Trk receptor

Trk receptors are a family of tyrosine kinases that regulates synaptic strength and plasticity in the mammalian nervous system. Trk receptors affect neuronal survival and differentiation through several signaling cascades.The common ligands of trk receptors are neurotrophins, a family of growth factors critical to the functioning of the nervous system. The binding of these molecules is highly specific. Each type of neurotrophin has different binding affinity toward its corresponding Trk receptor. The activation of Trk receptors by neurotrophin binding may lead to activation of signal cascades resulting in promoting survival and other functional regulation of cells.

Cat. No.	Product name	CAS No.	Purity
T3109	SP600125	129-56-6	99.58%
T3109	SP600125 (JNK Inhibitor II) is a JNK inhibitor that inhibits JNK1, JNK2, and JNK3 (IC50=40/40/90 nM) with oral potency, reversibility, and ATP-competitive proper...
T6880	Larotrectinib sulfate	1223405-08-0	99.49%
T6880	Larotrectinib sulfate (LOXO-101 sulfate) is an oral active and specific ATP-competitive inhibitor of tropomyosin receptor kinases (TRK).
T4257	Belizatinib	1357920-84-3	99.48%
T4257	Belizatinib (TSR-011) is an effective, oral and dual inhibitor of ALK (IC50: 0.7 nM, wild-type recombinant ALK) and TRKA, TRKB, and TRKC.
T40034	GNF-8625 monopyridin-N-piperazine hydrochloride	2412055-62-8	99.44%
T40034	GNF-8625 monopyridin-N-piperazine hydrochloride is a protomyosin receptor kinase (TRK) inhibitor.
TP2068L	Cyclotraxin B acetate(1203586-72-4 free base)	TP2068L	99.42%
TP2068L	Cyclotraxin B acetate is an antagonist of TrkB receptors; inhibits BDNF-induced TrkB activity (IC50 = 0.30 nM). Allosterically alters TrkB receptor conformation ...
T6097	GNF-5837	1033769-28-6	99.29%
T6097	GNF-5837 is a specific, and orally bioavailable pan-TRK inhibitor for TrkA/TrkB (IC50: 8/12 nM).
T22324	Ensartinib hydrochloride	2137030-98-7	99.29%
T22324	Ensartinib hydrochloride (X-396 dihydrochloride) is a potent new-generation ALK inhibitor with high activity against CNS metastases and a broad range of known cr...
T73397	ENT-C225	2919962-53-9	99.16%
T73397	ENT-C225 is a potent TrkB neurotrophin receptor (TrkBR) activator with neuroprotective activity for the study of Alzheimer's disease and Parkinson's disease.
T6712	Tyrphostin AG 879	148741-30-4	99.05%
T6712	Tyrphostin AG 879 (AG 879) effectively inhibits HER2/ErbB2 (IC50: 1 μM), 100- and 500-fold higher selective to ErbB2 than EGFR and PDGFR.
T14921	CE-245677	717899-97-3	98.99%
T14921	CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases. With a cellular IC50s of 4.7 and 1 nM.
T4349	Sitravatinib	1123837-84-2	98.9%
T4349	Sitravatinib (MGCD516) (MGCD516) is an inhibitor targeting multiple RTKs involved in driving sarcoma cell growth, including c-Met, c-Kit, PDGFRα/β, PDGFR, and Ax...
T2349	BMS-754807	1001350-96-4	98.86%
T2349	Dual IGF-1R/InsR Inhibitor BMS-754807 is an oral small molecule inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (InsR) tyrosine ...
T2094	Danusertib	827318-97-8	98.44%
T2094	Danusertib (PHA-739358) is a small-molecule 3-aminopyrazole derivative with potential antineoplastic activity. Danusertib binds to and inhibits the Aurora kinase...
T2816	7,8-Dihydroxyflavone	38183-03-8	98.37%
T2816	7,8-Dihydroxyflavone (7,8-DHF) is a naturally-occurring flavone and exist in Tridax procumbens, Godmania aesculifolia, and primula tree leaves.
T6121	Tepotinib	1100598-32-0	98.35%
T6121	Tepotinib (EMD-1214063) is an inhibitor of MET tyrosine kinase with potential antineoplastic activity.
T8327	ONO-7475	1646839-59-9	98.33%
T8327	ONO-7475 is an inhibitor with high specificity for anexelekto and MER tyrosine kinase
T41224	CG 428	2412055-93-5	98.26%
T41224	CG 428 is a potent tropomyosin receptor Kinase (TRK) Degrader (uSMITETM) with a DC50 of 0.36 nM. CG 428 comprises an analog of the pan-TRK inhibitor GNF-8625 jo...
T4496	LM22B-10	342777-54-2	98.19%
T4496	LM22B-10 is an activator of TrkB/TrkC neurotrophin receptor and can induce TrkB, TrkC, ERK and AKT activation in vitro and in vivo.
T1354	N-Acetyl-5-hydroxytryptamine	1210-83-9	98.03%
T1354	N-Acetyl-5-hydroxytryptamine (O-Demethylmelatonin) , also known as Normelatonin, is the immediate precursor of melatonin. It is produced from serotonin by the en...
T5635	CH7057288	2095616-82-1	98%
T5635	CH7057288 is an effective and selective TRK inhibitor with an IC50 value of 1.1 nM, 7.8 nM and 5.1 nM for TRKA, TRKB and TRKC, respectively.