CDK

Cyclin-dependent kinases (CDKs) are the families of protein kinases first discovered for their role in regulating the cell cycle. They are also involved in regulating transcription, mRNA processing, and the differentiation of nerve cells.They are present in all known eukaryotes, and their regulatory function in the cell cycle has been evolutionarily conserved.

Cat. No.	Product name	CAS No.	Purity
T8484	JSH-150	2247481-21-4	99.96%
T8484	JSH-150 is a highly selective CDK9 inhibitor(IC50 : 1 nM).
T3186	NU2058	161058-83-9	99.95%
T3186	NU2058 (O(6)-Cyclohexylmethylguanine) is a guanine-based CDK inhibitor, also inhibits DNA topoisomerase II ATPase activity.
T3700	SCH900776 (S-isomer)	891494-64-7	99.95%
T3700	SCH900776 S-isomer (MK-8776 S-isomer) is an effective, specific and orally bioavailable inhibitor of checkpoint kinase Chk1 (IC50: 3 nM). It also inhibitors Chk2...
T14914	Cdk1/2 Inhibitor III	443798-55-8	99.94%
T14914	Cdk1/2 Inhibitor III is a selective Cdk1/2 inhibitor with an IC50 value of 2.1 μM against CDK1/cyclin B.
T6167	SU9516	377090-84-1	99.94%
T6167	SU9516 is a potent CDK2 inhibitor, with an IC50 of 22 nM, and also has inhibitory effects on CDK1 and CDK4, with IC50s of 40 nM and 200 nM, respectively.
T6940	PHA-767491 hydrochloride	942425-68-5	99.92%
T6940	PHA-767491 hydrochloride (CAY-10572 hydrochloride) is an effective ATP-competitive dual Cdc7/CDK9 inhibitor (IC50: 10/34 nM). It has ~20-fold selectivity against...
T8819	SU-9516	666837-93-0	99.91%
T8819	SU9516 is a selectively potent ATP-competitive inhibitor of CDKs.
T1917	GSK 3 Inhibitor IX	667463-62-9	99.9%
T1917	GSK 3 Inhibitor IX (6-BIO) is a selective reversible, ATP-competitive inhibitor of GSK-3α/β and CDK1-cyclinB complex. It inhibits (GSK-3α/β)/CDK1/CDK5 activity w...
T10096L	Voruciclib	1000023-04-0	99.89%
T10096L	Voruciclib is an orally active and selective CDK inhibitor (Ki: 0.626 nM-9.1 nM). Voruciclib represses the expression of MCL-1 in multiple models of diffuse larg...
T1778	AT7519 Hydrochloride	902135-91-5	99.88%
T1778	AT7519 Hydrochloride (AT7519 HCl) is a multi-CDK inhibitor for CDK1, 2, 4, 6 and 9.
T2118	SC-514	354812-17-2	99.88%
T2118	SC-514 (GK 01140) is a selective, orally active, ATP-competitive IKK-2 inhibitor (IC50=11.2±4.7 μM), obstructs NF-κB-dependent gene expression.
T2615	Flavopiridol hydrochloride	131740-09-5	99.88%
T2615	Flavopiridol hydrochloride (MDL 107826A) is a synthetic N-methylpiperidinyl chlorophenyl flavone compound. As an inhibitor of cyclin-dependent kinase, alvocidib ...
T2381	Abemaciclib	1231929-97-7	99.87%
T2381	Abemaciclib (LY2835219) is a dual inhibitor of CDK4/6 (IC50=2/10 nM) with selectivity and specificity. Abemaciclib has antitumor activity and is used to treat ad...
T2440	IC261	186611-52-9	99.86%
T2440	IC261 (SU-5607) is a novel inhibitor of CK1, triggers the mitotic checkpoint control. The IC50 of IC261 for CK1 was 16 μM and for Cdk5 is 4.5 mM.
T3971	CASIN	425399-05-9	99.86%
T3971	CASIN (Pirl1-related Compound 2) is a specific inhibitor of GTPase Cdc42 (IC50: 2 uM).
T6612	NU6027	220036-08-8	99.85%
T6612	NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-aminopurin...
T6199	Ribociclib	1211441-98-3	99.85%
T6199	Ribociclib (LEE011) is an orally available, and highly specific CDK4/6 inhibitor (IC50：10/39 nM).
T6240	Palbociclib Isethionate	827022-33-3	99.85%
T6240	Palbociclib Isethionate (PD 0332991 isethionate) is a selective inhibitor of CDK4/6 (IC50s: 11/16 nM). It exhibits no inhibition against a panel of 36 additional...
T6837	Flavopiridol	146426-40-6	99.85%
T6837	Flavopiridol (Alvocidib) (Alvocidib) competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM. It is 7.5-fold more selective fo...
T79404	A09-003	2911646-14-3	99.84%
T79404	A09-003 is a novel cell cycle protein-dependent kinase-9 CDK-9 inhibitor.A09-003 inhibits the proliferation of a variety of leukemia cell lines and inhibits the ...