MAPK

A mitogen-activated protein kinase (MAPK or MAP kinase) is a type of protein kinase that is specific to the amino acids serine and threonine (i.e., a serine/threonine-specific protein kinase). MAPKs are involved in directing cellular responses to a diverse array of stimuli, such as mitogens, osmotic stress, heat shock and proinflammatory cytokines. They regulate cell functions including proliferation, gene expression, differentiation, mitosis, cell survival, and apoptosis.

Cat. No.	Product name	CAS No.	Purity
T2382	Vemurafenib	918504-65-1	99.65%
T2382	Vemurafenib (RG7204) is a B-RAF inhibitor that inhibits RAFV600E and c-RAF-1 (IC50=31/48 nM) selectively and potently. Vemurafenib exhibits antitumor activity an...
T5483	DMX-5804	2306178-56-1	99.63%
T5483	DMX-5804 is a potent, selective MAP4K4 inhibitor, with an IC50 of 3 nM.DMX-5804 enhances cardiomyocyte survival, and reduces ischemia-reperfusion injury in mice....
T3410	Momordin Ic	96990-18-0	99.61%
T3410	Momordin Ic (Momordin 1c) might represent a potential anticancer activity, by inducing apoptosis through oxidative stress-regulated mitochondrial dysfunction inv...
T5190	GS-444217	1262041-49-5	99.58%
T5190	GS-444217 is a selective ATP-competitive inhibitor of apoptosis signal-regulating kinase 1 (ASK1, IC50: 2.87 nM).
T4221	PF-06260933	1811510-56-1	99.52%
T4221	PF-06260933 is a highly selective small-molecule MAP4K4 inhibitor with IC50s of 3.7 and 160 nM for kinase and cell, respectively.
T11942	MAP4K4-IN-3	1811510-58-3	99.5%
T11942	MAP4K4-IN-3 (Compound 17) may be a viable target for antidiabetic agents, a serine/threonine protein kinase.
T4011	NCB-0846	1792999-26-8	99.46%
T4011	NCB-0846 is an orally active TNIK inhibitor (IC50: 21 nM).
T16987	TAO Kinase inhibitor 1	850467-66-2	99.45%
T16987	TAO Kinase inhibitor 1 delays mitosis and induces mitotic cell death. TAO Kinase inhibitor 1 is a selective and ATP-competitive thousand-and-one amino acid kinas...
T9377	ASK1-IN-2	2541792-70-3	99.36%
T9377	ASK1-IN-2 is a potent and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with an IC50 of 32.8 nM. ASK1-IN-2 can potentially be used as a...
T9470	HPK1-IN-7	2320462-65-3	99.31%
T9470	HPK1-IN-7 is an orally active HPK1 inhibitor. It shows selectivity against IRAK4 (59 nM) and GLK (140 nM).
TQ0079	GNE-495	1449277-10-4	99.22%
TQ0079	GNE-495 is a potent and specific MAP4K4 inhibitor (IC50: 3.7 nM).
T10865	Cot inhibitor-1	915365-57-0	99.19%
T10865	Cot inhibitor-1 is a selective inhibitor of Cot protein kinase (also known as Tpl2 or MAP3K8) (IC50 at 28 nM). Cot inhibitor-1 inhibited TNF-alpha production in ...
T12058	MK2-IN-3 hydrate	1186648-22-5	99.14%
T12058	MK2-IN-3 hydrate (MK-2 Inhibitor III) is an orally active, selective, and ATP-competitive inhibitor of MAPKAP-K2 (MK-2) (IC50 of 0.85 nM)
T16501	PF-3644022	1276121-88-0	99.12%
T16501	PF-3644022 is an effective, selective, and ATP-competitive MAPKAPK2 (MK2) inhibitor (IC50: 5.2 nM and a Ki of 3 nM). PF-3644022 potently inhibits TNFα production...
T3350	Selonsertib	1448428-04-3	98.97%
T3350	Selonsertib (GS-4997) is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and an...
TN1445	Bisabolangelone	30557-81-4	98.91%
TN1445	Bisabolangelone has anti-tumor, anti-inflammatory, anti-microbial, and antioxidant activities, it inhibits dendritic cell functions by blocking MAPK and NF-κB si...
TN2081	Maohuoside A	128988-55-6	98.91%
TN2081	Maohuoside A promotes osteogenesis of rat mesenchymal stem cells via BMP and MAPK signaling pathways.
T60657	(R)-STU104	2767124-77-4	98.91%
T60657	(R)-STU104 is a novel TAK1-MKK3 protein-protein interaction (PPI) inhibitor that inhibits TNF-α and suppresses the TAK1/MKK3/p38/MnK1/MK2/elF4E signalling pathwa...
T10866	Cot inhibitor-2	915363-56-3	98.87%
T10866	Cot inhibitor-2 is a cot (Tpl2/MAP3K8) inhibitor (IC50: 1.6 nM) with potency, selectivity and oral activity. cot inhibitor-2 inhibits LPS-stimulated TNF-α produc...
T3836	Eudesmin	526-06-7	98.86%
T3836	Eudesmin shows antiinflammatory, neuritogenic, anticonvulsant and sedative effects, the mechanism of eudesmin may be related to up-regulation of GABAA and GAD65 ...