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PKC

Protein kinase C, commonly abbreviated to PKC, is a family of protein kinase enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins, or a member of this family. PKC enzymes in turn are activated by signals such as increases in the concentration of diacylglycerol (DAG) or calcium ions (Ca2+). Hence PKC enzymes play important roles in several signal transduction cascades.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
TN3655 Cimiside E 154822-57-8 98%
Cimiside E
Cimiside E has anti-inflammatory activity, it selectively inhibits TNF-α-induced expression of VCAM-1 at least by upregulation of PPAR-γ, and signals for ERK1/2,...
TN3160 6-Deoxyisojacareubin 26486-92-0 98%
6-Deoxyisojacareubin
6-Deoxyisojacareubin shows moderate inhibitory activity against the QGY-7703 cell line, with the IC50 value of 9.65 uM; it also possesses potency in the inhibiti...
T11740 Delcasertib 949100-39-4 99.96%
Delcasertib
Delcasertib is a potent and selective inhibitor of δ-protein kinase C (δPKC).
T6680 Staurosporine 62996-74-1 99.87%
Staurosporine
Staurosporine is a potent PKC inhibitor for PKCα/γ/η (IC50: 2/5/4 nM), less potent to PKCε (73 nM), PKCδ (20 nM) and little action to PKCζ (1086 nM).
TQ0198 Phorbol 12-myristate 13-acetate 16561-29-8 99.87%
Phorbol 12-myristate 13-acetate
Phorbol 12-myristate 13-acetate (PMA) is a dual SphK and PKC activator.
T5239 Cholesteryl sulfate sodium 2864-50-8 99.82%
Cholesteryl sulfate sodium
Cholesteryl sulfate sodium (Sodium Cholesteryl Sulfate) is a sterol sulfate in human plasma. Cholesteryl sulfate sodium is a component of cell membrane and has a...
T2851 Daphnetin 486-35-1 99.82%
Daphnetin
Daphnetin, a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM), and PKC (IC50: 25.01 μM), ...
T14069 A-3 hydrochloride 78957-85-4 99.79%
A-3 hydrochloride
A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. A-3 hydrochloride also inhibits PKC and c...
T1911 Afuresertib 1047644-62-1 99.77%
Afuresertib
Afuresertib is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity.
T0465 Ellagic acid 476-66-4 99.76%
Ellagic acid
Ellagic acid is a fused four ring compound isolated from the kino of Eucalyptus maculata Hook and E. Hemipholia F. Muell. Activates Factor XII of the blood clott...
T9863 PKCiota-IN-2 2230055-52-2 99.74%
PKCiota-IN-2
PKCiota-IN-2 is a selective and potent PKCiota (PKC-ι) inhibitor with an IC50 of 2.8 nM. PKCiota-IN-2 also inhibits PKC-α and PKC-ε with IC50s of 71 nM and 350 n...
T4950 1,2-Dipalmitoyl-sn-glycerol 30334-71-5 99.74%
1,2-Dipalmitoyl-sn-glycerol
1,2-Dipalmitoyl-sn-glycerol is an analog of the PKC-activating second messenger diacylglycerol (DAG). It weakly activates PKC.
T2441 TAS-301 193620-69-8 99.69%
TAS-301
TAS-301, an inhibitor of smooth muscle cell migration and proliferation, inhibits intimal thickening after balloon injury to rat carotid arteries.
T7648 HA-100 84468-24-6 99.69%
HA-100
HA-100 is an inhibitor of protein kinase
T20168 Aurothiomalate sodium 12244-57-4 99.66%
Aurothiomalate sodium
Sodium aurothiomalate is a gold compound that is used for its immunosuppressive anti-rheumatic effects. Aurothiomalate sodium is a potent and selective inhibitor...
TN1557 Decursinol angelate 130848-06-5 99.65%
Decursinol angelate
Decursinol angelate has anti-tumor, anti-inflammatory, anti-oxidant, and hepatoprotective activities, it inhibits VEGF-induced angiogenesis via suppression of th...
T7501 Iso-H7 dihydrochloride 140663-38-3 99.64%
Iso-H7 dihydrochloride
Iso-H7 dihydrochloride is a less potent inhibitor of phosphokinase C than H-7.
TN1513 Clitorin 55804-74-5 99.63%
Clitorin
Clitorin has free radical scavenging property. It shows significant interactions with CD38, it may have anti-hyperglycemic potential.
TP1945L1 Pep2m, myristoylated acetate TP1945L1 99.62%
Pep2m, myristoylated acetate
Pep2m, myristoylated acetate is a Cell-permeable, myristoylated form of pep2m. Peptide inhibitor of the interaction between the C-terminus of the GluA2 (AMPA rec...
T3050 ML-7 hydrochloride 110448-33-4 99.61%
ML-7 hydrochloride
ML-7 hydrochloride (ML-7 HCl) is a cell-permeable, reversible, effective, ATP-competitive, and specific inhibitor of myosin light chain kinase (Ki: 300 nM); also...
Cimiside E
TN3655
Cimiside E has anti-inflammatory activity, it selectively inhibits TNF-α-induced expression of VCAM-1 at least by upregulation of PPAR-γ, and signals for ERK1/2,...
6-Deoxyisojacareubin
TN3160
6-Deoxyisojacareubin shows moderate inhibitory activity against the QGY-7703 cell line, with the IC50 value of 9.65 uM; it also possesses potency in the inhibiti...
Delcasertib
T11740
Delcasertib is a potent and selective inhibitor of δ-protein kinase C (δPKC).
Staurosporine
T6680
Staurosporine is a potent PKC inhibitor for PKCα/γ/η (IC50: 2/5/4 nM), less potent to PKCε (73 nM), PKCδ (20 nM) and little action to PKCζ (1086 nM).
Phorbol 12-myristate 13-acetate
TQ0198
Phorbol 12-myristate 13-acetate (PMA) is a dual SphK and PKC activator.
Cholesteryl sulfate sodium
T5239
Cholesteryl sulfate sodium (Sodium Cholesteryl Sulfate) is a sterol sulfate in human plasma. Cholesteryl sulfate sodium is a component of cell membrane and has a...
Daphnetin
T2851
Daphnetin, a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM), and PKC (IC50: 25.01 μM), ...
A-3 hydrochloride
T14069
A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. A-3 hydrochloride also inhibits PKC and c...
Afuresertib
T1911
Afuresertib is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity.
Ellagic acid
T0465
Ellagic acid is a fused four ring compound isolated from the kino of Eucalyptus maculata Hook and E. Hemipholia F. Muell. Activates Factor XII of the blood clott...
PKCiota-IN-2
T9863
PKCiota-IN-2 is a selective and potent PKCiota (PKC-ι) inhibitor with an IC50 of 2.8 nM. PKCiota-IN-2 also inhibits PKC-α and PKC-ε with IC50s of 71 nM and 350 n...
1,2-Dipalmitoyl-sn-glycerol
T4950
1,2-Dipalmitoyl-sn-glycerol is an analog of the PKC-activating second messenger diacylglycerol (DAG). It weakly activates PKC.
TAS-301
T2441
TAS-301, an inhibitor of smooth muscle cell migration and proliferation, inhibits intimal thickening after balloon injury to rat carotid arteries.
HA-100
T7648
HA-100 is an inhibitor of protein kinase
Aurothiomalate sodium
T20168
Sodium aurothiomalate is a gold compound that is used for its immunosuppressive anti-rheumatic effects. Aurothiomalate sodium is a potent and selective inhibitor...
Decursinol angelate
TN1557
Decursinol angelate has anti-tumor, anti-inflammatory, anti-oxidant, and hepatoprotective activities, it inhibits VEGF-induced angiogenesis via suppression of th...
Iso-H7 dihydrochloride
T7501
Iso-H7 dihydrochloride is a less potent inhibitor of phosphokinase C than H-7.
Clitorin
TN1513
Clitorin has free radical scavenging property. It shows significant interactions with CD38, it may have anti-hyperglycemic potential.
Pep2m, myristoylated acetate
TP1945L1
Pep2m, myristoylated acetate is a Cell-permeable, myristoylated form of pep2m. Peptide inhibitor of the interaction between the C-terminus of the GluA2 (AMPA rec...
ML-7 hydrochloride
T3050
ML-7 hydrochloride (ML-7 HCl) is a cell-permeable, reversible, effective, ATP-competitive, and specific inhibitor of myosin light chain kinase (Ki: 300 nM); also...
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TargetMol