synonym: (E)-RN,KPT-330,KPT330,KPT 330

Target: Gamma-secretase

Synonym: XX65023,XX 650 23

Target: Apoptosis, Epigenetic Reader Domain

Vesnarinone

T3465

Synonym: OPC-8212,Arkin,Piteranometozine

Target: HIV Protease, PDE

MBM-55S

T11961

Synonym:

Target: GSK-3, MAPK, Akt, Bcr-Abl, CDK, S6 Kinase, Aurora Kinase

CFM 4

T22646

Synonym: CFM-4,CFM4

Target: Apoptosis, APC

Milademetan

T12040

Synonym: RAIN-32,DS-3032,DS3032b

Target: Epigenetic Reader Domain

Cytarabine hydrochloride

T1272L

Synonym: Ara-C hydrochloride,Cytosine Arabinoside hydrochloride

Target: DNA/RNA Synthesis

Cat No.	Product Name	Synonyms	Targets
TN1019	Beta-mangostin	β-Mangostin	Apoptosis , Antibacterial , Parasite
	Beta-mangostin (β-Mangostin) is a xanthone compound with antibacterial and antimalarial activities. Beta-mangostin present in Cratoxylum arborescens and exhibits antimycobacterial activity against Mycobacterium tuberculo...		Apoptosis , Antibacterial , Parasite
T2764	(S)-10-Hydroxycamptothecin	10-Hydroxycamptothecin,10-HCPT	Apoptosis , Topoisomerase
	(S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor, utilized as a clinical therapy agent against hepatoma.		Apoptosis , Topoisomerase
T3909	Pulsatilla saponin D	Hederacolchiside A,SB365	Apoptosis , Others
	Pulsatilla saponin D (Hederacolchiside A) has exhibited potential beneficial effects as a chemopreventive agent for critical health conditions including cancer, and it inhibits cell growth via cell cycle arrest and apopt...		Apoptosis , Others
T6S2038	Ziyuglycoside II		Apoptosis , Antioxidant , Reactive Oxygen Species
	1. Ziyuglycoside II has anti-inflammation and antioxidation properties. 2. Ziyuglycoside II has antibiosis, and homeostasis properties. 3. Ziyuglycoside II has anticancer, and antitumor properties against gastric cancer ...		Apoptosis , Antioxidant , Reactive Oxygen Species
T2336	Vitamin K2	Menatetrenone	Endogenous Metabolite
	Vitamin K2 (Menatetrenone) is a menaquinone compound and form of vitamin K2 with potential antineoplastic activity. Menatetrenone may act by modulating the signaling of certain tyrosine kinases, thereby affecting several...		Endogenous Metabolite
T1508	Decitabine	Dacogen,NSC 127716,Deoxycytidine,5-Aza-2'-deoxycytidine	Apoptosis , Nucleoside Antimetabolite/Analog , DNA Methyltransferase
	Decitabine (Deoxycytidine) is a deoxycytidine analog, a DNA methyltransferase inhibitor with oral activity. Decitabine has antitumor activity and antimetabolic activity. Decitabine induces cell cycle arrest and apoptosis...
T3774	Gracillin		cell cycle arrest
	Gracillin can induce cell cycle arrest, oxidative stress, and apoptosis in HL60 cells, and has the potential to be developed as an antitumor agent. Gracillin can be selected as lead compounds for the development of new d...		cell cycle arrest
T6S0234	Toosendanin		Others
	1. Toosendanin possesses hepatotoxicity. 2. Toosendanin has effects on the growth, cell cycle arrest, induction of apoptosis and the involved signaling pathway in human promyelocytic leukemia HL-6 cells. 3. Toosendanin i...		Others
TN1244	3'-Demethylnobiletin		LDL , NF-κB , Integrin , Lipoxygenase , DNA/RNA Synthesis
	3'-Demethylnobiletin has chemopreventive effects on colon carcinogenesis, it can significantly inhibit the growth of human colon cancer cells, cause cell-cycle arrest, induce apoptosis, and profoundly modulate signaling ...		LDL , NF-κB , Integrin , Lipoxygenase , DNA/RNA Synthesis
T2S0820	Karanjin		Apoptosis , AMPK
	Karanjin is a flavonoid obtained from the seeds of the karanja tree.Karanjin induces GLUT4 translocation in skeletal muscle cells by increasing AMPK activity. Karanjin can induce cancer cell death through cell cycle arre...		Apoptosis , AMPK
T2S0886	Terrestrosin D		Apoptosis , Others
	Terrestrosin D can induce apoptotic cell death and inhibit angiogenesis in xenograft tumor cells, cell cycle arrest and induction of apoptosis in cancer cells and endothelial cells might be plausible mechanisms of action...		Apoptosis , Others
T1272	Cytarabine	Ara-C,Cytosine Arabinoside,Cytosine β-D-arabinofuranoside,Arabinocytidine	Apoptosis , Nucleoside Antimetabolite/Analog , DNA/RNA Synthesis , Endogenous Metabolite , Autophagy , HSV
	Cytarabine (Ara-C) is a nucleoside analog, an inhibitor of DNA synthesis (IC50=16 nM). Cytarabine inhibits DNA polymerase and induces cell cycle arrest, autophagy, and apoptosis. Cytarabine has antitumor activity.
TN1658	Ganoderenic acid D		Apoptosis , Others
	Ganoderenic acid D is a natural product isolated from the effective compounds of Ganoderma lucidum extract (GLE). Ganoderenic acid D induces cell cycle arrest and apoptosis and inhibits the proliferation of cancer cells.		Apoptosis , Others
T4S1540	Myrislignan		Apoptosis , NF-κB
	Myrislignan has anti-inflammatory, and anti-cancer activities, it inhibited NF-κB signalling pathway activation, inhibited the proliferation of A549 cells in a dose- and time-dependent manner, it also significantly induc...		Apoptosis , NF-κB
T3008	Lawsone methyl ether	2-Methoxy-1,4-naphthoquinone,2-Methoxy-p-naphthoquinone,2-Methoxynaphthoquinone	Apoptosis , Antibacterial , Antifungal
	Lawsone methyl ether (2-Methoxy-1,4-naphthoquinone) induced apoptosis of A549 cells independent of cell cycle arrest, and is mediated by the JNK and p38 MAPK signaling pathways. Further analysis demonstrated that these s...		Apoptosis , Antibacterial , Antifungal
TN1620	Eriocalyxin B		Apoptosis , cAMP , NF-κB , STAT
	Eriocalyxin B induces apoptosis and cell cycle arrest in pancreatic adenocarcinoma cells through caspase- and p53-dependent pathways, should be considered a candidate for pancreatic cancer treatment; it is a specific inh...		Apoptosis , cAMP , NF-κB , STAT
TN1222	26-Deoxyactein	27-Deoxyactein,23-epi-26-Deoxyactein	NOS , CDK , NO Synthase
	23-epi-26-Deoxyactein (27-Deoxyactein) has anti-inflammatory activity, it inhibits nitric oxide production by reducing iNOS expression without affecting activity of the enzyme. It also has anti-cancer activity, it can in...		NOS , CDK , NO Synthase
T2220	2-Methoxyestradiol	NSC-659853,2-MeOE2,2-ME2	Apoptosis , Reactive Oxygen Species , Microtubule Associated , Endogenous Metabolite , HIF , Autophagy
	2-Methoxyestradiol (2-ME2) is an orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-Methoxyestradiol inhibits angiogenesis by reducing endothelial cell proliferation and inducing endotheli...
T5S0527	Rhodojaponin III		Others
	1. Rhodojaponin III has antifeedant and oviposition deterrence effects against many kinds of insects, BdorCSP2 of B. dorsalis could be involved in chemoreception of Rhodojaponin III and played a critical role. 2. Rhodoja...		Others
T3386	Kaempferitrin	Lespedin,Kaempferol,Lespenephryl,Lespenefril,Kaempferol 3,7-dirhamnoside	cell cycle arrest , Glucokinase , IGF-1R
	Kaempferitrin (Lespenephryl) has antidepressant-like effect related to the serotonergic system, principally 5-HT1A. Kaempferitrin exerts cytotoxic and antitumor effects against HeLa cells. Kaempferitrin stimulates glucos...		cell cycle arrest , Glucokinase , IGF-1R
TN1804	Isosilybin A		Apoptosis , Tyrosinase , PPAR , ABC
	Isosilybin A is a partial PPARγ agonist, it significantly induced ABCA1 protein expression, it inhibited both monophenolase (IC50=1.7-7.6μM) and diphenolase (IC50=12.1-44.9μM) of tyrosinase. Isosilybin A shows anti-angio...		Apoptosis , Tyrosinase , PPAR , ABC
T4S1615	Sanggenon C	Sanggenone C	NF-κB
	1. Sanggenon C (Sanggenone C) inhibits tumor cellular proteasomal activity and cell viability, via induction of cell cycle arrest and cell death , inhibiting the proteasome function. 2. Sanggenon C and O inhibited NO pro...		NF-κB
T3426	Bacoside A		MMP , Others , TNF , Dopamine Receptor , NOS , ROS
	Bacoside A has a possible anticancer activity that could be inducing cell cycle arrest and apoptosis through Notch pathway in GBM in vitro. It exerts cytoprotective efficacy by attenuation of ROS generated through oxidat...		MMP , Others , TNF , Dopamine Receptor , NOS , ROS
T3S0081	Oxypeucedanin	(+-)-Oxypeucedanin,Oxypeucadanin	Potassium Channel
	1. Oxypeucedanin ((+-)-Oxypeucedanin) has novel anticancer effect, mediated via induction of G2-M cell cycle arrest and apoptosis in human prostate carcinoma DU145 cells. 2. Oxypeucedanin is a kind of open-channel blocke...		Potassium Channel
T6S1917	Schisandrol B	Gomisin A,TJN-101,Besigomsin,Gamma-Schisandrin,Schizandrol B,Wuweizi alcohol-B	P450 , Reactive Oxygen Species , Autophagy
	1. Schisandrol B (Besigomsin) may exert neuroprotective effects by attenuating the microglia-mediated neuroinflammatory response via inhibiting the TLR4-mediated NF-κB and MAPKs signaling pathways. 2. Schisandrol B has a...		P450 , Reactive Oxygen Species , Autophagy
T2S2215	Crebanine		Apoptosis , Others , Akt
	1. Crebanine iv 5mg/kg can eonvert BaCl_2-induced arrhythmia into sinus rhythm in rats, and can significantly increase the tolerant dose of aconitine to produce ventrieular fibrillation(VF) and cardiac arrest (CA) in rat...		Apoptosis , Others , Akt
T6S1315	Oroxylin A	6-Methoxybaicalein,Baicalein 6-methyl ether	Virus Protease , HIF/HIF Prolyl-Hydroxylase , Autophagy
	1. Oroxylin A (Baicalein 6-methyl ether) has various anti-tumor effects including apoptosis, cell cycle arrest, drug-resistant reversion. 2. Oroxylin A possesses abilities of inhibiting the ATRA-induced IL-6 production v...		Virus Protease , HIF/HIF Prolyl-Hydroxylase , Autophagy
T37067	9-hydroxy Stearic Acid		HDAC
	9-hydroxy Stearic Acid is a hydroxy fatty acid that is the active metabolite of 9-PAHSA. 9-hydroxy Stearic Acid is formed from 9-PAHSA through carboxyl ester lipase in the liver and pancreas. The 9-hydroxy Stearic Acid (...		HDAC
T3824	Jaceosidin		Apoptosis , BCL , COX , UGT
	Jaceosidin has anti-oxidative activity. Jaceosidin has anti-inflammatory activity, also a microglial inhibitor with anti-neuroinflammation activity. aceosidin has anticancer activity, modulates the ERK/ATM/Chk1/2 pathway...		Apoptosis , BCL , COX , UGT
TN1141	Isodeoxyelephantopin		NF-κB , Reactive Oxygen Species , Autophagy
	Isodeoxyelephantopin exerts antitumor effects on several cancer cells by inducing apoptosis , cell cycle arrest , and inhibiting proliferation. It enhances apoptosis and inhibit invasion and osteoclastogenesis by inhibit...		NF-κB , Reactive Oxygen Species , Autophagy
TN5371	8-Hydroxy-ar-turmerone
	8-Hydroxy-ar-turmerone may exhibit antitumor activity against breast cancer cells via cell death and cell cycle arrest.
TN6511	Tessaric acid
	Tessaric acid has antifeedant and allelochemical effects. Tessaric acid derivatives induce G/M cell cycle arrest in human solid tumor cell lines.
TN6547	Angustifoline
	Angustifoline has activity against gram-positive bacteria. It inhibits human colon cancer cell growth by inducing autophagy along with mitochondrial-mediated apoptosis, suppression of cell invasion and migration and stim...
T27711	Kahweol Eicosanate	J002075,J 002075,J-002075
	Kahweol Eicosanate is a semi-syntetic derivative of kahweol. Kahweol Eicosanate exhibits a wide variety of biological activities, including inducing cell cycle arrest and apoptosis in oral squamous cell carcinoma cells, ...
TN4132	Germanicol
	Germanicol induces selective growth inhibitory effects in human colon HCT-116 and HT29 cancer cells through induction of apoptosis, cell cycle arrest and inhibition of cell migration. Germanicol may have anti-inflammator...
TN1728	Hellebrigenin		PARP , Akt , CDK
	Hellebrigenin has anti-hepatoma activities, it induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells through inhibition of Akt. Hellebrigenin exhibites moderate to strong activity against ...		PARP , Akt , CDK
TN6591	Cannabisin B
	Cannabisin B possesses considerable antiproliferative activity and that it may be utilised as a promising chemopreventive agent against hepatoblastoma disease. It induces autophagic cell death by inhibiting the AKT/mTOR ...
T3930	Taraxerol acetate	Taraxeryl acetate	Phosphatase , HSV
	Taraxeryl acetate shows the significant antiviral activity against herpes simplex virus (type II). It has less effect on cell cycle arrest and apoptosis of AGS cells than taraxerol. A. roxburghiana has antidiabetic activ...		Phosphatase , HSV
TN1617	Ergosta-4,6,8(14),22-tetraen-3-one		BCL , Caspase , p53
	Ergosta-4,6,8(14),22-tetraen-3-one has cytotoxic activity against human gastric cancer cell, it can induce G2/M cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells, these results would be useful...		BCL , Caspase , p53
T78479	Manool
	Manool, a diterpene derived from Salvia officinalis, demonstrates selective cytotoxicity in cancer cells and causes cell cycle arrest at the G(2)/M phase [1] [2].
T70495	Scytonemin
	Scytonemin is a biological pigment synthesized by many strains of cyanobacteria, including Calothrix sp., Lyngbya aestuarii, and others. Scytonemin is also a potent PKL1 inhibitor, which inhibits cell proliferation and a...
T75569	Xerophilusin B
	Xerophilusin B, isolated from Isodon xerophilus as an anticancer agent, demonstrates antiproliferative effects on esophageal squamous cell carcinoma (ESCC) cell lines. It induces G2/M cell cycle arrest and mediates apopt...
T75698	Xylopine
	Xylopine, an aporphine alkaloid, exhibits cytotoxic effects on cancer cells by inducing oxidative stress, provoking G2/M cell cycle arrest, and triggering apoptosis [1].
T75669	Odoroside A
	Odoroside A, extracted from the leaves of Nerium oleander Linn., exhibits anti-cancer properties by inducing apoptosis and cell cycle arrest via the ROS/p53 signaling pathway, resulting in tumor cell death [1].
T73681	Aspidin BB
	Aspidin BB, a phloroglucinol derivative isolated from the aerial part of Dryopteris championii, exhibits anticancer activity. It induces cell cycle arrest and apoptosis in human ovarian HO-8910 cells [1] [2].
TN4263	Isoangustone A		MMP , GSK-3 , NF-κB , ROS , Akt , PI3K , CDK , JNK
	Isoangustone A has antitumor activity, it can induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells, it inhibits cell proliferation by targeting PI3K, MKK4, and MKK7 in human melanoma. Isoang...		MMP , GSK-3 , NF-κB , ROS , Akt , PI3K , CDK , JNK
TN5264	Xanthoxyletin		TNF , NOS , ROS , COX , Antifection
	Xanthoxyletin shows potent antibacterial, fungicidal, and algicidal properties, it also has anticancer, and anti-inflammatory activities. It shows an inhibitory effect on iNOS protein expression at 10 microM, it also can...		TNF , NOS , ROS , COX , Antifection
T75622	β-Apopicropodophyllin
	β-Apopicropodophyllin, a natural product isolated from Hyptis wticillata, promotes apoptosis through mechanisms including microtubule disruption, DNA damage, cell cycle arrest, and ER stress. This compound holds potentia...
TN4168	Grifolin		Others
	Grifolin has anti-cancer effects, it induces apoptosis and promotes cell cycle arrest in the A2780 human ovarian cancer cell line via inactivation of the ERK1/2 and Akt pathways; it enhances the differentiation and proli...		Others
TN2344	Swainsonine	Tridolgosir	Apoptosis , Others , Antibiotic
	Swainsonine (Tridolgosir) is an alkaloid isolated from Astragalus membranaceus and is a potent and reversible inhibitor of alpha-mannosidase. swainsonine has antitumour activity and induces apoptosis and cell cycle arres...		Apoptosis , Others , Antibiotic
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Natural Products

Beta-mangostin

TN1019

Synonym: β-Mangostin

Target: Apoptosis, Antibacterial, Parasite

(S)-10-Hydroxycamptothecin

T2764

Synonym: 10-Hydroxycamptothecin,10-HCPT

Target: Apoptosis, Topoisomerase

Pulsatilla saponin D

T3909

Synonym: Hederacolchiside A,SB365

Target: Apoptosis, Others

Ziyuglycoside II

T6S2038

Synonym:

Target: Apoptosis, Antioxidant, Reactive Oxygen Species

Vitamin K2

T2336

Synonym: Menatetrenone

Target: Endogenous Metabolite

Decitabine

T1508

Synonym: Dacogen,NSC 127716,Deoxycytidine,5-Aza-2'-deoxycytidine

Target: Apoptosis, Nucleoside Antimetabolite/Analog, DNA Methyltransferase

Gracillin

T3774

Synonym:

Target: cell cycle arrest

Target: LDL, NF-κB, Integrin, Lipoxygenase, DNA/RNA Synthesis

Karanjin

T2S0820

Synonym:

Target: Apoptosis, AMPK

Terrestrosin D

T2S0886

Synonym:

Target: Apoptosis, Others

Cytarabine

T1272

Synonym: Ara-C,Cytosine Arabinoside,Cytosine β-D-arabinofuranoside,Arabinocytidine

Target: Apoptosis, Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis, Endogenous Metabolite, Autophagy, HSV

Ganoderenic acid D

TN1658

Synonym:

Target: Apoptosis, Others

Myrislignan

T4S1540

Synonym:

Target: Apoptosis, NF-κB

Lawsone methyl ether

T3008

Synonym: 2-Methoxy-1,4-naphthoquinone,2-Methoxy-p-naphthoquinone,2-Methoxynaphthoquinone

Target: Apoptosis, Antibacterial, Antifungal

Eriocalyxin B

TN1620

Synonym:

Target: Apoptosis, cAMP, NF-κB, STAT

26-Deoxyactein

TN1222

Synonym: 27-Deoxyactein,23-epi-26-Deoxyactein

Target: NOS, CDK, NO Synthase

2-Methoxyestradiol

T2220

Synonym: NSC-659853,2-MeOE2,2-ME2

Target: Apoptosis, Reactive Oxygen Species, Microtubule Associated, Endogenous Metabolite, HIF, Autophagy

Synonym: Lespedin,Kaempferol,Lespenephryl,Lespenefril,Kaempferol 3,7-dirhamnoside

Target: cell cycle arrest, Glucokinase, IGF-1R

Isosilybin A

TN1804

Synonym:

Target: Apoptosis, Tyrosinase, PPAR, ABC

Sanggenon C

T4S1615

Synonym: Sanggenone C

Target: MMP, Others, TNF, Dopamine Receptor, NOS, ROS

Oxypeucedanin

T3S0081

Synonym: (+-)-Oxypeucedanin,Oxypeucadanin

Target: Potassium Channel

Schisandrol B

T6S1917

Synonym: Gomisin A,TJN-101,Besigomsin,Gamma-Schisandrin,Schizandrol B,Wuweizi alcohol-B

Target: P450, Reactive Oxygen Species, Autophagy

Crebanine

T2S2215

Synonym:

Target: Apoptosis, Others, Akt

Oroxylin A

T6S1315

Synonym: 6-Methoxybaicalein,Baicalein 6-methyl ether

Target: Virus Protease, HIF/HIF Prolyl-Hydroxylase, Autophagy

9-hydroxy Stearic Acid

Target: Apoptosis, BCL, COX, UGT

Isodeoxyelephantopin

TN1141

Synonym:

Target: NF-κB, Reactive Oxygen Species, Autophagy

8-Hydroxy-ar-turmerone

Synonym: J002075,J 002075,J-002075

Target: PARP, Akt, CDK

Synonym: Taraxeryl acetate

Target: Phosphatase, HSV

Ergosta-4,6,8(14),22-tetraen-3-one

TN1617

Synonym:

Target: BCL, Caspase, p53

Target: MMP, GSK-3, NF-κB, ROS, Akt, PI3K, CDK, JNK

Xanthoxyletin

TN5264

Synonym:

Target: TNF, NOS, ROS, COX, Antifection

β-Apopicropodophyllin

Target: Apoptosis, Others, Antibiotic

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Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPH-01658	MAGEA4 Protein, Human, Recombinant (His)	Human	HEK293
	Regulates cell proliferation through the inhibition of cell cycle arrest at the G1 phase. Also negatively regulates p53-mediated apoptosis.
TMPH-02234	TMPRSS11A Protein, Human, Recombinant (His)	Human	E. coli
	Probable serine protease which may play a role in cellular senescence. Overexpression inhibits cell growth and induce G1 cell cycle arrest.
TMPH-01659	MAGEA4 Protein, Human, Recombinant (A173T, His & Myc)	Human	E. coli
	Regulates cell proliferation through the inhibition of cell cycle arrest at the G1 phase. Also negatively regulates p53-mediated apoptosis.
TMPH-00605	CDTB Protein, E. coli, Recombinant (His & Myc & SUMO)	E. coli	E. coli
	Part of the tripartite complex that is required for the CDT activity. CdtB exhibits a DNA-nicking endonuclease activity, and very probably causes DNA damage in intoxicated cells. This damage induces G2/M cell cycle arres...
TMPH-01520	HIV-1 (group M, subtype K, isolate 96CM-MP535) Protein Vpr (His & Myc)	HIV-1	E. coli
	During virus replication, may deplete host UNG protein, and incude G2-M cell cycle arrest. Acts by targeting specific host proteins for degradation by the 26S proteasome, through association with the cellular CUL4A-DDB1 ...
TMPH-01519	HIV-1 (group M, subtype C, isolate 92BR025) Protein Vpr (His & Myc)	HIV-1	E. coli
	During virus replication, may deplete host UNG protein, and incude G2-M cell cycle arrest. Acts by targeting specific host proteins for degradation by the 26S proteasome, through association with the cellular CUL4A-DDB1 ...
TMPH-03415	Rift valley fever virus (RVFV) (strain ZH-548 M12) Non-structural protein S (His & Myc)	RVFV	E. coli
	Plays a role in the escape of host innate immune response by promoting the degradation of host EIF2AK2/PKR and inhibiting host transcription. Cytoplasmic NSs interacts with host FBXW11 to degrade PKR whereas nuclear pool...
TMPY-04368	Chk1 Protein, Human, Recombinant (GST)	Human	Baculovirus-Insect Cells
	CHK1 / CHEK1 contains 1 protein kinase domain and belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, NIM1 subfamily. It is a member of checkpoint kinases (Chks). Chks Checkpoint kinases (Chks)...
TMPY-04433	Chk1 Protein, Mouse, Recombinant (His & GST)	Mouse	Baculovirus-Insect Cells
	CHK1 / CHEK1 contains 1 protein kinase domain and belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, NIM1 subfamily. It is a member of checkpoint kinases (Chks). Chks Checkpoint kinases (Chks)...
TMPJ-01097	ZBTB17 Protein, Human, Recombinant (His)	Human	E. coli
	Zinc Finger and BTB Domain-Containing Protein 17 (ZBTB17) belongs to the Kruppel C2H2-type zinc finger protein family. ZBTB17 may function as a housekeeping DNA-binding protein that regulates the expression of specific g...
TMPH-01849	Human parvovirus B19 (isolate AU) Non-capsid protein NS-1 (His & SUMO)	HPV B19	E. coli
	Multifunctional protein essential for viral DNA replication, which cooperatively interacts with the viral DNA origin of replication and transactivates several promoters including the viral p6 promoter. Binds the origin o...
TMPH-01826	Human Papilloma Virus type 11 (HPV 11) Protein E4 (His)	HPV 11	E. coli
	Contributes to multiple aspects of the viral life cycle including viral genome amplification, suppression of suprabasal cell differentiation and egress of newly formed virions. Induces host cell cycle arrest at the G2 ph...
TMPH-01831	Human Papilloma Virus type 16 (HPV 16) Protein E4 (His & Myc)	HPV 16	E. coli
	Contributes to multiple aspects of the viral life cycle including viral genome amplification, suppression of suprabasal cell differentiation and egress of newly formed virions. Induces host cell cycle arrest at the G2 ph...
TMPY-01561	PIG3 Protein, Human, Recombinant (His)	Human	E. coli
	Nutlin-3 variably induces apoptosis and cell cycle arrest in cancer cells while it shows low/absent cytotoxicity in normal cells, Nutlin-3 is a promising anti-cancer agent, which exhibits activity against a variety of ca...
TMPH-01839	Human Papilloma Virus type 6a (HPV 6a) Protein E4 (His & Myc)	HPV 6a	E. coli
	Contributes to multiple aspects of the viral life cycle including viral genome amplification, suppression of suprabasal cell differentiation and egress of newly formed virions. Induces host cell cycle arrest at the G2 ph...
TMPY-04681	CHEK2 Protein, Human, Recombinant (GST)	Human	Baculovirus-Insect Cells
	In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by CHEK2 gene is a cell cycle checkpoint regulator and putativ...
TMPY-03655	GADD45G Protein, Human, Recombinant	Human	E. coli
	GADD45G, also known as CR6, is part of the nuclear proteins to interact with various proteins whose transcript levels are raised after stressful growth arrest conditions and treatment with DNA-damaging agents. GADD45G re...
TMPY-04435	CHEK2 Protein, Mouse, Recombinant (His & GST)	Mouse	Baculovirus-Insect Cells
	In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by CHEK2 gene is a cell cycle checkpoint regulator and putativ...
TMPY-03048	PRAP1 Protein, Human, Recombinant (mFc)	Human	HEK293
	PRAP1 is a protein interacting partner of MAD1 and that PRAP1 is able to down-regulate MAD1 and suppress mitotic checkpoint signalling in HCC. PRAP1 is a novel p53 target gene. The induction of PRAP1 expression by p53 ma...
TMPY-03076	PRAP1 Protein, Human, Recombinant (His)	Human	HEK293
	PRAP1 is a protein interacting partner of MAD1 and that PRAP1 is able to down-regulate MAD1 and suppress mitotic checkpoint signalling in HCC. PRAP1 is a novel p53 target gene. The induction of PRAP1 expression by p53 ma...
TMPH-02200	TXNIP Protein, Human, Recombinant (B2M & His)	Human	in vitro E. coli expression system
	May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated ...
TMPH-02929	TXNIP Protein, Mouse, Recombinant (His)	Mouse	Yeast
	May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated ...
TMPH-01781	NSMCE3 Protein, Human, Recombinant (His)	Human	E. coli
	Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohe...
TMPH-03264	P53 Protein, Rat, Recombinant (His)	Rat	E. coli
	Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negativel...
TMPH-02574	P53 Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negativel...
TMPH-00900	Human adenovirus C serotype 5 Early E1A protein (His & SUMO)	HAdV-5	E. coli
	Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery t...
TMPH-03506	IpaB Protein, Shigella flexneri, Recombinant (His)	Shigella flexneri	E. coli
	Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. Forms a pore with IpaC, which is inserted into the host cell membrane through the Mxi/Spa apparatus, during cell co...
TMPH-03165	Beta-lactamase Protein, Pseudomonas aeruginosa, Recombinant (His & SUMO)	Pseudomonas aeruginosa	E. coli

TMPH-02132	Spindlin-1 Protein, Human, Recombinant (GST)	Human	E. coli
	Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway downstr...
TMPY-00998	S100A2 Protein, Human, Recombinant	Human	E. coli
	The calcium-binding protein S100A2 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 family genes are located as a cluster on chromosome 1q21, and S100 proteins consisting of at...
TMPY-00910	S100A2 Protein, Human, Recombinant (hFc)	Human	HEK293
	The calcium-binding protein S100A2 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 family genes are located as a cluster on chromosome 1q21, and S100 proteins consisting of at...
TMPH-01075	P53 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negativel...
TMPH-02160	SMARCB1 Protein, Human, Recombinant (His)	Human	E. coli
	Core component of the BAF (hSWI/SNF) complex. This ATP-dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor form...
TMPH-01328	FBXL2 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target...
TMPJ-00948	Endostatin Protein, Mouse, Recombinant (His)	Mouse	Human Cells
	Endostatin, an endogenous non‑glycosylated inhibitor of endothelial cell proliferation and angiogenesis. It is produced and/or trimmed by metalloproteinases such as MMP‑2 and MMP‑9, and cathepsins S, B and L. The N‑termi...
TMPY-04267	MSH2 Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	MSH2 is a key DNA mismatch repair protein, which plays an important role in genomic stability. In addition to its DNA repair function, MSH2 serves as a sensor for DNA base analogs-provoked DNA replication errors and bind...
TMPY-04392	RSK3 Protein, Human, Recombinant (GST)	Human	Baculovirus-Insect Cells
	Ribosomal protein S6 kinase alpha-2, also known as 9 kDa ribosomal protein S6 kinase 2, MAP kinase-activated protein kinase 1c, MAPK-activated protein kinase 1c, Ribosomal S6 kinase 3, RSK-3, RPS6KA2 and MAPKAPK1C, is a ...
TMPH-02630	MDM2 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional ...
TMPY-02228	P53 Protein, Cynomolgus, Recombinant	Cynomolgus	E. coli
	p53, also known as Tp53, is a DNA-binding protein which belongs to the p53 family. It contains transcription activation, DNA-binding, and oligomerization domains. p53 protein is expressed at low level in normal cells and...
TMPH-01552	IRF1 Protein, Human, Recombinant (GST & His)	Human	Baculovirus
	Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. Regulates transcription of IFN and IFN-inducible genes, host response to viral and bacterial infections,...

MAGEA4 Protein, Human, Recombinant (His)

TMPH-01658

Species: Human

Expression System: HEK293

TMPRSS11A Protein, Human, Recombinant (His)

TMPH-02234

Species: Human

Expression System: E. coli

MAGEA4 Protein, Human, Recombinant (A173T, His & Myc)

TMPH-01659

Species: Human

Expression System: E. coli

CDTB Protein, E. coli, Recombinant (His & Myc & SUMO)

TMPH-00605

Species: E. coli

Expression System: E. coli

HIV-1 (group M, subtype K, isolate 96CM-MP535) Protein Vpr (His & Myc)

TMPH-01520

Species: HIV-1

Expression System: E. coli

HIV-1 (group M, subtype C, isolate 92BR025) Protein Vpr (His & Myc)

TMPH-01519

Species: HIV-1

Expression System: E. coli

Rift valley fever virus (RVFV) (strain ZH-548 M12) Non-structural protein S (His & Myc)

TMPH-03415

Species: RVFV

Expression System: E. coli

Chk1 Protein, Human, Recombinant (GST)

TMPY-04368

Species: Human

Expression System: Baculovirus-Insect Cells

Chk1 Protein, Mouse, Recombinant (His & GST)

TMPY-04433

Species: Mouse

Expression System: Baculovirus-Insect Cells

ZBTB17 Protein, Human, Recombinant (His)

TMPJ-01097

Species: Human

Expression System: E. coli

Human parvovirus B19 (isolate AU) Non-capsid protein NS-1 (His & SUMO)

TMPH-01849

Species: HPV B19

Expression System: E. coli

Human Papilloma Virus type 11 (HPV 11) Protein E4 (His)

TMPH-01826

Species: HPV 11

Expression System: E. coli

Human Papilloma Virus type 16 (HPV 16) Protein E4 (His & Myc)

TMPH-01831

Species: HPV 16

Expression System: E. coli

PIG3 Protein, Human, Recombinant (His)

TMPY-01561

Species: Human

Expression System: E. coli

Human Papilloma Virus type 6a (HPV 6a) Protein E4 (His & Myc)

TMPH-01839

Species: HPV 6a

Expression System: E. coli

CHEK2 Protein, Human, Recombinant (GST)

TMPY-04681

Species: Human

Expression System: Baculovirus-Insect Cells

GADD45G Protein, Human, Recombinant

TMPY-03655

Species: Human

Expression System: E. coli

CHEK2 Protein, Mouse, Recombinant (His & GST)

TMPY-04435

Species: Mouse

Expression System: Baculovirus-Insect Cells

PRAP1 Protein, Human, Recombinant (mFc)

TMPY-03048

Species: Human

Expression System: HEK293

PRAP1 Protein, Human, Recombinant (His)

TMPY-03076

Species: Human

Expression System: HEK293

TXNIP Protein, Human, Recombinant (B2M & His)

TMPH-02200

Species: Human

Expression System: in vitro E. coli expression system

TXNIP Protein, Mouse, Recombinant (His)

TMPH-02929

Species: Mouse

Expression System: Yeast

NSMCE3 Protein, Human, Recombinant (His)

TMPH-01781

Species: Human

Expression System: E. coli

p53 Protein, Rat, Recombinant (His)

TMPH-03264

Species: Rat

Expression System: E. coli

p53 Protein, Mouse, Recombinant (His & SUMO)

TMPH-02574

Species: Mouse

Expression System: E. coli

Human adenovirus C serotype 5 Early E1A protein (His & SUMO)

TMPH-00900

Species: HAdV-5

Expression System: E. coli

IpaB Protein, Shigella flexneri, Recombinant (His)

TMPH-03506

Species: Shigella flexneri

Expression System: E. coli

Beta-lactamase Protein, Pseudomonas aeruginosa, Recombinant (His & SUMO)

TMPH-03165

Species: Pseudomonas aeruginosa

Expression System: E. coli

Spindlin-1 Protein, Human, Recombinant (GST)

TMPH-02132

Species: Human

Expression System: E. coli

S100A2 Protein, Human, Recombinant

TMPY-00998

Species: Human

Expression System: E. coli

S100A2 Protein, Human, Recombinant (hFc)

TMPY-00910

Species: Human

Expression System: HEK293

p53 Protein, Human, Recombinant (His & SUMO)

TMPH-01075

Species: Human

Expression System: E. coli

SMARCB1 Protein, Human, Recombinant (His)

TMPH-02160

Species: Human

Expression System: E. coli

FBXL2 Protein, Human, Recombinant (His & SUMO)

TMPH-01328

Species: Human

Expression System: E. coli

Endostatin Protein, Mouse, Recombinant (His)

TMPJ-00948

Species: Mouse

Expression System: Human Cells

MSH2 Protein, Human, Recombinant (His & GST)

TMPY-04267

Species: Human

Expression System: Baculovirus-Insect Cells

RSK3 Protein, Human, Recombinant (GST)

TMPY-04392

Species: Human

Expression System: Baculovirus-Insect Cells

MDM2 Protein, Mouse, Recombinant (His)

TMPH-02630

Species: Mouse

Expression System: E. coli

p53 Protein, Cynomolgus, Recombinant

TMPY-02228

Species: Cynomolgus

Expression System: E. coli

IRF1 Protein, Human, Recombinant (GST & His)

TMPH-01552

Species: Human

Expression System: Baculovirus

Cat No.	Product Name
L8100	Cell Cycle Compound Library		695 compounds
	A unique collection of 695 cell cycle related compounds for high throughput screening (HTS) and high content screening (HCS);

Libraries

Cell Cycle Compound Library

L8100

Compounds: 695