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Thrombin

Thrombin ( fibrinogenase, thrombase, thrombofort, topical, thrombin-C, tropostasin, activated blood-coagulation factor II, blood-coagulation factor IIa, factor IIa, E thrombin, beta-thrombin, gamma-thrombin) is a serine protease, an enzyme that, in humans, is encoded by the F2 gene. Prothrombin (coagulation factor II) is proteolytically cleaved to form thrombin in the clotting process. Thrombin in turn acts as a serine protease that converts soluble fibrinogen into insoluble strands of fibrin, as well as catalyzing many other coagulation-related reactions.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T15046 Dabigatran ethyl ester 429658-95-7 97.07%
Dabigatran ethyl ester
Dabigatran ethyl ester (Dabigatran (ethyl ester)) is an emerging oral anticoagulant and it also is a direct inhibitor of thrombin activity.
T16292 NFPS 405225-21-0 98%
NFPS
NFPS exerts neuroprotection via glyR alpha1 subunit in the rat model of transient focal cerebral ischaemia and reperfusion. NFPS is a selective and non-competiti...
T80097 Hirullin P18 131147-81-4 98%
Hirullin P18
Hirullin P18 is a potent thrombin inhibitor with anticoagulant properties [1].
T80115 Z-Gly-Pro-Arg-4MβNA 66647-41-4 98%
Z-Gly-Pro-Arg-4MβNA
Z-Gly-Pro-Arg-4MβNA is a thrombin substrate that, upon cleavage by thrombin, releases 4-methoxy-2-naphthylamine (4MβNA). This liberated 4MβNA reacts with 5-nitro...
T80119 Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) 131791-98-5 98%
Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated)
Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) is a hirugen-like peptide with greater thrombin affinity than Hirugen, exhibiting a dissociation constant (K ...
T80239 TFLLRNPNDK-NH2 145229-90-9 98%
TFLLRNPNDK-NH2
TFLLRNPNDK-NH2 is a biologically active peptide and a thrombin receptor activating peptide (TRAP). As a PAR-1 agonist, it reversibly binds to PAR-1, mimicking th...
T80512 Thrombin receptor peptide ligand 287964-20-9 98%
Thrombin receptor peptide ligand
Thrombin receptor peptide ligand, a thrombin receptor antagonist, serves as an antithrombotic agent [1].
T20654 Heparin 9005-49-6 98%
Heparin
Heparin (Adomiparin) is a mucopolysaccharide sulfate often used as an anticoagulant in clinical medicine.Heparin has shown partial anti-inflammatory activity in ...
T16377 Odiparcil 137215-12-4 98%
Odiparcil
Odiparcil is an orally active beta-d-thioxyloside analog. Odiparcil is an indirect thrombin inhibitor that exerts its anticoagulant effect through activation of ...
T12301 OM-189 55381-18-5 98%
OM-189
OM-189 is a selective inhibitor of synthetic thrombin.
T19580 Thrombin (MW 37kDa) 9002-04-4 98%
Thrombin (MW 37kDa)
Thrombin (MW 37kDa) is a trypsin-like allosteric serine protease.
T12782 RWJ-445167 226566-43-4 98%
RWJ-445167
RWJ-445167 is a thrombin and factor Xa dual inhibitor(Ki of 4.0 nM and 230 nM, respectively), with potent antithrombotic activity.
T10081 Thrombin inhibitor 1 855998-46-8 98%
Thrombin inhibitor 1
Thrombin inhibitor 1 is a potent inhibitor of thrombin (Ki: 0.66 nM, 2xaPTT=0.43 μM).
T6531 Heparin sodium salt 9041-08-1 BR
Heparin sodium salt
Heparin sodium is a sulfated polysaccharide, which belongs to the family of glycosaminoglycans. It is utilized as an anticoagulant and interacted with diverse pr...
T5133 Dabigatran Etexilate Mesylate 872728-81-9 99.94%
Dabigatran Etexilate Mesylate
Dabigatran Etexilate Mesylate (BIBR 1048MS) is the orally active prodrug of dabigatran. Dabigatran is a reversible and selective, direct thrombin inhibitor (DTI,...
T6825 Eltrombopag Olamine 496775-62-3 99.87%
Eltrombopag Olamine
Eltrombopag Olamine (Eltrombopag diethanolamine salt) is the orally active ethanolamine salt of eltrombopag, a small-molecule, nonpeptide thrombopoietin receptor...
T2368 Edoxaban Tosylate Monohydrate 1229194-11-9 99.86%
Edoxaban Tosylate Monohydrate
Edoxaban(DU-176) is an oral factor Xa (FXa) inhibitor in clinical development for stroke prevention.
T6625 Ozagrel hydrochloride 78712-43-3 99.78%
Ozagrel hydrochloride
Ozagrel hydrochloride (OKY-046 HCl) is a selective thromboxane A(2) synthetase inhibitor used for the improvement of postoperative cerebrovascular contraction an...
T0155 Argatroban 74863-84-6 99.77%
Argatroban
Argatroban (MCI-9038), a specific thrombin inhibitor, which is a non-heparin anticoagulant, prevents the formation of thrombi.
T3757 NQ301 130089-98-4 99.76%
NQ301
NQ301, an antithrombotic agent, inhibits collagen-challenged rabbit platelet aggregation (IC50: 10 mg/mL).
Dabigatran ethyl ester
T15046
Dabigatran ethyl ester (Dabigatran (ethyl ester)) is an emerging oral anticoagulant and it also is a direct inhibitor of thrombin activity.
NFPS
T16292
NFPS exerts neuroprotection via glyR alpha1 subunit in the rat model of transient focal cerebral ischaemia and reperfusion. NFPS is a selective and non-competiti...
Hirullin P18
T80097
Hirullin P18 is a potent thrombin inhibitor with anticoagulant properties [1].
Z-Gly-Pro-Arg-4MβNA
T80115
Z-Gly-Pro-Arg-4MβNA is a thrombin substrate that, upon cleavage by thrombin, releases 4-methoxy-2-naphthylamine (4MβNA). This liberated 4MβNA reacts with 5-nitro...
Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated)
T80119
Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) is a hirugen-like peptide with greater thrombin affinity than Hirugen, exhibiting a dissociation constant (K ...
TFLLRNPNDK-NH2
T80239
TFLLRNPNDK-NH2 is a biologically active peptide and a thrombin receptor activating peptide (TRAP). As a PAR-1 agonist, it reversibly binds to PAR-1, mimicking th...
Thrombin receptor peptide ligand
T80512
Thrombin receptor peptide ligand, a thrombin receptor antagonist, serves as an antithrombotic agent [1].
Heparin
T20654
Heparin (Adomiparin) is a mucopolysaccharide sulfate often used as an anticoagulant in clinical medicine.Heparin has shown partial anti-inflammatory activity in ...
Odiparcil
T16377
Odiparcil is an orally active beta-d-thioxyloside analog. Odiparcil is an indirect thrombin inhibitor that exerts its anticoagulant effect through activation of ...
OM-189
T12301
OM-189 is a selective inhibitor of synthetic thrombin.
Thrombin (MW 37kDa)
T19580
Thrombin (MW 37kDa) is a trypsin-like allosteric serine protease.
RWJ-445167
T12782
RWJ-445167 is a thrombin and factor Xa dual inhibitor(Ki of 4.0 nM and 230 nM, respectively), with potent antithrombotic activity.
Thrombin inhibitor 1
T10081
Thrombin inhibitor 1 is a potent inhibitor of thrombin (Ki: 0.66 nM, 2xaPTT=0.43 μM).
Heparin sodium salt
T6531
Heparin sodium is a sulfated polysaccharide, which belongs to the family of glycosaminoglycans. It is utilized as an anticoagulant and interacted with diverse pr...
Dabigatran Etexilate Mesylate
T5133
Dabigatran Etexilate Mesylate (BIBR 1048MS) is the orally active prodrug of dabigatran. Dabigatran is a reversible and selective, direct thrombin inhibitor (DTI,...
Eltrombopag Olamine
T6825
Eltrombopag Olamine (Eltrombopag diethanolamine salt) is the orally active ethanolamine salt of eltrombopag, a small-molecule, nonpeptide thrombopoietin receptor...
Edoxaban Tosylate Monohydrate
T2368
Edoxaban(DU-176) is an oral factor Xa (FXa) inhibitor in clinical development for stroke prevention.
Ozagrel hydrochloride
T6625
Ozagrel hydrochloride (OKY-046 HCl) is a selective thromboxane A(2) synthetase inhibitor used for the improvement of postoperative cerebrovascular contraction an...
Argatroban
T0155
Argatroban (MCI-9038), a specific thrombin inhibitor, which is a non-heparin anticoagulant, prevents the formation of thrombi.
NQ301
T3757
NQ301, an antithrombotic agent, inhibits collagen-challenged rabbit platelet aggregation (IC50: 10 mg/mL).
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TargetMol