T2048 |
LY-364947
|
396129-53-6
|
99.65%
|
|
LY-364947 (HTS466284) is a potent ATP-competitive inhibitor of TGFβR-I.
|
T2123 |
LY2109761
|
700874-71-1
|
99.64%
|
|
LY2109761 is a novel selective TGF-β receptor type I/II (TβRI/II) dual inhibitor with Ki of 38 nM and 300 nM, respectively; shown to negatively affect the phosph...
|
T5129 |
SRI-011381 hydrochloride
|
2070014-88-7
|
99.59%
|
|
SRI-011381 hydrochloride, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.
|
T10287 |
ALK2-IN-2
|
2254409-25-9
|
99.55%
|
|
ALK2-IN-2 is a potent and selective inhibitor of activin receptor-like kinase 2 (ALK2) (IC50: 9 nM), inhibiting ALK2 700-fold more than ALK3.
|
T6496 |
Vactosertib
|
1352608-82-2
|
99.55%
|
|
Vactosertib (EW-7197) is an orally bioavailable inhibitor of the serine/threonine kinase, transforming growth factor (TGF)-beta receptor type 1 (TGFBR1), also kn...
|
T77786 |
TGFβ-IN-5
|
259870-32-1
|
99.5%
|
|
TGFβ-IN-5 (WAY-641966) is a potent TGFβ inhibitor with anti-prion activity for the study of fibroproliferative diseases associated with TGF-β signaling.
|
TN1040 |
Skullcapflavone II
|
55084-08-7
|
99.5%
|
|
Skullcapflavone II is a flavonoid derived from Scutellaria baicalensis, a widely used herbal medicine in anti-inflammatory and anticancer therapy. Skullcapflavon...
|
T1977 |
Dorsomorphin
|
866405-64-3
|
99.48%
|
|
Dorsomorphin (Compound C) is an effective and specific inhibitor of AMPK (AMP-activated protein kinase), which is induced by AICAR and metformin.
|
T5125 |
LY3200882
|
1898283-02-7
|
99.46%
|
|
LY3200882 is a highly selective inhibitor of TGF-β receptor type 1 (TGFβRI).
|
T12433 |
PF-06952229
|
1801333-55-0
|
99.45%
|
|
PF-06952229 is a selective inhibitor of TGFβRI. PF-06952229 can be used in studies about the treatment of solid tumors, specifically metastatic breast cancer.
|
T62483 |
CJJ300
|
1807631-83-9
|
99.41%
|
|
CJJ300 is a transforming growth factor-β (TGF-β) inhibitor (IC50 : 5.3 μM).CJJ300 inhibits TGF-β signaling by disrupting the formation of the TGF-β-TβR-I-TβR-II ...
|
T1900 |
LDN-212854
|
1432597-26-6
|
99.38%
|
|
LDN-212854 (BMP Inhibitor III), a novel BMP inhibitor, exhibits greater selectivity for BMP versus the TGF-β type I receptors; possesses differences towards ALK2...
|
T73300 |
AXL-IN-13
|
2376928-82-2
|
99.38%
|
|
AXL-IN-13 is a potent and orally active AXL inhibitor with an IC50 value of 1.6 nM and a Kd value of 0.26 nM.AXL-IN-13 exhibits anticancer activity, reverses TGF...
|
T2098 |
A 77-01
|
607737-87-1
|
99.31%
|
|
A 77-01 is a potent inhibitor of TGF-(beta) type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM.
|
T1914 |
K02288
|
1431985-92-0
|
99.27%
|
|
K 02288 is a novel small molecule inhibitor of ALK1/2/3/6.
|
T9947 |
GW-6604
|
452342-37-9
|
99.26%
|
|
GW-6604 is an ALK5 inhibitor and shows clear antifibrotic effects resulting in liver function improvement.
|
T7799 |
BMP signaling agonist sb4
|
100874-08-6
|
99.24%
|
|
BMP signaling agonist sb4 (SB 4) is an agonist of benzoxazole bone morphogenetic protein (BMP) signaling (EC50 :74 nM)
|
T6324 |
(E/Z)-BIX02188
|
1094614-84-2
|
99.21%
|
|
BIX02188 is a specific MEK5 inhibitor (IC50: 4.3 nM), also inhibits ERK5 catalytic activity (IC50: 810 nM), and does not inhibit closely related kinases MEK1/2, ...
|
T10572L |
BMT-124110 Formate
|
T10572L
|
99.17%
|
|
BMT-124110 Formate is a selective AAK1 inhibitor (IC50: 0.9 nM) with anti-injury sensory activity.BMT-124110 Formate inhibits the BMP-2-inducible protein kinase ...
|
T4283 |
SRI-011381
|
1629138-41-5
|
99.11%
|
|
SRI-011381, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.
|