CDK

Cyclin-dependent kinases (CDKs) are the families of protein kinases first discovered for their role in regulating the cell cycle. They are also involved in regulating transcription, mRNA processing, and the differentiation of nerve cells.They are present in all known eukaryotes, and their regulatory function in the cell cycle has been evolutionarily conserved.

Cat. No.	Product name	CAS No.	Purity
T10546	Bio-THZ1	1604811-14-4	98%
T10546	bio-THZ1 is a biotinylated version of THZ1. THZ1 is a selective and irreversibly covalent CDK7 inhibitor (IC50: 3.2 nM).
T13153	THZ1-R	1621523-07-6	98%
T13153	THZ1-R displays diminished activity for CDK7 inhibition(Kd:142 nM).
T12355	Palbociclib-d8	1628752-83-9	98%
T12355	Palbociclib D8 is a deuterium labeled Palbociclib. Palbociclib is a selective and orally active inhibitor of CDK4 and CDK6 (IC50s of 11 and 16 nM, respectively)....
T10382	AS2863619 free base	2241300-50-3	98%
T10382	AS2863619 free base enables the conversion of antigen-specific effector/memory T cells into Foxp3+ regulatory T (Treg) cells. It is a potent, orally active CDK8 ...
T13202L	Trilaciclib	1374743-00-6	98%
T13202L	Trilaciclib is an inhibitor of CDK4/6 (IC50s: 1 nM and 4 nM for CDK4 and CDK6, respectively).
TL0017	Aristolactam AIIIa	97399-91-2	98%
TL0017	Aristolactam AIIIa is a new type of Plk1 inhibitors, targeting the Polo Box domain (PBD), it has anti-tumor activity. Aristolactam IIIa shows inhibition of plate...
T10464	Atuveciclib	2923012-24-0	98%
T10464	Atuveciclib (BAY-1143572) is a potent and highly selective, oral PTEFb / CDK9 inhibitor that inhibits CDK9 / CycT1 with an IC 50 of 13 nM [1].
TN1728	Hellebrigenin	465-90-7	98%
TN1728	Hellebrigenin has anti-hepatoma activities, it induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells through inhibition of Akt. H...
T15731	Ribociclib succinate hydrate	1374639-79-8	98%
T15731	Ribociclib succinate hydrate is a highly specific CDK4/6 inhibitor (IC50s: 10 nM and 39 nM, respectively). It also is over 1,000-fold less potent against the cyc...
TN3673	Clausine Z	866111-14-0	98%
TN3673	Clausine Z exhibits inhibitory activity against cyclin-dependent kinase 5 (CDK5) and shows protective effects on cerebellar granule neurons in vitro.
T11655	Indomethacin-D4	87377-08-0	98%
T11655	Indomethacin-D4 is a deuterium labeled Indomethacin. Indomethacin is a potent and nonselective inhibitor of COX1 and COX2, with IC50s of 18 nM and 26 nM for huma...
T10465	Atuveciclib S-Enantiomer	2250279-81-1	98%
T10465	Atuveciclib S-Enantiomer (BAY-1143572 S-Enantiomer) is the (S)-enantiomer of BAY-1143572. Atuveciclib S-Enantiomer is a potent and selective CDK9 inhibitor, whic...
T10836	CLK1-IN-1	2123491-32-5	98%
T10836	CLK1-IN-1 is a potent and selective inhibitor of the Cdc2-like kinase 1 (CLK1; IC50: 2 nM).
T14915	CDK12-IN-E9	2020052-55-3	98%
T14915	CDK12-IN-E9 is a potent and selective covalent CDK12 inhibitor and non-covalent CDK9 inhibitor while avoiding ABC transporter-mediated efflux. It has a weak bind...
T10096	(2S,3R)-Voruciclib	1253731-24-6	98%
T10096	(2S,3R)-Voruciclib is the (2S,3R)-enantiomer of Voruciclib. It is an orally active CDK inhibitor.
T13696	FN-1501-propionic acid	2408642-48-6	98%
T13696	FN-1501-propionic acid, a CDK2/9 ligand, in conjunction with a CRBN ligand, has been utilized in the design of a PROTAC CDK2/9 degrader.
T22440	TP-353	1253799-29-9	99.98%
T22440	TP-353 (EOS-61973) is a CDK7 inhibitor.
T11960	MBM-55	2083622-09-5	99.98%
T11960	MBM-55 is an effective inhibitor of NIMA related kinase 2 (NEK2) with an IC50 of 1 nM. MBM-55 effectively inhibits the proliferation of cancer cells by inducing...
T6162	BS-181 hydrochloride	1397219-81-6	99.97%
T6162	BS-181 hydrochloride (BS-181 HCl) is a highly selective CDK7 inhibitor with IC50 of 21 nM. It is more than 40-fold selective for CDK7 than CDK1, 2, 4, 5, 6, or 9...
T3186	NU2058	161058-83-9	99.95%
T3186	NU2058 (O(6)-Cyclohexylmethylguanine) is a guanine-based CDK inhibitor, also inhibits DNA topoisomerase II ATPase activity.