T9642 |
ZW4864 free base
|
2632259-92-6
|
99.54%
|
|
ZW4864 (free base) is an orally active and selective β catenin/B-Cell lymphoma 9 protein protein interaction ( β catenin/BCL9 PPI ) inhibitor. ZW4864 (free base)...
|
T67884 |
β-catenin modulator IIa-661
|
1015859-04-7
|
99.53%
|
|
β-catenin modulator IIa-661 is a small molecule inhibitor of the Wnt pathway with antitumour activity.
|
T63427 |
NRX-103094
|
2763260-36-0
|
99.50%
|
|
NRX-103094 is a potent enhancer of the interaction of β-catenin with the homologous E3 ligase SCFβ-TrCP, which enhances the affinity of pSer33/Ser37 β-catenin fo...
|
T6989 |
SKL2001
|
909089-13-0
|
99.5%
|
|
SKL2001, an agonist of the Wnt/β-catenin pathway, can disrupt the Axin/β-catenin interaction.
|
T2413 |
FH535
|
108409-83-2
|
99.5%
|
|
FH535, a Wnt/β-catenin signaling and PPAR inhibitor, exhibits anti-tumor activities.
|
TL0008 |
Gigantol
|
67884-30-4
|
99.48%
|
|
Gigantol is a novel inhibitor of the Wnt/β-catenin pathway. It inhibits Wnt/β-catenin signaling through downregulation of phosphorylated LRP6 and cytosolic β-cat...
|
T4011 |
NCB-0846
|
1792999-26-8
|
99.46%
|
|
NCB-0846 is an orally active TNIK inhibitor (IC50: 21 nM).
|
T2933 |
Wogonin
|
632-85-9
|
99.43%
|
|
Wogonin (Vogonin) is a cell-permeable and orally available flavonoid that displays anti-inflammatory and anticancer properties.
|
T3S0153 |
Xanthatin
|
26791-73-1
|
99.39%
|
|
1. Xanthatin has cytotoxic activity. 2. Xanthatin has antibacterial and antifungal activies against MRSA. 3. Xanthatin may have therapeutic potential against NSC...
|
T24076 |
FzM1
|
1680196-54-6
|
99.37%
|
|
FzM1 is a negative allosteric modulator (NAM) of Frizzled receptor FZD4. FzM1 reduces WNT5A-dependent WNT responsive element (WRE) activity (log EC50inh=−6.2). F...
|
T14907 |
CCT251545
|
1661839-45-7
|
99.37%
|
|
CCT251545 is an potent and oral-bioavailable WNT signaling inhibitor(IC50 of 5 nM in 7dF3 cells).
|
T5S0754 |
Isoquercetin
|
482-35-9
|
99.29%
|
|
1. Isoquercetin (3-Glucosylquercetin) is a potential stimulator of bone mineralization used for prophylaxis of osteoporotic disorders. 2. Isoquercetin may be as ...
|
T1971 |
WAY-262611
|
1123231-07-1
|
99.27%
|
|
WAY-262611 is a wingless β-Catenin agonist.
|
T3803 |
Specnuezhenide
|
39011-92-2
|
99.12%
|
|
Specnuezhenide (Nuezhenide) significantly protects human neuroblastoma SH-SY5Y cells from 6-hydroxydopamine-induced neurotoxicity.Nuezhenide is the main inhibito...
|
T64414 |
PRI-724
|
1422253-38-0
|
99.11%
|
|
PRI-724 (C-82 prodrug) is a selective small-molecule inhibitor of β-catenin/CBP interaction.
|
TQ0215 |
Salinomycin sodium salt
|
55721-31-8
|
99.11%
|
|
Salinomycin sodium salt (Sodium salinomycin), an antibiotic potassium ionophore, is an effective inhibitor of Wnt/β-catenin signaling.
|
T9182 |
NRX-252262
|
2438637-61-5
|
99.10%
|
|
NRX-252262 is a potent enhancer of the interaction between β-Catenin, and its cognate E3 ligase, SCFβ-TrCP, induces mutant β-catenin degradation(EC50:3.8 nM)
|
T1878 |
XAV-939
|
284028-89-3
|
99.04%
|
|
XAV-939 (NVP-XAV939) shows the selective inhibition against Wnt/β-catenin-mediated transcription by tankyrase1/2 inhibition (IC50: 11/4 nM in cell-free assays).
|
T22657 |
Laduviglusib trihydrochloride
|
1782235-14-6
|
99.03%
|
|
Laduviglusib trihydrochloride (CT99021 trihydrochloride) is a selective glycogen synthase kinase 3 (GSK-3) inhibitor with IC50s of 10 nM and 6.7 nM for GSK-3α an...
|
T11190 |
EMT inhibitor-1
|
1638526-21-2
|
99%
|
|
EMT inhibitor-1 is an inhibitor of Hippo, Wnt signaling and TGF- macrophages (TGF-) with antitumor activity.
|