TLR

Toll-like receptors (TLRs) are a class of proteins that play a key role in the innate immune system. They are single-pass membrane-spanning receptors usually expressed on sentinel cells such as macrophages and dendritic cells, that recognize structurally conserved molecules derived from microbes.

Cat. No.	Product name	CAS No.	Purity
T16506	PF-4878691	532959-63-0	99.3%
T16506	PF-4878691 (3M-852A) is an effective and selective Toll-like receptor 7 agonists modelled. It is used to dissociate its antiviral and inflammatory activities.
T15020	CU-CPT22	1416324-85-0	99.3%
T15020	CU-CPT22 is the first probe for the complex between toll-like receptors TLR1 and TLR2. CU-CPT22 binds at the interface of TLR1 and TLR2 (IC50 = 0.58 μM). It comp...
T6898	Motolimod	926927-61-9	99.27%
T6898	Motolimod (VTX-378) (VTX-2337) is an effective and specific Toll-like receptor (TLR) 8 agonist (EC50: 100 nM), > 50-fold selectivity over TLR7.
T27034	CL075	256922-53-9	99.25%
T27034	CL075 (3M002) is a selective TLR8 agonist.CL075 has immunomodulatory activity by triggering the MyD88-dependent signaling pathway, activating NF-κB and IRF7 to e...
T10899	CU-CPT17e	2109805-75-4	99.18%
T10899	CU-CPT17e is a potent agonist of TLR(TLR3, TLR8, and TLR9).
T39115	ABR-238901	1638200-22-2	99.15%
T39115	ABR-238901 is an oral, active S100A8/A9 blocker that inhibits the interaction of S100A8/A9 with its receptors RAGE(receptor for advanced glycation end products) ...
T3826	Polygalasaponin F	882664-74-6	99.15%
T3826	Polygalasaponin F has anti-neuroinflammatory activity, can inhibit the release of inflammatory cytokines TNF-α and NO induced by lipopolysaccharides (LPS) and re...
TQ0205	Procyanidin B1	20315-25-7	99.13%
TQ0205	Procyanidin B1, isolated from commonly eaten fruits, binds to the TLR4/MD-2 complex and has anti-inflammatory activity.
T11108	DSR-6434	1059070-10-8	99.12%
T11108	DSR-6434 is a selective agonist of TLR7 with antitumor effect. DSR-6434 exhibits EC50s of 7.2 nM and 4.6 nM for human and mouse.
T9287	Hydroxychloroquine	118-42-3	99.03%
T9287	Hydroxychloroquine (2-[[4-[(7-Chloroquinolin-4-yl)amino]pentyl](ethyl)amino]ethanol) (HCQ) is an alkalinizing lysosomatropic drug that acts by inducing apoptosis...
T4258	TLR7 agonist 2	1642857-69-9	98.98%
T4258	TLR7 agonist 2 (TLR7-IN-1) is a specific and effective Toll-like Receptor 7 (TLR7) agonist (LEC=0.4 μM).
T7347	CU-CPT-8m	125079-83-6	98.97%
T7347	CU-CPT-8m (TLR8-specific antagonist) is an toll-like receptor 8 (TLR8) antagonist (IC50 : 67 nM)
T2S0265	Robinin	301-19-9	98.91%
T2S0265	Flavone glycoside from Robinia with antibacterial and diuretic properties; derived from kaempferol.The ability of robinin to reverse the multidrug resistance of ...
T35349	CU-CPD107	2573912-32-8	98.86%
T35349	CU-CPD107 is a selective agonist of toll-like receptor 8 (TLR8) and also shows activation activity against ssRNA ligands. CU-CPD107 acts as an inhibitor of TLR8...
T6677	Sophocarpine	6483-15-4	98.67%
T6677	Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.
T8316	1V209	1062444-54-5	98.53%
T8316	1V209 (TLR7 agonist T7) is a Toll-like receptor 7 (TLR7) agonist and has anti-tumor effects.
T14513	BBIQ	1229024-57-0	98.02%
T14513	BBIQ is a powerful vaccine adjuvant that enhances innate immune responses and a potent and selectively toll-like receptor 7 (TLR7) agonist with an EC50 of  59.1 ...
T7317	CU-CPT-9a	2165340-32-7	98%
T7317	CU-CPT-9a is a potent TLR8 inhibitor (IC50 : 0.5 nM), that suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells-
T3502	C29	363600-92-4	98%
T3502	C29 is a novel inhibitor of TLR2/1 and TLR2/6 signaling induced by synthetic and bacterial TLR2 agonists in human HEK-TLR2 and THP-1 cells, but only TLR2/1 signa...
T7302	CU-CPT9b	2162962-69-6	98%
T7302	CU-CPT9b (TLR8-specific antagonist 1) is an antagonist of toll-like receptor 8 (TLR8; Kd = 21 nM). It inhibits activation of NF- B induced by the TLR8 agonist R-...