T3711 |
RAF709
|
1628838-42-5
|
99.43%
|
|
RAF709 is a novel Raf kinase inhibitor with IC50s of 0.5 and 1.8 nM for c-Raf and b-Raf, respectively.
|
T8745 |
PROTAC BRAF-V600E degrader-1
|
2417296-84-3
|
99.43%
|
|
PROTAC BRAF-V600E degrader-1 (Compound 23) selectively induces degradation of BRAF-V600E but not wildtype BRAF.
|
T9693 |
TBAP-001
|
1777832-90-2
|
99.3%
|
|
TBAP-001 is a RAF kinase inhibitor, with an IC50 of 62 nM in BRAF V600E kinase assay and an IC50 of 18 nM in Cell-Based Phosho-ERK Assay.
|
T63644 |
Exarafenib
|
2639957-39-2
|
99.26%
|
|
Exarafenib (RAF/KIN_2787) is a potent and orally available pan-RAF inhibitor.Exarafenib has antitumor activity and acts by inhibiting downstream MAPK pathway sig...
|
T1892 |
Kobe2602
|
454453-49-7
|
99.24%
|
|
Kobe 2602 is an inhibitor of Ras that exhibits anticancer chemotherapeutic activities.
|
T2070 |
Agerafenib
|
1188910-76-0
|
99.23%
|
|
Agerafenib (CEP32496) is a highly potent inhibitor of BRAF.
|
T0093 |
Sorafenib tosylate
|
475207-59-1
|
99.2%
|
|
Sorafenib tosylate (Bay 43-9006) is a potent multikinase inhibitor (IC50s: 6/20/22 nM for Raf-1/VEGFR-3/B-Raf).
|
T6296 |
RAF265
|
927880-90-8
|
99.18%
|
|
RAF265 (CHIR-265) (CHIR-265) is a potent selective inhibitor of C-Raf/B-Raf/B-Raf V600E with IC50 of 3-60 nM, and exhibits potent inhibition on VEGFR2 phosphoryl...
|
T6052 |
GW 441756
|
504433-23-2
|
98.99%
|
|
GW 441756 is a specific Tropomyosin-related kinase A (TrkA) inhibitor with an IC50 value of 2 nM.
|
TP2358 |
KRPEP-2D acetate
|
TP2358
|
98.94%
|
|
KRPEP-2D acetate was identified as a K-Ras(G12D) selective inhibitory peptide against the G12D mutant of K-Ras, which is a key member of the Ras protein family a...
|
T1886 |
TAK-632
|
1228591-30-7
|
98.92%
|
|
TAK-632 is a potent pan-Raf inhibitor.
|
T6003 |
GSK1904529A
|
1089283-49-7
|
98.89%
|
|
GSK1904529A (GSK 4529) is a specific inhibitor of IGF-1R (IC50=27 nM) and IR(IC50=25 nM) .
|
T60029 |
SOS1-IN-11
|
2654741-64-5
|
98.79%
|
|
SOS1-IN-11 is an effective inhibitor of SOS1 (IC50 = 30 nM).
|
T2074 |
Raf inhibitor 1
|
1093100-40-3
|
98.78%
|
|
B-Raf inhibitor 1 (B-Raf inhibitor 1) is a potent and selective B-Raf inhibitor.
|
T9585 |
GNE-9815
|
2729996-45-4
|
98.73%
|
|
GNE-9815 (3-(2-cyanopropan-2-yl)-N-[2-fluoro-4-methyl-5-(7-methyl-8-oxo-7,8-dihydropyrido[2,3-d]pyridazin-3-yl)phenyl]benzamide) is a high kinase-selective inhib...
|
T5469 |
K-Ras-IN-1
|
84783-01-7
|
98.72%
|
|
K-Ras-IN-1 is a K-Ras inhibitor.
|
T11224 |
Rineterkib
|
1715025-32-3
|
98.4%
|
|
Rineterkib (ERK-IN-1) is an inhibitor of RAF and ERK1/2 activating mutations in the MAPK pathway.
|
T9755 |
MRTX0902
|
2654743-22-1
|
98.37%
|
|
MRTX0902 is an effective and high selective inhibitor of SOS1 with an IC50 of 46 nM and a Ki of 2 nM.
|
T2327 |
Pelitinib
|
257933-82-7
|
98.37%
|
|
Pelitinib (EKB-569) (EKB-569) is an effective irreversible EGFR inhibitor (IC50: 38.5 nM).
|
T6556 |
K-Ras(G12C) inhibitor 9
|
1469337-91-4
|
98.31%
|
|
K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C).
|