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STAT

The JAK-STAT signalling pathway is a chain of interactions between proteins in a cell, and is involved in processes such as immunity, cell division, cell death and tumour formation. There are 4 JAK proteins: JAK1, JAK2, JAK3 and TYK2. JAKs contains a FERM domain (approximately 400 residues), an SH2-related domain (approximately 100 residues), a kinase domain (approximately 250 residues) and a pseudokinase domain (approximately 300 residues). The kinase domain is vital for JAK activity, since it allows JAKs to phosphorylate (add phosphate groups to) proteins.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T2505 S3I-201 501919-59-1 99.05%
S3I-201
S3I-201 (S3I-201) is a selective Stat3 inhibitor (IC50: 86±33 μM) and low effect towards STAT1/5.
T6537 HO-3867 1172133-28-6 99%
HO-3867
HO-3867, an analog of curcumin, is a sspecific STAT3 inhibitor.
T9646 Stafib-2 2097938-74-2 98.97%
Stafib-2
Stafib-2 is a potent and selective inhibitor of the transcription factor STAT5b.Stafib-2 inhibits STAT5b and STAT5a with IC50 values of 82 nM and 1.7 μM, respect...
T62491 STAT3-IN-13 2248552-86-3 98.89%
STAT3-IN-13
STAT3-IN-13 is a potent STAT3 inhibitor.STAT3-IN-13 has antiproliferative and anticancer activity and acts by binding to the structural domain of STAT3 SH2.STAT3...
T22142 RO8191 691868-88-9 98.85%
RO8191
RO8191 (CDM-3008) (CDM-3008), an imidazonaphthyridine compound, is an agonist of interferon (IFN) receptor.
T4650 C188-9 432001-19-9 98.83%
C188-9
C188-9 (TTI-101) is a Stat3 inhibitor with an IC50 of 4-7 μM.
T27613 InS3-54-A26 328998-77-2 98.83%
inS3-54-A26
inS3-54-A26 is an inhibitor of the DNA-binding domain of STAT3. inS3-54-A26 suppresses tumor growth, metastasis and the gene expression of STAT3.
T8476 RSVA405 140405-36-3 98.71%
RSVA405
RSVA405 is an AMPK activator (EC50 = 1 μM), and is STAT3 inhibitor
T6677 Sophocarpine 6483-15-4 98.67%
Sophocarpine
Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.
T3708 BP-1-102 1334493-07-0 98.61%
BP-1-102
BP-1-102 is an orally active, effective and specific STAT3 inhibitor. BP-1-102 binds Stat3 (Kd: 504 nM), then blocks Stat3-phosphotyrosine (pTyr) peptide interac...
T11807 L002 321695-57-2 98.59%
L002
L002 binds the acetyl-CoA pocket and competitively inhibits the FATp300 catalytic domain, blocks histone acetylation and p53 acetylation, and inhibits STAT3 acti...
T3380 Homoharringtonine 26833-87-4 98.59%
Homoharringtonine
Homoharringtonine (HHT) is an alkaloid inhibitor of protein synthesis with activity in myeloid malignancies. It might have clinical activity in some patients wit...
TN1237 3-O-Methylgallic acid 3934-84-7 98.53%
3-O-Methylgallic acid
3-O-Methylgallic acid (3,4-Dihydroxy-5-methoxybenzoic acid) reduces cell proliferation in Caco-2 cells(IC50 = 24.1 μM) more effectively than anthocyanins and may...
T3398 Icaritin 118525-40-9 98.50%
Icaritin
Icaritin (Anhydroicaritin) has hormone regulation activity and cardiovascular function improvement activity. Icaritin has anticancer activity, can induce S phase...
T4234 HJC0152 hydrochloride 1420290-99-8 98.33%
HJC0152 hydrochloride
HJC0152 hydrochloride (HJC0152) is a signal transducer and activator of transcription 3 (STAT3) inhibitor.
T4476 AS1517499 919486-40-1 98.27%
AS1517499
AS1517499 is a potent STAT6 inhibitor with IC50 of 21 nM
TN2346 Mogrol 88930-15-8 98.21%
Mogrol
Mogrol is a biometabolite of mogrosides. Mogrol acts via inhibition of the ERK1/2 and STAT3 pathways, or reducing CREB activation and activating AMPK signaling.
TQ0196 Cucurbitacin I 2222-07-3 98.2%
Cucurbitacin I
Cucurbitacin I (JSI-124), a natural compound, is a selective inhibitor of JAK2/STAT3 with anti-cancer activity.
T9339 Stafia-1 2582757-90-0 98.15%
Stafia-1
Stafia-1 is a potent STAT5a inhibitor ( IC50=22.2 μM). Stafia-1 displays high selectivity over STAT5b and other STAT family members.
T16940 STAT5-IN-2 2111834-61-6 98.02%
STAT5-IN-2
STAT5-IN-2 is an inhibitor of STAT5 with antileukemic effects (EC50s: 9 μM and 5 μM in K562 and KU812 cells, respectively).
S3I-201
T2505
S3I-201 (S3I-201) is a selective Stat3 inhibitor (IC50: 86±33 μM) and low effect towards STAT1/5.
HO-3867
T6537
HO-3867, an analog of curcumin, is a sspecific STAT3 inhibitor.
Stafib-2
T9646
Stafib-2 is a potent and selective inhibitor of the transcription factor STAT5b.Stafib-2 inhibits STAT5b and STAT5a with IC50 values of 82 nM and 1.7 μM, respect...
STAT3-IN-13
T62491
STAT3-IN-13 is a potent STAT3 inhibitor.STAT3-IN-13 has antiproliferative and anticancer activity and acts by binding to the structural domain of STAT3 SH2.STAT3...
RO8191
T22142
RO8191 (CDM-3008) (CDM-3008), an imidazonaphthyridine compound, is an agonist of interferon (IFN) receptor.
C188-9
T4650
C188-9 (TTI-101) is a Stat3 inhibitor with an IC50 of 4-7 μM.
inS3-54-A26
T27613
inS3-54-A26 is an inhibitor of the DNA-binding domain of STAT3. inS3-54-A26 suppresses tumor growth, metastasis and the gene expression of STAT3.
RSVA405
T8476
RSVA405 is an AMPK activator (EC50 = 1 μM), and is STAT3 inhibitor
Sophocarpine
T6677
Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.
BP-1-102
T3708
BP-1-102 is an orally active, effective and specific STAT3 inhibitor. BP-1-102 binds Stat3 (Kd: 504 nM), then blocks Stat3-phosphotyrosine (pTyr) peptide interac...
L002
T11807
L002 binds the acetyl-CoA pocket and competitively inhibits the FATp300 catalytic domain, blocks histone acetylation and p53 acetylation, and inhibits STAT3 acti...
Homoharringtonine
T3380
Homoharringtonine (HHT) is an alkaloid inhibitor of protein synthesis with activity in myeloid malignancies. It might have clinical activity in some patients wit...
3-O-Methylgallic acid
TN1237
3-O-Methylgallic acid (3,4-Dihydroxy-5-methoxybenzoic acid) reduces cell proliferation in Caco-2 cells(IC50 = 24.1 μM) more effectively than anthocyanins and may...
Icaritin
T3398
Icaritin (Anhydroicaritin) has hormone regulation activity and cardiovascular function improvement activity. Icaritin has anticancer activity, can induce S phase...
HJC0152 hydrochloride
T4234
HJC0152 hydrochloride (HJC0152) is a signal transducer and activator of transcription 3 (STAT3) inhibitor.
AS1517499
T4476
AS1517499 is a potent STAT6 inhibitor with IC50 of 21 nM
Mogrol
TN2346
Mogrol is a biometabolite of mogrosides. Mogrol acts via inhibition of the ERK1/2 and STAT3 pathways, or reducing CREB activation and activating AMPK signaling.
Cucurbitacin I
TQ0196
Cucurbitacin I (JSI-124), a natural compound, is a selective inhibitor of JAK2/STAT3 with anti-cancer activity.
Stafia-1
T9339
Stafia-1 is a potent STAT5a inhibitor ( IC50=22.2 μM). Stafia-1 displays high selectivity over STAT5b and other STAT family members.
STAT5-IN-2
T16940
STAT5-IN-2 is an inhibitor of STAT5 with antileukemic effects (EC50s: 9 μM and 5 μM in K562 and KU812 cells, respectively).
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TargetMol