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Siramesine

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  • Inhibitors & Agonists
    3
    TargetMol | Activity
Siramesine
T4620147817-50-3
Siramesine (Lu 28-179)(Lu 28-179) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of cancer cells and to exhibit a potent anticancer activity in vivo.lysosome-destabilizing agent siramesine can induce rapid cell death in a number of cell lines at concentrations above 20 μM. In HaCaT cells, cell death was accompanied by caspase activation, rapid loss of mitochondrial membrane potential (MMP), cytochrome c release, cardiolipin peroxidation and typical apoptotic morphology, whereas in U-87MG cells most apoptotic hallmarks were not notable, although MMP was rapidly lost
  • $207
1-2 weeks
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QTY
TargetMol | Citations Cited
Siramesine hydrochloride
T1885224177-60-0
Siramesine hydrochloride (Lu 28-179 hydrochloride) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of Y cells and to exhibit a potent anticancer activity in vivo.
  • $33
In Stock
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TargetMol | Inhibitor Sale
Siramesine Fumarate
T1885L163630-79-3
Siramesine Fumarate, a sigma receptor agonist, is used potentially for the treatment of generalized anxiety disorder.
  • $93
35 days
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