VEGFR

VEGF receptors are receptors for vascular endothelial growth factor (VEGF). There are three main subtypes of VEGFR, numbered 1, 2 and 3. Also, they may be membrane-bound (mbVEGFR) or soluble (sVEGFR), depending on alternative splicing.

Cat. No.	Product name	CAS No.	Purity
T5373	Acrizanib	1229453-99-9	98.72%
T5373	Acrizanib (LHA510) is a VEGFR-2 inhibitor, with an IC50 of 17.4 nM for BaF3-VEGFR-2.
T22737	DMH4	515880-75-8	98.68%
T22737	DMH4 is a potent and selective inhibitor of VEGFR2 with an IC50 of 0.16 µM.
T8496	MAZ51	163655-37-6	98.53%
T8496	MAZ51 is a VEGFR-3 (Flt-4) tyrosine kinase inhibitor.
T10870L	CP-547632	252003-65-9	98.51%
T10870L	CP-547632 is an orally available and potent, ATP-competitive dual inhibitor of VEGFR-2 and FGF kinase F with IC50s of 11 nM and 9 nM, respectively. CP-547632 is ...
T22436	Takeda-6d	1125632-93-0	98.41%
T22436	Takeda-6d, a novel, potent DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor, inhibits B-RAF and VEGFR2 with IC50 of 7.0nM and 2.2nM.
T0374L	Sunitinib	557795-19-4	98.38%
T0374L	Sunitinib (SU 11248) is a multi-targeted receptor tyrosine kinase (RTK) inhibitor that inhibits VEGFR2 and PDGFRβ (IC50=80/2 nM). Sunitinib has antitumor activit...
T6028	PF 477736	952021-60-2	98.34%
T6028	PF 477736 (PF-736,PF-00477736) is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (CS...
T3691	(Rac)-SAR131675	1092539-44-0	98.34%
T3691	(Rac)-SAR131675 is an effective and specific VEGFR-3 inhibitor. It inhibited VEGFR-3 tyrosine kinase activity (IC50: 20 nmol/L) and VEGFR-3 autophosphorylation (...
T6199	Ribociclib	1211441-98-3	98.27%
T6199	Ribociclib (LEE011) is an orally available, and highly specific CDK4/6 inhibitor (IC50：10/39 nM).
T3560	Desmethylanethol trithione	18274-81-2	98.23%
T3560	Desmethylanethol trithione (ADT-OH) is a derivative of anethole dithiolethione (ADT) and synthetic hydrogen sulfide (H2S) donor. In the in vitro glucose-oxygen d...
T0374	Sunitinib Malate	341031-54-7	98.23%
T0374	Sunitinib Malate (Sunitinib) is an indolinone-based tyrosine kinase inhibitor. It blocks the tyrosine kinase activities of VEGFR2, PDGFRβ (IC50: 80/2 nM), and c-...
T2456	Tivozanib	475108-18-0	98.23%
T2456	Tivozanib (KRN951) is an orally bioavailable inhibitor of vascular endothelial growth factor receptors (VEGFRs) 1, 2 and 3 with potential antiangiogenic and anti...
T30855	CGP77675	234772-64-6	98.23%
T30855	CGP77675 (ZINC1488120) is a potent and selective inhibitor of Src family kinase with IC50s of 5-20 and 40 nM for the phosphorylation of peptide substrates and au...
T4053	AST 487	630124-46-8	98.17%
T4053	AST 487 (NVP-AST 487) is a RET kinase inhibitor, inhibiting RET autophosphorylation and activation of downstream effectors. It also can inhibit Flt-3.
T2642	PD173074	219580-11-7	98.15%
T2642	PD173074 is an effective FGFR1 inhibitor (IC50: 25 nM) and also inhibits VEGFR2 (IC50: 100-200 nM) in cell-free assays. The selectivity is higher ~1000-fold for ...
T26852	BMS-605541	639858-32-5	98.07%
T26852	BMS-605541 is a potent and selective inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2) kinase activity(Ki=49 nM).
T3641	NVP-BAW2881	861875-60-7	98.07%
T3641	NVP-BAW2881 (BAW2881) is a potent and selective VEGFR inhibitor (vascular endothelial growth factor receptor tyrosine kinase inhibitor) with activity to inhibit ...
T61899	VEGFR2-IN-1	2765224-55-1	98.06%
T61899	VEGFR2-IN-1 is a selective and potent VEGFR2 inhibitor with antitumor activity that inhibits cell proliferation and migration and can be used in the study of bre...
T22349	JNJ-38158471	951151-97-6	98.04%
T22349	JNJ-38158471 (CS-2660), a highly selective, orally available, well tolerated VEGFR2 inhibitor with IC50 of 40 nM, inhibits closely related tyrosine kinases such ...
TQ0321	BIBF 1202	894783-71-2	98.04%
TQ0321	BIBF 1202 is a VEGFR2 kinase inhibitor (IC50: 62 nM).