Home Tools
Log in
Cart

Wnt/beta-catenin

The Wnt signaling pathways are a group of signal transduction pathways which begin with proteins that pass signals into a cell through cell surface receptors. The name Wnt is a portmanteau created from the name Wingless and the name Int-1. Wnt signaling pathways use either nearby cell-cell communication (paracrine) or same-cell communication (autocrine). They are highly evolutionarily conserved in animals, which means they are similar across animal species from fruit flies to humans.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T9642 ZW4864 free base 2632259-92-6 99.54%
ZW4864 free base
ZW4864 (free base) is an orally active and selective β catenin/B-Cell lymphoma 9 protein protein interaction ( β catenin/BCL9 PPI ) inhibitor. ZW4864 (free base)...
T67884 β-catenin modulator IIa-661 1015859-04-7 99.53%
β-catenin modulator IIa-661
β-catenin modulator IIa-661 is a small molecule inhibitor of the Wnt pathway with antitumour activity.
T63427 NRX-103094 2763260-36-0 99.50%
NRX-103094
NRX-103094 is a potent enhancer of the interaction of β-catenin with the homologous E3 ligase SCFβ-TrCP, which enhances the affinity of pSer33/Ser37 β-catenin fo...
T6989 SKL2001 909089-13-0 99.5%
SKL2001
SKL2001, an agonist of the Wnt/β-catenin pathway, can disrupt the Axin/β-catenin interaction.
T2413 FH535 108409-83-2 99.5%
FH535
FH535, a Wnt/β-catenin signaling and PPAR inhibitor, exhibits anti-tumor activities.
TL0008 Gigantol 67884-30-4 99.48%
Gigantol
Gigantol is a novel inhibitor of the Wnt/β-catenin pathway. It inhibits Wnt/β-catenin signaling through downregulation of phosphorylated LRP6 and cytosolic β-cat...
T4011 NCB-0846 1792999-26-8 99.46%
NCB-0846
NCB-0846 is an orally active TNIK inhibitor (IC50: 21 nM).
T2933 Wogonin 632-85-9 99.43%
Wogonin
Wogonin (Vogonin) is a cell-permeable and orally available flavonoid that displays anti-inflammatory and anticancer properties.
T3S0153 Xanthatin 26791-73-1 99.39%
Xanthatin
1. Xanthatin has cytotoxic activity. 2. Xanthatin has antibacterial and antifungal activies against MRSA. 3. Xanthatin may have therapeutic potential against NSC...
T24076 FzM1 1680196-54-6 99.37%
FzM1
FzM1 is a negative allosteric modulator (NAM) of Frizzled receptor FZD4. FzM1 reduces WNT5A-dependent WNT responsive element (WRE) activity (log EC50inh=−6.2). F...
T14907 CCT251545 1661839-45-7 99.37%
CCT251545
CCT251545 is an potent and oral-bioavailable WNT signaling inhibitor(IC50 of 5 nM in 7dF3 cells).
T5S0754 Isoquercetin 482-35-9 99.29%
Isoquercetin
1. Isoquercetin (3-Glucosylquercetin) is a potential stimulator of bone mineralization used for prophylaxis of osteoporotic disorders. 2. Isoquercetin may be as ...
T1971 WAY-262611 1123231-07-1 99.27%
WAY-262611
WAY-262611 is a wingless β-Catenin agonist.
T3803 Specnuezhenide 39011-92-2 99.12%
Specnuezhenide
Specnuezhenide (Nuezhenide) significantly protects human neuroblastoma SH-SY5Y cells from 6-hydroxydopamine-induced neurotoxicity.Nuezhenide is the main inhibito...
T64414 PRI-724 1422253-38-0 99.11%
PRI-724
PRI-724 (C-82 prodrug) is a selective small-molecule inhibitor of β-catenin/CBP interaction.
TQ0215 Salinomycin sodium salt 55721-31-8 99.11%
Salinomycin sodium salt
Salinomycin sodium salt (Sodium salinomycin), an antibiotic potassium ionophore, is an effective inhibitor of Wnt/β-catenin signaling.
T9182 NRX-252262 2438637-61-5 99.10%
NRX-252262
NRX-252262 is a potent enhancer of the interaction between β-Catenin, and its cognate E3 ligase, SCFβ-TrCP, induces mutant β-catenin degradation(EC50:3.8 nM)
T1878 XAV-939 284028-89-3 99.04%
XAV-939
XAV-939 (NVP-XAV939) shows the selective inhibition against Wnt/β-catenin-mediated transcription by tankyrase1/2 inhibition (IC50: 11/4 nM in cell-free assays).
T22657 Laduviglusib trihydrochloride 1782235-14-6 99.03%
Laduviglusib trihydrochloride
Laduviglusib trihydrochloride (CT99021 trihydrochloride) is a selective glycogen synthase kinase 3 (GSK-3) inhibitor with IC50s of 10 nM and 6.7 nM for GSK-3α an...
T11190 EMT inhibitor-1 1638526-21-2 99%
EMT inhibitor-1
EMT inhibitor-1 is an inhibitor of Hippo, Wnt signaling and TGF- macrophages (TGF-) with antitumor activity.
ZW4864 free base
T9642
ZW4864 (free base) is an orally active and selective β catenin/B-Cell lymphoma 9 protein protein interaction ( β catenin/BCL9 PPI ) inhibitor. ZW4864 (free base)...
β-catenin modulator IIa-661
T67884
β-catenin modulator IIa-661 is a small molecule inhibitor of the Wnt pathway with antitumour activity.
NRX-103094
T63427
NRX-103094 is a potent enhancer of the interaction of β-catenin with the homologous E3 ligase SCFβ-TrCP, which enhances the affinity of pSer33/Ser37 β-catenin fo...
SKL2001
T6989
SKL2001, an agonist of the Wnt/β-catenin pathway, can disrupt the Axin/β-catenin interaction.
FH535
T2413
FH535, a Wnt/β-catenin signaling and PPAR inhibitor, exhibits anti-tumor activities.
Gigantol
TL0008
Gigantol is a novel inhibitor of the Wnt/β-catenin pathway. It inhibits Wnt/β-catenin signaling through downregulation of phosphorylated LRP6 and cytosolic β-cat...
NCB-0846
T4011
NCB-0846 is an orally active TNIK inhibitor (IC50: 21 nM).
Wogonin
T2933
Wogonin (Vogonin) is a cell-permeable and orally available flavonoid that displays anti-inflammatory and anticancer properties.
Xanthatin
T3S0153
1. Xanthatin has cytotoxic activity. 2. Xanthatin has antibacterial and antifungal activies against MRSA. 3. Xanthatin may have therapeutic potential against NSC...
FzM1
T24076
FzM1 is a negative allosteric modulator (NAM) of Frizzled receptor FZD4. FzM1 reduces WNT5A-dependent WNT responsive element (WRE) activity (log EC50inh=−6.2). F...
CCT251545
T14907
CCT251545 is an potent and oral-bioavailable WNT signaling inhibitor(IC50 of 5 nM in 7dF3 cells).
Isoquercetin
T5S0754
1. Isoquercetin (3-Glucosylquercetin) is a potential stimulator of bone mineralization used for prophylaxis of osteoporotic disorders. 2. Isoquercetin may be as ...
WAY-262611
T1971
WAY-262611 is a wingless β-Catenin agonist.
Specnuezhenide
T3803
Specnuezhenide (Nuezhenide) significantly protects human neuroblastoma SH-SY5Y cells from 6-hydroxydopamine-induced neurotoxicity.Nuezhenide is the main inhibito...
PRI-724
T64414
PRI-724 (C-82 prodrug) is a selective small-molecule inhibitor of β-catenin/CBP interaction.
Salinomycin sodium salt
TQ0215
Salinomycin sodium salt (Sodium salinomycin), an antibiotic potassium ionophore, is an effective inhibitor of Wnt/β-catenin signaling.
NRX-252262
T9182
NRX-252262 is a potent enhancer of the interaction between β-Catenin, and its cognate E3 ligase, SCFβ-TrCP, induces mutant β-catenin degradation(EC50:3.8 nM)
XAV-939
T1878
XAV-939 (NVP-XAV939) shows the selective inhibition against Wnt/β-catenin-mediated transcription by tankyrase1/2 inhibition (IC50: 11/4 nM in cell-free assays).
Laduviglusib trihydrochloride
T22657
Laduviglusib trihydrochloride (CT99021 trihydrochloride) is a selective glycogen synthase kinase 3 (GSK-3) inhibitor with IC50s of 10 nM and 6.7 nM for GSK-3α an...
EMT inhibitor-1
T11190
EMT inhibitor-1 is an inhibitor of Hippo, Wnt signaling and TGF- macrophages (TGF-) with antitumor activity.
1 2 3 4 5 6 7
TargetMol