T2505 |
S3I-201
|
501919-59-1
|
99.05%
|
|
S3I-201 (S3I-201) is a selective Stat3 inhibitor (IC50: 86±33 μM) and low effect towards STAT1/5.
|
T6537 |
HO-3867
|
1172133-28-6
|
99%
|
|
HO-3867, an analog of curcumin, is a sspecific STAT3 inhibitor.
|
T9646 |
Stafib-2
|
2097938-74-2
|
98.97%
|
|
Stafib-2 is a potent and selective inhibitor of the transcription factor STAT5b.Stafib-2 inhibits STAT5b and STAT5a with IC50 values of 82 nM and 1.7 μM, respect...
|
T62491 |
STAT3-IN-13
|
2248552-86-3
|
98.89%
|
|
STAT3-IN-13 is a potent STAT3 inhibitor.STAT3-IN-13 has antiproliferative and anticancer activity and acts by binding to the structural domain of STAT3 SH2.STAT3...
|
T22142 |
RO8191
|
691868-88-9
|
98.85%
|
|
RO8191 (CDM-3008) (CDM-3008), an imidazonaphthyridine compound, is an agonist of interferon (IFN) receptor.
|
T4650 |
C188-9
|
432001-19-9
|
98.83%
|
|
C188-9 (TTI-101) is a Stat3 inhibitor with an IC50 of 4-7 μM.
|
T27613 |
InS3-54-A26
|
328998-77-2
|
98.83%
|
|
inS3-54-A26 is an inhibitor of the DNA-binding domain of STAT3. inS3-54-A26 suppresses tumor growth, metastasis and the gene expression of STAT3.
|
T8476 |
RSVA405
|
140405-36-3
|
98.71%
|
|
RSVA405 is an AMPK activator (EC50 = 1 μM), and is STAT3 inhibitor
|
T6677 |
Sophocarpine
|
6483-15-4
|
98.67%
|
|
Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.
|
T3708 |
BP-1-102
|
1334493-07-0
|
98.61%
|
|
BP-1-102 is an orally active, effective and specific STAT3 inhibitor. BP-1-102 binds Stat3 (Kd: 504 nM), then blocks Stat3-phosphotyrosine (pTyr) peptide interac...
|
T11807 |
L002
|
321695-57-2
|
98.59%
|
|
L002 binds the acetyl-CoA pocket and competitively inhibits the FATp300 catalytic domain, blocks histone acetylation and p53 acetylation, and inhibits STAT3 acti...
|
T3380 |
Homoharringtonine
|
26833-87-4
|
98.59%
|
|
Homoharringtonine (HHT) is an alkaloid inhibitor of protein synthesis with activity in myeloid malignancies. It might have clinical activity in some patients wit...
|
TN1237 |
3-O-Methylgallic acid
|
3934-84-7
|
98.53%
|
|
3-O-Methylgallic acid (3,4-Dihydroxy-5-methoxybenzoic acid) reduces cell proliferation in Caco-2 cells(IC50 = 24.1 μM) more effectively than anthocyanins and may...
|
T3398 |
Icaritin
|
118525-40-9
|
98.50%
|
|
Icaritin (Anhydroicaritin) has hormone regulation activity and cardiovascular function improvement activity. Icaritin has anticancer activity, can induce S phase...
|
T4234 |
HJC0152 hydrochloride
|
1420290-99-8
|
98.33%
|
|
HJC0152 hydrochloride (HJC0152) is a signal transducer and activator of transcription 3 (STAT3) inhibitor.
|
T4476 |
AS1517499
|
919486-40-1
|
98.27%
|
|
AS1517499 is a potent STAT6 inhibitor with IC50 of 21 nM
|
TN2346 |
Mogrol
|
88930-15-8
|
98.21%
|
|
Mogrol is a biometabolite of mogrosides. Mogrol acts via inhibition of the ERK1/2 and STAT3 pathways, or reducing CREB activation and activating AMPK signaling.
|
TQ0196 |
Cucurbitacin I
|
2222-07-3
|
98.2%
|
|
Cucurbitacin I (JSI-124), a natural compound, is a selective inhibitor of JAK2/STAT3 with anti-cancer activity.
|
T9339 |
Stafia-1
|
2582757-90-0
|
98.15%
|
|
Stafia-1 is a potent STAT5a inhibitor ( IC50=22.2 μM). Stafia-1 displays high selectivity over STAT5b and other STAT family members.
|
T16940 |
STAT5-IN-2
|
2111834-61-6
|
98.02%
|
|
STAT5-IN-2 is an inhibitor of STAT5 with antileukemic effects (EC50s: 9 μM and 5 μM in K562 and KU812 cells, respectively).
|