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TGF-beta/Smad

The transforming growth factor beta (TGFB) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiation, apoptosis, cellular homeostasis and other cellular functions. In spite of the wide range of cellular processes that the TGFβ signaling pathway regulates, the process is relatively simple. TGFβ superfamily ligands bind to a type II receptor, which recruits and phosphorylates a type I receptor. The type I receptor then phosphorylates receptor-regulated SMADs (R-SMADs) which can now bind the coSMAD SMAD4. R-SMAD/coSMAD complexes accumulate in the nucleus where they act as transcription factors and participate in the regulation of target gene expression.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T2048 LY-364947 396129-53-6 99.65%
LY-364947
LY-364947 (HTS466284) is a potent ATP-competitive inhibitor of TGFβR-I.
T2123 LY2109761 700874-71-1 99.64%
LY2109761
LY2109761 is a novel selective TGF-β receptor type I/II (TβRI/II) dual inhibitor with Ki of 38 nM and 300 nM, respectively; shown to negatively affect the phosph...
T5129 SRI-011381 hydrochloride 2070014-88-7 99.59%
SRI-011381 hydrochloride
SRI-011381 hydrochloride, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.
T10287 ALK2-IN-2 2254409-25-9 99.55%
ALK2-IN-2
ALK2-IN-2 is a potent and selective inhibitor of activin receptor-like kinase 2 (ALK2) (IC50: 9 nM), inhibiting ALK2 700-fold more than ALK3.
T6496 Vactosertib 1352608-82-2 99.55%
Vactosertib
Vactosertib (EW-7197) is an orally bioavailable inhibitor of the serine/threonine kinase, transforming growth factor (TGF)-beta receptor type 1 (TGFBR1), also kn...
T77786 TGFβ-IN-5 259870-32-1 99.5%
TGFβ-IN-5
TGFβ-IN-5 (WAY-641966) is a potent TGFβ inhibitor with anti-prion activity for the study of fibroproliferative diseases associated with TGF-β signaling.
TN1040 Skullcapflavone II 55084-08-7 99.5%
Skullcapflavone II
Skullcapflavone II is a flavonoid derived from Scutellaria baicalensis, a widely used herbal medicine in anti-inflammatory and anticancer therapy. Skullcapflavon...
T1977 Dorsomorphin 866405-64-3 99.48%
Dorsomorphin
Dorsomorphin (Compound C) is an effective and specific inhibitor of AMPK (AMP-activated protein kinase), which is induced by AICAR and metformin.
T5125 LY3200882 1898283-02-7 99.46%
LY3200882
LY3200882 is a highly selective inhibitor of TGF-β receptor type 1 (TGFβRI).
T12433 PF-06952229 1801333-55-0 99.45%
PF-06952229
PF-06952229 is a selective inhibitor of TGFβRI. PF-06952229 can be used in studies about the treatment of solid tumors, specifically metastatic breast cancer.
T62483 CJJ300 1807631-83-9 99.41%
CJJ300
CJJ300 is a transforming growth factor-β (TGF-β) inhibitor (IC50 : 5.3 μM).CJJ300 inhibits TGF-β signaling by disrupting the formation of the TGF-β-TβR-I-TβR-II ...
T1900 LDN-212854 1432597-26-6 99.38%
LDN-212854
LDN-212854 (BMP Inhibitor III), a novel BMP inhibitor, exhibits greater selectivity for BMP versus the TGF-β type I receptors; possesses differences towards ALK2...
T73300 AXL-IN-13 2376928-82-2 99.38%
AXL-IN-13
AXL-IN-13 is a potent and orally active AXL inhibitor with an IC50 value of 1.6 nM and a Kd value of 0.26 nM.AXL-IN-13 exhibits anticancer activity, reverses TGF...
T2098 A 77-01 607737-87-1 99.31%
A 77-01
A 77-01 is a potent inhibitor of TGF-(beta) type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM.
T1914 K02288 1431985-92-0 99.27%
K02288
K 02288 is a novel small molecule inhibitor of ALK1/2/3/6.
T9947 GW-6604 452342-37-9 99.26%
GW-6604
GW-6604 is an ALK5 inhibitor and shows clear antifibrotic effects resulting in liver function improvement.
T7799 BMP signaling agonist sb4 100874-08-6 99.24%
BMP signaling agonist sb4
BMP signaling agonist sb4 (SB 4) is an agonist of benzoxazole bone morphogenetic protein (BMP) signaling (EC50 :74 nM)
T6324 (E/Z)-BIX02188 1094614-84-2 99.21%
(E/Z)-BIX02188
BIX02188 is a specific MEK5 inhibitor (IC50: 4.3 nM), also inhibits ERK5 catalytic activity (IC50: 810 nM), and does not inhibit closely related kinases MEK1/2, ...
T10572L BMT-124110 Formate T10572L 99.17%
BMT-124110 Formate
BMT-124110 Formate is a selective AAK1 inhibitor (IC50: 0.9 nM) with anti-injury sensory activity.BMT-124110 Formate inhibits the BMP-2-inducible protein kinase ...
T4283 SRI-011381 1629138-41-5 99.11%
SRI-011381
SRI-011381, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.
LY-364947
T2048
LY-364947 (HTS466284) is a potent ATP-competitive inhibitor of TGFβR-I.
LY2109761
T2123
LY2109761 is a novel selective TGF-β receptor type I/II (TβRI/II) dual inhibitor with Ki of 38 nM and 300 nM, respectively; shown to negatively affect the phosph...
SRI-011381 hydrochloride
T5129
SRI-011381 hydrochloride, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.
ALK2-IN-2
T10287
ALK2-IN-2 is a potent and selective inhibitor of activin receptor-like kinase 2 (ALK2) (IC50: 9 nM), inhibiting ALK2 700-fold more than ALK3.
Vactosertib
T6496
Vactosertib (EW-7197) is an orally bioavailable inhibitor of the serine/threonine kinase, transforming growth factor (TGF)-beta receptor type 1 (TGFBR1), also kn...
TGFβ-IN-5
T77786
TGFβ-IN-5 (WAY-641966) is a potent TGFβ inhibitor with anti-prion activity for the study of fibroproliferative diseases associated with TGF-β signaling.
Skullcapflavone II
TN1040
Skullcapflavone II is a flavonoid derived from Scutellaria baicalensis, a widely used herbal medicine in anti-inflammatory and anticancer therapy. Skullcapflavon...
Dorsomorphin
T1977
Dorsomorphin (Compound C) is an effective and specific inhibitor of AMPK (AMP-activated protein kinase), which is induced by AICAR and metformin.
LY3200882
T5125
LY3200882 is a highly selective inhibitor of TGF-β receptor type 1 (TGFβRI).
PF-06952229
T12433
PF-06952229 is a selective inhibitor of TGFβRI. PF-06952229 can be used in studies about the treatment of solid tumors, specifically metastatic breast cancer.
CJJ300
T62483
CJJ300 is a transforming growth factor-β (TGF-β) inhibitor (IC50 : 5.3 μM).CJJ300 inhibits TGF-β signaling by disrupting the formation of the TGF-β-TβR-I-TβR-II ...
LDN-212854
T1900
LDN-212854 (BMP Inhibitor III), a novel BMP inhibitor, exhibits greater selectivity for BMP versus the TGF-β type I receptors; possesses differences towards ALK2...
AXL-IN-13
T73300
AXL-IN-13 is a potent and orally active AXL inhibitor with an IC50 value of 1.6 nM and a Kd value of 0.26 nM.AXL-IN-13 exhibits anticancer activity, reverses TGF...
A 77-01
T2098
A 77-01 is a potent inhibitor of TGF-(beta) type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM.
K02288
T1914
K 02288 is a novel small molecule inhibitor of ALK1/2/3/6.
GW-6604
T9947
GW-6604 is an ALK5 inhibitor and shows clear antifibrotic effects resulting in liver function improvement.
BMP signaling agonist sb4
T7799
BMP signaling agonist sb4 (SB 4) is an agonist of benzoxazole bone morphogenetic protein (BMP) signaling (EC50 :74 nM)
(E/Z)-BIX02188
T6324
BIX02188 is a specific MEK5 inhibitor (IC50: 4.3 nM), also inhibits ERK5 catalytic activity (IC50: 810 nM), and does not inhibit closely related kinases MEK1/2, ...
BMT-124110 Formate
T10572L
BMT-124110 Formate is a selective AAK1 inhibitor (IC50: 0.9 nM) with anti-injury sensory activity.BMT-124110 Formate inhibits the BMP-2-inducible protein kinase ...
SRI-011381
T4283
SRI-011381, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.
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TargetMol