mTOR

The mammalian target of rapamycin (mTOR), sometimes also referred to as the mechanistic target of rapamycin and FK506-binding protein 12-rapamycin-associated protein 1 (FRAP1), is a kinase that in humans is encoded by the MTOR gene. mTOR is a member of the phosphatidylinositol 3-kinase-related kinase family of protein kinases.mTOR links with other proteins and serves as a core component of two distinct protein complexes, mTOR complex 1 and mTOR complex 2, which regulate different cellular processes. In particular, as a core component of both complexes, mTOR functions as a serine/threonine protein kinase that regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis, autophagy, and transcription. As a core component of mTORC2, mTOR also functions as a tyrosine protein kinase that promotes the activation of insulin receptors and insulin-like growth factor 1 receptors. mTORC2 has also been implicated in the control and maintenance of the actin cytoskeleton.

Cat. No.	Product name	CAS No.	Purity
T1958	AZ20	1233339-22-4	98.02%
T1958	AZ20 is an effective and specific inhibitor of ATR kinase (IC50: 5 nM, in a cell-free assay), 8-fold selectivity over mTOR.
T2357	GSK1059615	958852-01-2	98%
T2357	GSK1059615 has been used in trials studying the treatment of Lymphoma, Solid Tumours, Endometrial Cancer, Solid Tumor Cancer, and Metastatic Breast Cancer.
T3705	GDC0084	1382979-44-3	98%
T3705	GDC0084 (RG7666) is a PI3K inhibitor with potential antineoplastic activity. GDC0084 (RG7666) specifically inhibits PI3K in the PI3K/AKT kinase (or protein kinas...
T2083	PI-3065	955977-50-1	98%
T2083	PI-3065 is a novel potent and selective PI3K p110δ inhibitor.
T7166	GNE-493	1033735-94-2	98%
T7166	GNE-493 is potent, selective, and orally available PI3K and mTOR inhibitor with potential anticancer activity.IC50s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM for ...
T6820	D-α-Hydroxyglutaric acid disodium	103404-90-6	98%
T6820	D-α-Hydroxyglutaric acid disodium (Disodium (R)-2-Hydroxyglutarate) is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases with Ki of 0.628 mM.
T1859	AZD-8055	1009298-09-2	98%
T1859	AZD8055 is an ATP-competitive mTOR inhibitor (IC50: 0.8 nM in MDA-MB-468 cells). It is ~1,000-fold selective for mTOR over all PI3K isoforms.
T6319	OSI-027	936890-98-1	98%
T6319	OSI-027 (ASP4786) is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM, and more than 100-fold selectivity observed for mTO...
T6334	Ridaforolimus	572924-54-0	98%
T6334	Ridaforolimus (AP23573) is a small molecule and non-prodrug analogue of the lipophilic macrolide antibiotic rapamycin with potential antitumor activity. Ridaforo...
T1961	Vistusertib	1009298-59-2	97.94%
T1961	Vistusertib (AZD2014) is an orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity.
T9314	CC214-1	1021920-32-0	97.87%
T9314	CC214-1 is an mTOR inhibitor with potential anticancer activity, inhibits protein translation, and induces autophagy. CC214-1 is an in vitro tool compound for ex...
T2974	Cyclovirobuxine D	860-79-7	97.78%
T2974	Cyclovirobuxine D (Bebuxine) is extracted from Buxus microphylla.
T1908	MHY1485	326914-06-1	97.74%
T1908	MHY1485 is a mTOR activator. It inhibits the autophagic process by inhibition of fusion between autophagosomes and lysosomes, leading to the accumulation of LC3I...
T6354	(+)-Usnic acid	7562-61-0	97.61%
T6354	(+)-Usnic acid (D-Usnic Acid) is a naturally occurring dibenzofuran derivative found in several lichen species.
T4423	LY 303511 hydrochloride	2070014-90-1	97.44%
T4423	LY 303511 hydrochloride is a potent mTOR inhibitor
TN1405	Arnicolide D	34532-68-8	96.66%
TN1405	Arnicolide D is a sesquiterpene lactone. Arnicolide D isolates from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling path...
T14033	3BDO	890405-51-3	96.00%
T14033	3BDO is an activator of mTOR. It can also inhibit autophagy..
T6072L	BGT226	915020-55-2	95.74%
T6072L	BGT226 (NVP-BGT226) is a novel dual PI3K / mTOR inhibitor, it acts on PI3K α/β/γ with IC50 of 4 nM / 63 nM / 38 nM, respectively.
T3541	CC-115	1228013-15-7	86.79%
T3541	CC-115 is a inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM).
T4199	Desmethyl-VS-5584	1246535-95-4	100%
T4199	Desmethyl-VS-5584 is a dimethyl analog of VS-5584, which is a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer.