EGFR

The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members of the epidermal growth factor family (EGF family) of extracellular protein ligands.

Cat. No.	Product name	CAS No.	Purity
T2600	AG490	133550-30-8	99.7%
T2600	AG490 (Tyrphostin B42) is an inhibitor of EGFR (IC50: 0.1 μM). It is 135-fold more selective for EGFR than ErbB2, also inhibits JAK2 with no effect to Lyn, Lck, ...
T35916	Simotinib	944258-89-3	99.7%
T35916	Simotinib (AL-6802) is a selective and orally bioactive EGFR tyrosine kinase inhibitor (IC50: 19.9 nM) with anti-tumour activity for the study of non-small cell ...
T9304	(S)-Sunvozertinib	2370013-49-1	99.69%
T9304	(S)-Sunvozertinib (DZD9008) is a rationally designed selective, irreversible EGFR/HER2 inhibitor.
T8758	Poziotinib hydrochloride	1429757-68-5	99.69%
T8758	Poziotinib hydrochloride irreversibly inhibits EGFR (HER1 or ErbB1), including EGFR mutants, HER2, and HER4, thereby inhibiting the proliferation of tumor cells ...
T1737	Genistein	446-72-0	99.69%
T1737	Genistein (NPI 031L) is an isoflavonoid derived from soy products. It inhibits protein-tyrosine kinase and topoisomerase-II (DNA TOPOISOMERASES, TYPE II), with a...
T5155	(E)-AG 99	122520-85-8	99.67%
T5155	(E)-AG 99 ((E)-Tyrphostin AG 99) is an inhibitor of EGFR kinase (IC50: 10 μM in the human epidermoid carcinoma cell line A431).
T1773	Afatinib Dimaleate	850140-73-7	99.66%
T1773	Afatinib Dimaleate (BIBW 2992MA2) is an orally bioavailable anilino-quinazoline derivative and inhibitor of the receptor tyrosine kinase (RTK) epidermal growth f...
T2959	Ginsenoside Rh2	78214-33-2	99.65%
T2959	Ginsenoside Rh2 (20(S)-Ginsenoside Rh2), an extract of red Panax ginseng, is a potent anti-inflammatory and anticancer drug.
T67385	Neratinib maleate	915942-22-2	99.64%
T67385	Neratinib maleate (HKI-272 maleate) is an irreversible, orally active and highly selective inhibitor of HER2 and EGFR with IC50 values of 59 nM and 92 nM, respec...
T11161	EGFR-IN-7	2267329-76-8	99.64%
T11161	EGFR-IN-7 (TQB3804) is a selective and potent EGFR kinase inhibitor.
T22254	Alflutinib	1869057-83-9	99.61%
T22254	Alflutinib (ASK120067) is an inhibitor of EGFR, and its targets including EGFR activating mutations and T790M, thus leading to tumor growth inhibition.
T16369	O-Desmethyl gefitinib	847949-49-9	99.6%
T16369	O-Desmethyl gefitinib inhibits EGFR (IC50: 36 nM in subcellular assays). In human plasma, O-Desmethyl gefitinib is an active metabolite of Gefitinib. The formati...
TN1440	Beta-Hydroxyisovalerylshikonin	7415-78-3	99.59%
TN1440	Beta-Hydroxyisovalerylshikonin is an inhibitor of protein-tyrosine kinases such as v-Src and EGFR, and has been shown to induce apoptosis in several human tumor ...
T2035	WHI-P258	21561-09-1	99.59%
T2035	WHI-P258 is a dimethoxyquinazoline inhibitor of JAK3. This compound binds JAK3 weakly and may be used as a JAK-binding negative control in the development of new...
T3554	RG14620	136831-49-7	99.56%
T3554	RG14620 (Tyrphostin RG14620) is an epidermal growth factor receptor (EGFR) inhibitor.
T6227	Benidipine hydrochloride	91599-74-5	99.56%
T6227	Benidipine hydrochloride (Coniel) , a hydrochloride salt form of benidipine, is used as a blocker of dihydropyridine calcium channel.
T10782	CGP52411	145915-58-8	99.56%
T10782	CGP52411 is an orally active, and ATP-competitive inhibitor of EGFR (IC50: 0.3 μM). CGP52411 blocks the toxic influx of Ca2+ ions into neuronal cells and dramati...
T3634	Osimertinib mesylate	1421373-66-1	99.53%
T3634	Osimertinib mesylate (Mereletinib mesylate) is an irreversible and mutant selective EGFR inhibitor (IC50s: 12/1 nM for EGFR(L858R) and EGFR(L858R/T790M)).
T0373L	Erlotinib hydrochloride	183319-69-9	99.52%
T0373L	Erlotinib hydrochloride (NSC 718781) is an EGFR inhibitor (IC50: 2 nM). It is used for the treatment of non-small cell lung cancer.
T22431	SU5204	186611-11-0	99.5%
T22431	SU5204 (3-[(2-Ethoxyphenyl)methylidene]-1H-indol-2-one), an analogue of SU5025, pharmacologically inhibits VEGFR2(IC50s of 4 and 51.5 μM for FLK-1 (VEGFR-2) and ...