Nrf2

Nuclear factor erythroid 2-related factor 2 (NRF2), also known as nuclear factor erythroid-derived 2-like 2, is a transcription factor that in humans is encoded by the NFE2L2 gene. NRF2 is a basic leucine zipper (bZIP) protein that regulates the expression of antioxidant proteins that protect against oxidative damage triggered by injury and inflammation. Several drugs that stimulate the NFE2L2 pathway are being studied for treatment of diseases that are caused by oxidative stress.

Cat. No.	Product name	CAS No.	Purity
T3849	Kinsenoside	151870-74-5	99.92%
T3849	Kinsenoside ((+)-Kinsenoside) shows significant antihepatotoxic, and anti-inflammatory activities. Kinsenoside could be useful for repairing beta cells in pancre...
T1558	Resveratrol	501-36-0	99.9%
T1558	Resveratrol (SRT 501) is a polyphenolic natural product, a plant antitoxin with antioxidant and chemopreventive activities. Resveratrol has a wide range of targe...
T13436	(E)-[6]-Dehydroparadol	878006-06-5	99.87%
T13436	(E)-[6]-Dehydroparadol ((6)-Dehydroparadol), an oxidative metabolite of [6]-Shogaol, is a potent Nrf2 activator.
T4360	ML385	846557-71-9	99.85%
T4360	ML385 is an NRF2 inhibitor (IC50=1.9 μM) with novelty and specificity. ML385 has anti-inflammatory activity by modulating anti-oxidative stress through the inhib...
TQ0211	Brusatol	14907-98-3	99.82%
TQ0211	Brusatol (NSC-172924) is a natural product isolated from the Brucea javanica plant. It inhibits Nrf2.
TQ0207	Sulforaphane	4478-93-7	99.79%
TQ0207	Sulforaphane is derived from the consumption of cruciferous vegetables, such as broccoli. It has shown anticancer and cardioprotective activities.
T3717	Hinokitiol	499-44-5	99.78%
T3717	Hinokitiol (4-Isopropyltropolone) can inhibit ultraviolet B-induced apoptosis in keratinocytes and strongly suggest that the inhibitory mechanism is due to the a...
T2794	Astilbin	29838-67-3	99.76%
T2794	Astilbin (Neoastilbin) is actions Flavonoid phytochemical found in St. John′s wort and Traditional Chinese Medicine herbal preparations.
T30087	Antroquinonol	1010081-09-0	99.76%
T30087	Antroquinonol is a ubiquinone derivative from Antrodia camphorata with anti-inflammatory and anticancer activities.Antroquinonol reduces oxidative stress and inh...
T60487	DDO-7263	2254004-96-9	99.75%
T60487	DDO-7263 is a 1,2,4-Oxadiazole derivative that upregulates Nrf2 through binding to Rpn6 to block the assembly of 26S proteasome and the subsequent degradation of...
T8704	4-hydroxyphenyl acetate	3233-32-7	99.72%
T8704	4-Acetoxyphenol Prevents RPE Oxidative Stress-Induced Necrosis by Functioning as an NRF2 Stabilizer
TQ0199	Ginsenoside Rh3	105558-26-7	99.57%
TQ0199	Ginsenoside Rh3 is a natural product extracted from Ginseng C. A. Mey.Ginsenoside Rh3 has antifungal and antioxidant activities and induces Nrf2 activation in hu...
T0153	Oltipraz	64224-21-1	99.56%
T0153	Oltipraz (RP 35972) is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties. Oltipraz induces phase II detoxification enzymes...
T78650	Nrf2 activator-3	2766570-23-2	99.54%
T78650	Nrf2 activator-3 is a potent Nrf2 activator with potential anti-inflammatory, antioxidant and anti-tumor activity, which can be used to study neurological and im...
TN1621	Eriodictyol-7-O-glucoside	38965-51-4	99.53%
TN1621	Eriodictyol-7-O-glucoside is an Nrf2 activator conferring protection against Cisplatin-induced toxicity. Eriodictyol-7-O-glucoside is a flavonoid and a free radi...
T6S1587	Notoginsenoside R2	80418-25-3	99.37%
T6S1587	Notoginsenoside R2 (20(S)-Notoginsenoside R2) has neuroprotection against 6-OHDA-induced neurotoxicity, is associated with Notoginsenoside R2-mediated P90RSK and...
T12253	Nrf2-IN-1	1610022-76-8	99.36%
T12253	Nrf2-IN-1 is an nuclear factor-erythroid 2-related factor 2 (Nrf2) inhibitor. Nrf2-IN-1 is developed for the research of acute myeloid leukemia (AML).
TN4234	Hydrangenol	480-47-7	99.33%
TN4234	Hydrangenol is a natural product and can be isolated from Hydrangea serrata leaves. Hydrangenol is an antiphotoaging compound with oral activity. Hydrangenol can...
T16331	NK-252	1414963-82-8	99.32%
T16331	NK-252 is a potential activator of Nrf2. It has great Nrf2-activating potential.
TN6750	2-tert-Butyl-1,4-benzoquinone	3602-55-9	99.29%
TN6750	2-tert-Butyl-1,4-benzoquinone (TBQ), an electrophilic metabolite of butylated hydroxyanisole (BHA), causes activation of Nrf2 together with S-arylation of its ne...