TN3468 |
Atractylochromene
|
203443-33-8
|
98%
|
|
Atractylochromene is an inhibitor of β-catenin dependent Wnt pathway, it may be a potential chemotherapeutic agent for the prevention and treatment of human colo...
|
TN1694 |
Gliotoxin
|
67-99-2
|
98%
|
|
Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signalin...
|
TN3525 |
Boehmenan
|
57296-22-7
|
98%
|
|
(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in ...
|
TN3319 |
9-Hydroxycanthin-6-one
|
138544-91-9
|
98%
|
|
9-Hydroxycanthin-6-one might be the active component that contributed to the aphrodisiac effect of E. longifolia by antagonizing the smooth muscle tone of CC as ...
|
TMA1743 |
Ergosterol peroxide
|
2061-64-5
|
98%
|
|
Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Fox...
|
TN2995 |
4,10-Aromadendranediol
|
70051-38-6
|
98%
|
|
4,10-Aromadendranediol exhibits neurite outgrowth-inducing activity in neurons via activation of the ERK signaling pathway, which may be beneficial to the treatm...
|
TN2775 |
2-Methoxystypandrone
|
85122-21-0
|
98%
|
|
2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the inflamm...
|
T12537 |
β-catenin/CBP-IN-1
|
1198780-38-9
|
98%
|
|
β-catenin/CBP-IN-1 is a potent and selective inhibitor of CBP/β-catenin
|
TP1565L |
Foxy-5 acetate
|
TP1565L
|
98%
|
|
Foxy-5 acetate is an agonist of Wnt 5A which is a non-canonical member of the Wnt family. Foxy-5 acetate impairs the migration and invasion of epithelial cancer ...
|
TN4046 |
Excisanin A
|
78536-37-5
|
98%
|
|
ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a pote...
|
T35556 |
GSK-3β inhibitor 8
|
1139875-74-3
|
98%
|
|
GSK-3β inhibitor 8 (GSK3β Inhibitor XVIII) is a potent and selective GSK-3β inhibitor with an IC50 value of 64 nM.GSK-3β inhibitor 8 is a thienopyrimidine deriva...
|
T13078 |
Tankyrase-IN-2
|
1588870-36-3
|
98%
|
|
Tankyrase-IN-2 is a selective, potent and orally active inhibitor of tankyrase with IC50s of 10, 7, and 710 nM for TNKS1, TNKS2 as well as PARP1, respectively
|
T5342 |
IWP-O1
|
2074607-48-8
|
99.98%
|
|
IWP-O1 is a highly potent Porcupine (Porcn) inhibitor (EC50: 80 pM), effectively suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells.
|
T6673 |
SKI II
|
312636-16-1
|
99.97%
|
|
SKI II (SphK-I2) is a highly selective and non-ATP-competitive S1P receptor inhibitor (IC50: 0.5 μM) while exhibiting no inhibitory action on other kinases inclu...
|
T0470 |
Nefopam hydrochloride
|
23327-57-3
|
99.97%
|
|
Nefopam hydrochloride (Nefopam HCl) is the hydrochloride salt form of nefopam, a centrally-acting, non-opioid benzoxazocine with analgesic activity.
|
T7830 |
Windorphen
|
19881-70-0
|
99.96%
|
|
Windorphen is a Wnt inhibitor that selectively abrogates the Wnt signaling.
|
T17256 |
Wnt pathway activator 1
|
1360540-81-3
|
99.94%
|
|
Wnt pathway activator 1 is a potent Wnt activator with an IC50 of 28-29 nM. Wnt pathway activator 1 is a potent Wnt activator for the treatment of androgenetic a...
|
T6768 |
AZ6102
|
1645286-75-4
|
99.91%
|
|
AZ6102 is a potent TNKS1/2 inhibitor that has 100-fold selectivity against other PARP family enzymes and shows IC50 of 5 nM for Wnt pathway inhibition in DLD-1 c...
|
T24076 |
FzM1
|
1680196-54-6
|
99.89%
|
|
FzM1, a negative allosteric modulator (NAM) of the Frizzled receptor FZD4, diminishes WNT5A-dependent WNT responsive element (WRE) activity (log EC50inh=−6.2) by...
|
T9182 |
NRX-252262
|
2438637-61-5
|
99.87%
|
|
NRX-252262 is a potent enhancer of the interaction between β-Catenin, and its cognate E3 ligase, SCFβ-TrCP, induces mutant β-catenin degradation(EC50:3.8 nM)
|