T5124 |
SRT 1720 dihydrochloride[925434-55-5(free base)]
|
T5124
|
98.43%
|
|
SRT 1720 is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2 (EC1.5: 37 μM) and SIRT3 (EC1.5: 300 μM).
|
T5490 |
AK-7
|
420831-40-9
|
98.4%
|
|
AK-7 is a brain-permeable SIRT2 inhibitor and to characterize its cholesterol-reducing properties in neuronal models with an IC50 of 15.5 μM.
|
T2879 |
Fisetin
|
528-48-3
|
98.31%
|
|
Fisetin is a natural flavonol extracted from Rhus succedanea L that is structurally and functionally related to kaempferol, can modulate sirtuins,with antioxidan...
|
T22026 |
AGK7
|
304896-21-7
|
98.31%
|
|
AGK7 is an inactive control of AGK2, a selective SIRT2 inhibitor that selectively inhibits SIRT3 over SIRT1 and SIRT2 (IC50 = >5 μM, >50 μM and >50 μM for SIRT3,...
|
T12919 |
SIRT-IN-2
|
1431411-66-3
|
98.26%
|
|
SIRT-IN-2 is a potent SIRT1/2/3 inhibitor(IC50s of 4, 1, 7 μM, respectively).
|
T3S0175 |
Gardenia yellow
|
94238-00-3
|
98.24%
|
|
Gardenia yellow (Crocin I) has anti atherosclerosis and hypolipidemic effects.
|
T12921 |
SIRT5 inhibitor 1
|
2166487-21-2
|
98.06%
|
|
SIRT5 inhibitor 1 is a potent and selective inhibitor of human Sirtuin 5 deacylase (IC50: 0.11 μM). sIRT5 inhibitor 1 is associated with ageing-related diseases....
|
T5S1133 |
Ganoderic acid D
|
108340-60-9
|
98.06%
|
|
1. Ganoderic acid D is one of the major components in Ganoderma triterpenes. 2. Ganoderic acid D treatment for 48h inhibits the proliferation of HeLa human cervi...
|
T1818 |
Tenovin-6
|
1011557-82-6
|
97.71%
|
|
Tenovin-6 is a p53 transcriptional activity agonist.
|
T1887 |
Inauhzin
|
309271-94-1
|
97.69%
|
|
Inauhzin (INZ)(INZ) is a novel small molecule that effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human Y cells wi...
|
T3953 |
Salermide
|
1105698-15-4
|
97.62%
|
|
Salermide is an inhibitor of Sirt1 and Sirt2, causing strong cancer-specific apoptotic cell death.
|
T8346 |
SRT 1460
|
925432-73-1
|
97.62%
|
|
SRT 1460 is a SIRT1 activator.
|
T2160 |
Suramin Sodium Salt
|
129-46-4
|
97.47%
|
|
Suramin Sodium Salt (BAY-205) is a sodium salt form of suramin, a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding...
|
T22094 |
JGB1741
|
1256375-38-8
|
97.24%
|
|
JGB1741 (ILS-JGB-1741) is a potent and selective inhibitor of SIRT1 with an IC50 of 15 μM. JGB1741 modulates Bax/Bcl2 ratio, cytochrome c release and PARP cleava...
|
T9320 |
YK-3-237
|
1215281-19-8
|
96.38%
|
|
YK-3-237 (B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid) reduces acetylation of mtp53 and exhibits anti-proliferative e...
|
T4108 |
3-TYP
|
120241-79-4
|
100.00%
|
|
3-TYP (3-(1H-1,2,3-triazol-4-yl) pyridine) is a selective SIRT3 inhibitor.
|
T77697 |
BML-278
|
120533-76-8
|
100%
|
|
BML-278 is a SIRT1 activator with an EC150 of 1 μM.BML-278 increases H3K9 methylation and inhibits H3K9 acetylation in parental and maternal prokaryotes, and can...
|
T28543 |
RK-9123016
|
955900-27-3
|
100%
|
|
RK-9123016 is a SIRT2 inhibitor. RK-9123016 increases the acetylation level of eukaryotic translation initiation factor 5A (eIF5A), a physiological substrate of ...
|
T8480 |
Tenovin-6 Hydrochloride
|
1011301-29-3
|
100%
|
|
Tenovin-6 Hydrochloride is an SIRT1, SIRT2 and HDAC8 inhibitor(IC50s of 21 μM, 10 μM, and 67 μM for SirT1, SirT2, and SirT3, respectively), and is also a potent ...
|
T64529 |
MDL-800
|
2275619-53-7
|
100%
|
|
MDL-800 is a SIRT6 modulator with antitumor activity for the study of hepatocellular carcinoma and non-small cell lung cancer.
|