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BCL

Bcl-2 (B-cell lymphoma 2), encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 family of regulator proteins that regulate cell death (apoptosis), by either inhibiting (anti-apoptotic) or inducing (pro-apoptotic) apoptosis.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
TN2191 Scutebarbatine A 176520-13-1 98%
Scutebarbatine A
Scutebarbatine A shows significant antitumor effects on A549 cells in vivo and in vitro via mitochondria-mediated apoptosis by up-regulating expressions of caspa...
TN2116 Pteropodine 5629-60-7 98%
Pteropodine
Pteropodine acts as a positive modulator of muscarinic M(1) and 5-HT(2) receptors. Pteropodine shows antigenotoxic, antioxidant and lymphocyte induction effects,...
TN1875 Liriodenine 475-75-2 98%
Liriodenine
Liriodenine is a potent inhibitor of topoisomerase II (EC 5.99.1.3) both in vivo and in vitro, it has antitumor, antibacterial and antifungal activities, it can ...
T16042 Metaldehyde 108-62-3 98%
Metaldehyde
Metaldehyde is used for snails and other gastropods pesticide against.
T11974 Mcl1-IN-12 2042211-12-9 98%
Mcl1-IN-12
Mcl1-IN-12 has anti-tumor activity.It is a selective Mcl-1 inhibitor, less potent at Bcl-2, with Kis of 0.29 and 3.1 μM, respectively.
TN5201 Uncarinic acid E 277751-61-8 98%
Uncarinic acid E
Uncarinic acid E has anti-cancer activity, it induces apoptosis in HepG2 cells via accumulation of p53, alters the Bax/Bcl-2 ratio, and activates caspases, resul...
TN2149 Reynosin 28254-53-7 98%
Reynosin
Reynosin has hepatoprotective, and anti-inflammatory effects, it has protective effect against dopamine-induced neuronal cell death, which may be due to the reci...
T14213 Tapotoclax 1883727-34-1 98%
Tapotoclax
AMG-176 is a MCL-1 inhibitor (Ki: 0.13 nM).
TN2106 Protodeltonin 94992-08-2 98%
Protodeltonin
Protodeltonin may have anti-thrombotic activity by both improving the anticoagulation activity and inhibiting platelet aggregation action. Protodeltonin can inhi...
TN1617 Ergosta-4,6,8(14),22-tetraen-3-one 19254-69-4 98%
Ergosta-4,6,8(14),22-tetraen-3-one
Ergosta-4,6,8(14),22-tetraen-3-one has cytotoxic activity against human gastric cancer cell, it can induce G2/M cell cycle arrest and apoptosis in human hepatoce...
TN3618 Cedrin 75513-81-4 98%
Cedrin
Cedrin has protective effects on PC12 cells against the neurotoxicity induced by amyloid β1-42, the protective effect is related to the inhibition of oxidative s...
TN4341 IVHD-valtrate 28325-56-6 98%
IVHD-valtrate
VHD-valtrate has anticancer effects against human ovarian cancer cells in vitro and in vivo, it is a potential therapeutic agent for ovarian cancer, providing a ...
TN5100 Taspine 602-07-3 98%
Taspine
Taspine shows antitumor activity by modulating the EGFR signaling pathway of Erk1/2 and Akt in vitro and in vivo, it can inhibit growth and induce apoptosis of H...
T11975 PROTAC Mcl1 degrader-1 2163793-38-0 98%
PROTAC Mcl1 degrader-1
PROTAC Mcl1 degrader-1 induces the ubiquitination and proteasomal degradation of Mcl-1 by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide t...
TN2002 Obovatol 83864-78-2 98%
Obovatol
Obovatol has antioxidant, neuroprotective, antiinflammatory, antithrombotic and antitumour effects, it is a potent NF-κB inhibitors for Alzheimer's disease treat...
TN2691 2',3'-Dehydrosalannol 97411-50-2 98%
2',3'-Dehydrosalannol
2',3'-Dehydrosalannol possesses antifeedant activity against Spodptera litura. It shows anticancer effects on triple-negative breast cancer(TNBC), it inhibits ca...
TN1093 Ginsenoside F4 181225-33-2 98%
Ginsenoside F4
Ginsenoside F4 has inhibitory effect on human lymphocytoma JK cell by inducing its apoptosis, the mechanism is related to the mitochondrial dysfunction and the i...
TN1532 Crenulatin 63026-02-8 98%
Crenulatin
Crenulatin has dual- direction effects on apoptosis of cerebral microvascular endothelial cells, inhibitive effect in 25 mg/L and stimulative effect in 100 mg/L ...
TN2775 2-Methoxystypandrone 85122-21-0 98%
2-Methoxystypandrone
2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the inflamm...
TN4604 Myricanone 32492-74-3 98%
Myricanone
Myricanone has antioxidant, and anticancer activities, it has apoptosis-promoting ability by triggering caspase activation, and suppression of cell proliferation...
Scutebarbatine A
TN2191
Scutebarbatine A shows significant antitumor effects on A549 cells in vivo and in vitro via mitochondria-mediated apoptosis by up-regulating expressions of caspa...
Pteropodine
TN2116
Pteropodine acts as a positive modulator of muscarinic M(1) and 5-HT(2) receptors. Pteropodine shows antigenotoxic, antioxidant and lymphocyte induction effects,...
Liriodenine
TN1875
Liriodenine is a potent inhibitor of topoisomerase II (EC 5.99.1.3) both in vivo and in vitro, it has antitumor, antibacterial and antifungal activities, it can ...
Metaldehyde
T16042
Metaldehyde is used for snails and other gastropods pesticide against.
Mcl1-IN-12
T11974
Mcl1-IN-12 has anti-tumor activity.It is a selective Mcl-1 inhibitor, less potent at Bcl-2, with Kis of 0.29 and 3.1 μM, respectively.
Uncarinic acid E
TN5201
Uncarinic acid E has anti-cancer activity, it induces apoptosis in HepG2 cells via accumulation of p53, alters the Bax/Bcl-2 ratio, and activates caspases, resul...
Reynosin
TN2149
Reynosin has hepatoprotective, and anti-inflammatory effects, it has protective effect against dopamine-induced neuronal cell death, which may be due to the reci...
Tapotoclax
T14213
AMG-176 is a MCL-1 inhibitor (Ki: 0.13 nM).
Protodeltonin
TN2106
Protodeltonin may have anti-thrombotic activity by both improving the anticoagulation activity and inhibiting platelet aggregation action. Protodeltonin can inhi...
Ergosta-4,6,8(14),22-tetraen-3-one
TN1617
Ergosta-4,6,8(14),22-tetraen-3-one has cytotoxic activity against human gastric cancer cell, it can induce G2/M cell cycle arrest and apoptosis in human hepatoce...
Cedrin
TN3618
Cedrin has protective effects on PC12 cells against the neurotoxicity induced by amyloid β1-42, the protective effect is related to the inhibition of oxidative s...
IVHD-valtrate
TN4341
VHD-valtrate has anticancer effects against human ovarian cancer cells in vitro and in vivo, it is a potential therapeutic agent for ovarian cancer, providing a ...
Taspine
TN5100
Taspine shows antitumor activity by modulating the EGFR signaling pathway of Erk1/2 and Akt in vitro and in vivo, it can inhibit growth and induce apoptosis of H...
PROTAC Mcl1 degrader-1
T11975
PROTAC Mcl1 degrader-1 induces the ubiquitination and proteasomal degradation of Mcl-1 by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide t...
Obovatol
TN2002
Obovatol has antioxidant, neuroprotective, antiinflammatory, antithrombotic and antitumour effects, it is a potent NF-κB inhibitors for Alzheimer's disease treat...
2',3'-Dehydrosalannol
TN2691
2',3'-Dehydrosalannol possesses antifeedant activity against Spodptera litura. It shows anticancer effects on triple-negative breast cancer(TNBC), it inhibits ca...
Ginsenoside F4
TN1093
Ginsenoside F4 has inhibitory effect on human lymphocytoma JK cell by inducing its apoptosis, the mechanism is related to the mitochondrial dysfunction and the i...
Crenulatin
TN1532
Crenulatin has dual- direction effects on apoptosis of cerebral microvascular endothelial cells, inhibitive effect in 25 mg/L and stimulative effect in 100 mg/L ...
2-Methoxystypandrone
TN2775
2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the inflamm...
Myricanone
TN4604
Myricanone has antioxidant, and anticancer activities, it has apoptosis-promoting ability by triggering caspase activation, and suppression of cell proliferation...
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TargetMol