Search Result

Search Results for " rna-polymerases "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T8647	BCH001		DNA/RNA Synthesis
	BCH001 is a specific small-molecule inhibitor of PAPD5.		DNA/RNA Synthesis
T5539	GS-443902		Nucleoside Antimetabolite/Analog , HCV Protease , SARS-CoV , DNA/RNA Synthesis , RSV , Drug Metabolite
	GS-441524 was shown to be a safe and effective treatment for feline infectious peritonitis (FIP). The optimum dosage was found to be 4.0 mg/kg SC q24h for at least 12 weeks
T9618	HeE1-2Tyr		SARS-CoV
	HeE1-2Tyr, a pyridobenzothiazole compound, is a flavivirus RNA dependent RNA polymerases (RdRp) inhibitor. It significantly inhibits West Nile, Dengue and SARS-CoV-2 RdRps (IC50 of 27.6 µM) activity in vitro.		SARS-CoV
T16945	Streptolydigin	Portamycin	Antibacterial
	Streptolydigin inhibits RNA synthesis by binding to RNA polymerase and does not inhibit eukaryotic RNA polymerases. Streptolydigin is a 3-acetyltetramic acid antibiotic and a potent bacterial RNA polymerase inhibitor (Ki...		Antibacterial
T38761	GS-443902 trisodium	GS-441524triphosphatetrisodium,Remdesivirmetabolitetrisodium
	GS-443902 trisodium (GS-441524 triphosphate trisodium), the active triphosphate metabolite of Remdesivir (GS-5734), serves as a potent inhibitor of viral RNA-dependent RNA-polymerases (RdRp), displaying inhibitory concen...
T40359	Thio-ITP	6-Thio-ITP,Thio-ITP,6-Mercaptopurine-riboside-5'-triphosphate,6-Thioinosine 5′-triphosphate
	Thio-ITP, also known as 6-Thioinosine 5'-triphosphate, is a competitive inhibitor of RNA polymerase activity. It exhibits a strong apparent affinity towards the polymerases, with Ki values of 40.9 μM for RNA polymerase I...
T35657	3'-Deoxyuridine-5'-triphosphate
	3'-Deoxyuridine-5'-triphosphate (3'-dUTP) is a nucleotide analogue that not only inhibits DNA-dependent RNA polymerases I and II, but also competitively and strongly inhibits the incorporation of UTP into RNA, exhibiting...
T35658	3'-Deoxyuridine-5'-triphosphate trisodium
	3'-Deoxyuridine-5'-triphosphate trisodium (3'-dUTP trisodium) is a nucleotide analogue that suppresses DNA-dependent RNA polymerases I and II activity. It competitively obstructs the inclusion of UTP into RNA, demonstrat...
T80760	XSJ2-46		Influenza Virus
	XSJ2-46, a 5'-amino NI analog, is an antiviral agent possessing anti-Zika virus properties and demonstrates reasonable inhibition of RNA-dependent RNA polymerases (RdRp), with an IC50 of 8.78 μM [1].		Influenza Virus
T38297	Ribavirin-13C5	Ribavirin-13C5
	Ribavirin-13C5is intended for use as an internal standard for the quantification of ribavirin by GC- or LC-MS. Ribavirin is an antiviral guanosine nucleoside analog.1,2Upon entry into cells, ribavirin is metabolized to a...

Compounds

BCH001

T8647

Synonym:

Target: DNA/RNA Synthesis

GS-443902

T5539

Synonym:

Target: Nucleoside Antimetabolite/Analog, HCV Protease, SARS-CoV, DNA/RNA Synthesis, RSV, Drug Metabolite

Target: Antibacterial

GS-443902 trisodium

T38761

Synonym: GS-441524triphosphatetrisodium,Remdesivirmetabolitetrisodium

Target:

Thio-ITP

T40359

Synonym: 6-Thio-ITP,Thio-ITP,6-Mercaptopurine-riboside-5'-triphosphate,6-Thioinosine 5′-triphosphate

Target:

3'-Deoxyuridine-5'-triphosphate

T35657

Synonym:

Target:

3'-Deoxyuridine-5'-triphosphate trisodium

Target: Influenza Virus

Ribavirin-13C5

T38297

Synonym: Ribavirin-13C5

Target:

Cat No.	Product Name	Synonyms	Targets
T5288	Cytidine-5'-triphosphate disodium	CTP,Cytidine 5'-triphosphate (disodium salt)	Others , Endogenous Metabolite
	Cytidine-5'-triphosphate disodium (CTP) is a pyrimidine nucleoside triphosphate that is involved in a variety of biochemical reactions. Cytidine-5'-triphosphate disodium is used in the synthesis of RNA by RNA polymerases...		Others , Endogenous Metabolite
T7004	Tubercidin	Sparsomycin A,7-Deazaadenosine	Influenza Virus , DNA/RNA Synthesis , Antibacterial , Antibiotic
	Tubercidin (Sparsomycin A), an adenosine analogue, is a nucleoside antibiotic. It is incorporated into DNA and inhibits polymerases, thereby inhibiting DNA replication and RNA and protein synthesis. This agent also exhib...
T4010	Juglone	5-Hydroxy-1,4-naphthoquinone,Regianin	DNA/RNA Synthesis , Antibacterial
	Juglone (Regianin) is a natural naphthoquinone found in the black walnut (J. nigra) and other plants in the Juglandaceae family. Juglone also irreversibly inhibits peptidyl-prolyl cis/trans isomerases of the parvulin fam...		DNA/RNA Synthesis , Antibacterial

Natural Products

Cytidine-5'-triphosphate disodium

T5288

Synonym: CTP,Cytidine 5'-triphosphate (disodium salt)

Target: Others, Endogenous Metabolite

Tubercidin

T7004

Synonym: Sparsomycin A,7-Deazaadenosine

Target: Influenza Virus, DNA/RNA Synthesis, Antibacterial, Antibiotic

Juglone

T4010

Synonym: 5-Hydroxy-1,4-naphthoquinone,Regianin

Target: DNA/RNA Synthesis, Antibacterial

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPH-02380	RPB5 Protein, Kluyveromyces marxianus, Recombinant (His)	Kluyveromyces marxianus	E. coli
	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precurs...

RPB5 Protein, Kluyveromyces marxianus, Recombinant (His)

TMPH-02380

Species: Kluyveromyces marxianus

Expression System: E. coli