T15658 |
KH7
|
330676-02-3
|
99.56%
|
|
KH7 is a soluble inhibitor of adenylyl cyclase (sAC)-specific. It has IC50s of 3-10 μM toward both recombinant purified human sACt protein and heterologously exp...
|
T6536 |
HJC0350
|
885434-70-8
|
99.53%
|
|
HJC0350 is an effective and specific EPAC2 inhibitor (IC50: 0.3 μM), and no inhibition of Epac1.
|
TN3466 |
Atherosperminine
|
5531-98-6
|
99.4%
|
|
Atherosperminine shows cholinesterase inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Atherosperminine shows strong ant...
|
TN1620 |
Eriocalyxin B
|
84745-95-9
|
99.35%
|
|
Eriocalyxin B induces apoptosis and cell cycle arrest in pancreatic adenocarcinoma cells through caspase- and p53-dependent pathways, should be considered a cand...
|
T0830 |
Bithionol
|
97-18-7
|
99.27%
|
|
Bithionol (Actamer), formerly marketed as an active ingredient in various topical drug products, was shown to be a potent photosensitizer with the potential to c...
|
T67965 |
Torbafylline
|
105102-21-4
|
99.21%
|
|
Torbafylline, a xanthine derivative, is a phosphodiesterase (PDE) inhibitor that attenuates burn-induced protein hydrolysis in rat skeletal muscle through activa...
|
T11234 |
ESI-08
|
301177-43-5
|
99.05%
|
|
ESI-08 is an effective antagonist of EPAC2 with an IC50 of 8.4 μM. ESI-08 selectively blocks cAMP-induced EPAC activation but not cAMP-mediated PKA activation.
|
T13983 |
0990CL
|
511514-03-7
|
98.86%
|
|
0990CL is an effective heterotrimer Gαi subunit specific inhibitor, which can interact with purified Go± in GDP-bound state, and can block α2AR mediated cAMP reg...
|
T2244 |
ESI-09
|
263707-16-0
|
98.48%
|
|
ESI-09 is a new-typel noncyclic nucleotide EPAC antagonist.The IC50 values of ESI-09 for EPAC1 and EPAC2 is 3.2 and 1.4 μM, respectively.
|
TN1334 |
7-Methoxyrosmanol
|
113085-62-4
|
98.4%
|
|
7-Methoxyrosmanol (7-O-Methylrosmanol) can effectively suppress FSK-induced luciferase expression under the control of the CRE, PEPCK-C and G6Pase gene promoters...
|
T15247 |
ESI-05
|
5184-64-5
|
98%
|
|
ESI-05 (NSC-116966) is a specific EPAC2 (exchange protein directly activated by cAMP 2) antagonist (IC50: 0.4 μM). ESI-05 inhibits cAMP-mediated activation of EP...
|
T64355 |
TDI-10229
|
2810887-45-5
|
97.77%
|
|
TDI-10229 is a potent and orally available inhibitor of soluble adenylyl cyclase (sAC, ADCY10). TDI-10229 displays nanomolar inhibition of sAC in both biochemica...
|
T12616L |
CE3F4
|
143703-25-7
|
97.15%
|
|
CE3F4 is a selective antagonist of exchange protein directly activated by cAMP (Epac1; IC50s of 10.7 μM and 66 μM for Epac1 and Epac2(B), respectively).
|
T22466 |
Adenosine receptor A1 antagonist 5
|
85872-53-3
|
100%
|
|
Adenosine receptor A1 antagonist 5 acts as an adenosine antagonist, is an oxypurine, acts as an insecticide and pest control agent, and has an inhibitory effect ...
|
T24154 |
I942
|
868145-09-9
|
98%
|
|
I942 is a novel, selective ACyclic nucleotide (NCN) EPAC1 agonist that activates exchange proteins to regulate inflammatory gene expression in human umbilical bl...
|
T61562 |
CB1R Allosteric modulator 3
|
2633686-36-7
|
98%
|
|
CB1R Allosteric modulator 3 is a potent CB1R modulator.CB1R Allosteric modulator 3 inhibits cAMP and β-Arrestin, and can be used for the study of obesity and nic...
|
T11212 |
EPAC 5376753
|
302826-61-5
|
98%
|
|
EPAC 5376753 is an allosteric inhibitor of EPAC1 with an IC50 of 4 µM in Swiss 3T3 cells.
|
T40279 |
GLP-1R modulator L7-028
|
2648317-95-5
|
98%
|
|
GLP-1R modulator L7-028 is a variant modulator that enhances affinity for GLP-1 and cAMP signaling.
|