Topoisomerase

Topoisomerases are enzymes that participate in the overwinding or underwinding of DNA. The winding problem of DNA arises due to the intertwined nature of its double-helical structure. During DNA replication and transcription, DNA becomes overwound ahead of a replication fork.

Cat. No.	Product name	CAS No.	Purity
T11249	Exatecan	171335-80-1	99.69%
T11249	Exatecan (DX-8951f) is a DNA topoisomerase I (TOP1) inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL).Exatecan has antitumor activity and may be used in cance...
T1640	Ciprofloxacin	85721-33-1	99.65%
T1640	Ciprofloxacin (Bay-09867), a synthetic broad spectrum fluoroquinolone antibiotic, inhibits bacterial DNA gyrase. It is more active against Gram-negative bacteria...
T8384	Gatifloxacin hydrochloride	121577-32-0	99.65%
T8384	Gatifloxacin hydrochloride (AM-1155 hydrochloride) is an antibiotic of the fourth-generation fluoroquinolone family, which can inhibit the bacterial enzyme DNA r...
T67826	Alalevonadifloxacin	2892364-59-7	99.63%
T67826	Alalevonadifloxacin is a DNA gyrase and DNA topoisomerase inhibitor and a novel antibacterial compound of the quinolone class targeting MRSa. Alalevonadifloxacin...
T77650	Topoisomerase II inhibitor 14	305343-00-4	99.62%
T77650	Topoisomerase II inhibitor 14 is a potent topoisomerase II inhibitor with anticancer and antioxidant activities.Topoisomerase II inhibitor 14 induces apoptosis a...
T67509	Cholesteryl Hemisuccinate	1510-21-0	99.61%
T67509	Cholesteryl Hemisuccinate (Cholesterol hydrogen succinate) is a highly soluble cholesterol analogue often used in polar solutions for its hepatoprotective, antic...
T1521	(±)-10-Hydroxycamptothecin	64439-81-2	99.58%
T1521	(±)-10-Hydroxycamptothecin (Hydroxy Camptothecine) is an alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selective...
T5394	Prulifloxacin	123447-62-1	99.56%
T5394	Prulifloxacin (NM441) is a broad-spectrum fluoroquinolone antibiotic. It Inhibits bacterial DNA synthesis by inhibiting the activity of bacterial DNA topoisomera...
T1492	Gemifloxacin mesylate	210353-53-0	99.55%
T1492	Gemifloxacin mesylate (Gemifloxacin mesylate) inhibits activities of DNA gyrase and topoisomerase IV, thereby inhibiting DNA replication and eventually bacterial...
T1511	Daunorubicin hydrochloride	23541-50-6	99.53%
T1511	Daunorubicin hydrochloride (Rubidomycin hydrochloride), an anthracycline aminoglycoside antineoplastic, inhibits DNA replication and repair and RNA and protein s...
T0486	Irinotecan hydrochloride trihydrate	136572-09-3	99.52%
T0486	Irinotecan hydrochloride trihydrate (CPT-11 HCl Trihydrate) keeps DNA from unwinding by inhibiting topoisomerase 1.
TQ0063	Zoliflodacin	1620458-09-4	99.51%
TQ0063	Zoliflodacin (ETX0914) (ETX0914, AZD0914) is a new bacterial DNA gyrase/topoisomerase inhibitor. Zoliflodacin has potent in vitro antibacterial activity against ...
T0250	Ciprofloxacin monohydrochloride	93107-08-5	99.5%
T0250	Ciprofloxacin monohydrochloride (Bay-09867 hydrochloride) is a broad-spectrum antimicrobial carboxyfluoroquinoline.
T2764	(S)-10-Hydroxycamptothecin	19685-09-7	99.48%
T2764	(S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor, utilized as a clinical therapy agent against hepatoma.
T68896	Daniquidone	67199-66-0	99.47%
T68896	Daniquidone (Batracylin) is a potent dual inhibitor of DNA topoisomerase I and DNA topoisomerase II with cytotoxic and antiproliferative activity that induces DN...
T77584	Tubulin inhibitor 35	2247047-77-2	99.45%
T77584	Tubulin inhibitor 35 (Tubulin IN 35) is a potent dual inhibitor of topoisomerase I and microtubule protein polymerization with antitumor activity, inhibits migra...
TQ0088	Exatecan Mesylate	169869-90-3	99.44%
TQ0088	Exatecan Mesylate (DX8951f) is a DNA topoisomerase I inhibitor (IC50: 2.2 μM, 0.975 μg/mL).
T26046	Razoxane	21416-67-1	99.42%
T26046	Razoxane is used as an antimitotic agent with immunosuppressive properties.
T1060	Flumequine	42835-25-6	99.4%
T1060	Flumequine (R-802) is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. It functions by inhibiting DNA gyrase, a ...
T4S0797	Berberine	2086-83-1	99.38%
T4S0797	1. Berberine (Umbellatine) is a potent oral hypoglycemic agent with beneficial effects on lipid metabolism. 2. Berberine may as a broad-spectrum anti-microbial m...