T1920 |
Capivasertib
|
1143532-39-1
|
99.29%
|
|
Capivasertib (AZD5363) is a broad-spectrum AKT inhibitor with inhibitory activity against Akt1, Akt2, and Akt3 (IC50=3/7/7 nM) with oral activity. Capivasertib h...
|
T2717 |
Salidroside
|
10338-51-9
|
99.25%
|
|
Salidroside (Rhodioloside) is a bioactive phenolic glycoside compound isolated from Rhodiola crenulata. It is a prolyl endopeptidase Inhibitor.
|
T28652 |
S6K1-IN-DG2
|
871340-88-4
|
99.25%
|
|
S6K1-IN-DG2(S6K1InhibitorDG2) is a potent p70S6K inhibitor with an IC50 value of less than 100 nM.
|
T9310 |
MTOR inhibitor 13
|
1144075-44-4
|
99.24%
|
|
mTOR inhibitor 13 is a selective mTOR inhibitor with IC50 of 0.29nM and 119nM for mTOR and PI3Kα, respectively.
|
T2414 |
Torkinib
|
1092351-67-1
|
99.23%
|
|
Torkinib (PP 242) (PP 242) is a selective and ATP-competitive mTOR inhibitor (IC50: 8 nM). It also inhibits mTORC1/2 (IC50s: 30/58 nM).
|
T8884 |
HSMG-1 inhibitor 11j
|
1402452-15-6
|
99.22%
|
|
hSMG-1 inhibitor 11j is a pyrimidine derivative. hSMG-1 inhibitor 11j is a potent and selective inhibitor of hSMG-1, IC50 = 0.11 nM. hSMG-1 inhibitor 11j exhibit...
|
T6557 |
KU-0060648
|
881375-00-4
|
99.21%
|
|
KU-0060648 is a dual inhibitor of DNA-PK and PI3Kα, PI3Kβ, PI3Kδ with IC50 of 8.6 nM and 4 nM, 0.5 nM, 0.1 nM respectively, less inhibition of PI3Kγ with IC50 of...
|
T2415 |
PP121
|
1092788-83-4
|
99.19%
|
|
PP-121 is a multi-targeted inhibitor of PDGFR (IC50: 2 nM), Hck (IC50: 8 nM), mTOR (IC50: 10 nM), VEGFR2(IC50: 12 nM), Src (IC50: 14 nM) and Abl (IC50: 18 nM) , ...
|
T1861 |
Omipalisib
|
1086062-66-9
|
99.16%
|
|
Omipalisib (GSK2126458) is a small-molecule pyridylsulfonamide inhibitor of phosphatidylinositol 3-kinase (PI3K) with potential antineoplastic activity.
|
T25399 |
ETP-45658
|
1198357-79-7
|
99.13%
|
|
ETP-45658 (ETP45658) is a PI 3-kinase inhibitor (IC50 values are 22, 30, 129 and 710 nM for PI 3-Kα, PI 3-Kδ, PI 3-Kβ and PI 3-Kγ respectively). Also inhibits DN...
|
T9156 |
CDC25B-IN-2
|
134271-74-2
|
99.12%
|
|
BIA is an inhibitor of the interaction between TMBIM6 and mTORC2, which ultimately blocks AKT activation and cancer progression.
|
T16355 |
NSC781406
|
1676893-24-5
|
99.08%
|
|
NSC781406 is a highly effective inhibitor of PI3K and mTOR (IC50: 2 nM for PI3Kα).
|
T14998 |
Copanlisib dihydrochloride
|
1402152-13-9
|
99.05%
|
|
Copanlisib dihydrochloride (BAY 80-6946 dihydrochloride) is an ATP-competitive pan-class I PI3K inhibitor (IC50s: 0.5 nM, 0.7 nM, 3.7 nM and 6.4 nM for PI3Kα, PI...
|
T8569 |
DMH-25
|
1685280-21-0
|
99.05%
|
|
DMH25 is a novel covalent and potent inhibitor of mTOR and shows in vivo antitumor activity against triple-negative breast cancer cells.
|
T2706 |
Palomid 529
|
914913-88-5
|
99.03%
|
|
Palomid 529 (SG 00529) has been used in trials studying the treatment of Age-Related Macular Degeneration.
|
T6510 |
GDC-0349
|
1207360-89-1
|
98.98%
|
|
GDC-0349 (RG-7603) is a potent and selective ATP-competitive inhibitor of mTOR with Ki of 3.8 nM, 790-fold inhibitory effect against PI3Kα and other 266 kinases....
|
T6732 |
WYE-687
|
1062161-90-3
|
98.98%
|
|
WYE-687 is an ATP-competitive and selective inhibitor of mTOR with IC50 of 7 nM; blocks mTORC1/pS6K(T389) and mTORC2/P-AKT(S473) but no effect observed on P-AKT(...
|
T12270 |
NV-5138
|
2095886-80-7
|
98.97%
|
|
NV-5138 is a selective and orally active activator of brain mTORC1, with antidepressant effects.
|
T67702 |
MTOR inhibitor 9d
|
1144075-38-6
|
98.90%
|
|
mTOR inhibitor 9d is a dual inhibitor of the protein kinases mTOR and PI3K with an mTOR IC50 value of 0.31 nm, and can be used for the treatment of leukemia, ski...
|
T11728 |
JR-AB2-011
|
2411853-34-2
|
98.87%
|
|
JR-AB2-011 is a selective mTORC2 inhibitor with an IC 50 value of 0.36 μM. JR-AB2-011 inhibits mTORC2 activity by blocking Rictor-mTOR association ( K i : 0.19 μ...
|