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Akt

Protein kinase B (PKB), also known as Akt, is a serine/threonine-specific protein kinase that plays a key role in multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription, and cell migration.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
TN4038 Eupatolide 6750-25-0 98%
Eupatolide
Eupatolide is isolated from the flowers of Inula japonica with anti-inflammatory activity. Eupatolide can be used in studies about TRAIL resistance in breast can...
T10274 AKT-IN-2 1295514-91-8 98%
AKT-IN-2
AKT-IN-2 is a selective, and orally bioavailable AKT inhibitor (IC50: 5 nM for AKT1).
T11743 Kanosamine hydrochloride 57649-10-2 98%
Kanosamine hydrochloride
Kanosamine hydrochloride is an antibiotic which inhibits the growth of plant-pathogenic oomycetes, certain fungi and a few bacterial species. Kanosamine inhibits...
TN4263 Isoangustone A 129280-34-8 98%
Isoangustone A
Isoangustone A has antitumor activity, it can induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells, it inhibits cell proliferation ...
TN4390 Kihadanin B 73793-68-7 98%
Kihadanin B
Kihadanin B can repress the adipogenesis by decreasing lipid accumulation through the suppression of the Akt-FOXO1-PPARγ axis in 3T3-L1 adipocytes.
TN1376 α-Solanine 20562-02-1 98%
α-Solanine
Alpha-Solanine alters antioxidative enzyme activities and MDA and PCO concentrations and GST activity in fat body and midgut.
TN1235 3,4,5-Tricaffeoylquinic acid 86632-03-3 98%
3,4,5-Tricaffeoylquinic acid
3,4,5-Tricaffeoylquinic acid may attenuate the TNF-α±- and LPS-stimulated production of inflammatory mediators in keratinocytes by suppressing the Toll-like rece...
TN3691 Communic acid 2761-77-5 98%
Communic acid
Communic acid has antibacterial activity, including against mycobacterial. trans-Communic acid has potential to be utilized as anti-wrinkling agents and cosmetic...
TN3525 Boehmenan 57296-22-7 98%
Boehmenan
(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in ...
TN3219 7,8-Didehydrocimigenol 150972-72-8 98%
7,8-Didehydrocimigenol
7,8-Didehydrocimigenol can be used for the treatment of cardiovascular disorders such as atherosclerosis. It upregulates PPAR-γ in EC inhibits NF-kB activity of ...
TN1458 Buddlejasaponin IV 139523-30-1 98%
Buddlejasaponin IV
Buddlejasaponin IV has analgesic and anti-inflammatory effects, the inhibitions of the expressions of iNOS, COX-2, TNF-alpha, IL-1beta and IL-6 by blocking NF-ka...
TN4244 Icariside B1 109062-00-2 98%
Icariside B1
Icariside B1 shows inhibitory effects on LPS-induced NO production in RAW264.7 cells.
TN1889 Lupalbigenin 76754-24-0 98%
Lupalbigenin
Lupalbigenin sensitizes detachment-induced cell death in human lung cancer cell through down-regulation of pro-survival proteins.
TN4506 (+)-Matairesinol 148409-36-3 98%
(+)-Matairesinol
(+)-Matairesinol exhibits immunomodulatory activity; it also shows inhibition of the discoloration of yellowtail dark muscle.
TN3139 5α-Hydroxycostic acid 132185-83-2 98%
5α-Hydroxycostic acid
5alpha-Hydroxycostic acid possesses anti-angiogenic ability by interfering the VEGF- and Ang2-related pathways, and it may be a good drug candidate.
T15056 DB07107 552332-71-5 98%
DB07107
DB07107 is a potent inhibitor of drug resistant T315I mutant Bcr-Abl tyrosine kinase and a potent Akt1 inhibitor (IC50: 360 nM).
T2S0606 Bakkenolide A 19906-72-0 98%
Bakkenolide A
Bakkenolide A has antifeedant and growth inhibitory effects on neonate variegated cutworms, it inhibits leukemia by regulation of HDAC3 and PI3K/Akt-related sign...
TMA1743 Ergosterol peroxide 2061-64-5 98%
Ergosterol peroxide
Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Fox...
TN2328 Zeylenone 193410-84-3 98%
Zeylenone
Zeylenone, a cyclohexene oxide from Uvaria grandiflora, has antitumour and antiproliferative activity, inhibiting cervical cancer cell proliferation and inducing...
T75078 Antitumor agent-86 2907704-65-6 98%
Antitumor agent-86
Antitumor agent-86 (compound 5a) demonstrates efficacy against MCF-7 breast cancer cells, manifesting an inhibitory concentration (IC 50) of 2.62 µM. It promotes...
Eupatolide
TN4038
Eupatolide is isolated from the flowers of Inula japonica with anti-inflammatory activity. Eupatolide can be used in studies about TRAIL resistance in breast can...
AKT-IN-2
T10274
AKT-IN-2 is a selective, and orally bioavailable AKT inhibitor (IC50: 5 nM for AKT1).
Kanosamine hydrochloride
T11743
Kanosamine hydrochloride is an antibiotic which inhibits the growth of plant-pathogenic oomycetes, certain fungi and a few bacterial species. Kanosamine inhibits...
Isoangustone A
TN4263
Isoangustone A has antitumor activity, it can induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells, it inhibits cell proliferation ...
Kihadanin B
TN4390
Kihadanin B can repress the adipogenesis by decreasing lipid accumulation through the suppression of the Akt-FOXO1-PPARγ axis in 3T3-L1 adipocytes.
α-Solanine
TN1376
Alpha-Solanine alters antioxidative enzyme activities and MDA and PCO concentrations and GST activity in fat body and midgut.
3,4,5-Tricaffeoylquinic acid
TN1235
3,4,5-Tricaffeoylquinic acid may attenuate the TNF-α±- and LPS-stimulated production of inflammatory mediators in keratinocytes by suppressing the Toll-like rece...
Communic acid
TN3691
Communic acid has antibacterial activity, including against mycobacterial. trans-Communic acid has potential to be utilized as anti-wrinkling agents and cosmetic...
Boehmenan
TN3525
(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in ...
7,8-Didehydrocimigenol
TN3219
7,8-Didehydrocimigenol can be used for the treatment of cardiovascular disorders such as atherosclerosis. It upregulates PPAR-γ in EC inhibits NF-kB activity of ...
Buddlejasaponin IV
TN1458
Buddlejasaponin IV has analgesic and anti-inflammatory effects, the inhibitions of the expressions of iNOS, COX-2, TNF-alpha, IL-1beta and IL-6 by blocking NF-ka...
Icariside B1
TN4244
Icariside B1 shows inhibitory effects on LPS-induced NO production in RAW264.7 cells.
Lupalbigenin
TN1889
Lupalbigenin sensitizes detachment-induced cell death in human lung cancer cell through down-regulation of pro-survival proteins.
(+)-Matairesinol
TN4506
(+)-Matairesinol exhibits immunomodulatory activity; it also shows inhibition of the discoloration of yellowtail dark muscle.
5α-Hydroxycostic acid
TN3139
5alpha-Hydroxycostic acid possesses anti-angiogenic ability by interfering the VEGF- and Ang2-related pathways, and it may be a good drug candidate.
DB07107
T15056
DB07107 is a potent inhibitor of drug resistant T315I mutant Bcr-Abl tyrosine kinase and a potent Akt1 inhibitor (IC50: 360 nM).
Bakkenolide A
T2S0606
Bakkenolide A has antifeedant and growth inhibitory effects on neonate variegated cutworms, it inhibits leukemia by regulation of HDAC3 and PI3K/Akt-related sign...
Ergosterol peroxide
TMA1743
Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Fox...
Zeylenone
TN2328
Zeylenone, a cyclohexene oxide from Uvaria grandiflora, has antitumour and antiproliferative activity, inhibiting cervical cancer cell proliferation and inducing...
Antitumor agent-86
T75078
Antitumor agent-86 (compound 5a) demonstrates efficacy against MCF-7 breast cancer cells, manifesting an inhibitory concentration (IC 50) of 2.62 µM. It promotes...
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TargetMol