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Sirtuin

Sirtuins are a class of proteins that possess either mono-ADP-ribosyltransferase, or deacylase activity, including deacetylase, desuccinylase, demalonylase, demyristoylase and depalmitoylase activity. The name Sir2 comes from the yeast gene 'silent mating-type information regulation 2', the gene responsible for cellular regulation in yeast.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T4328 OSS_128167 887686-02-4 99.25%
OSS_128167
OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 μM), SIRT1(IC50=1578 μM) and SIRT2(IC50=751 μM).
T2S0300 Dihydrocoumarin 119-84-6 99.19%
Dihydrocoumarin
Dihydrocoumarin (melilotin) is a compound found in Melilotus officinalis. Dihydrocoumarin is a yeast Sir2p inhibitor. Dihydrocoumarin also inhibits human SIRT1 a...
T6371 AGK2 304896-28-4 99.17%
AGK2
AGK2(IC50=3.5 μM) is an effective, and specific SIRT2 inhibitor.
TN1071 Ophiopogonin D' 65604-80-0 99.13%
Ophiopogonin D'
Ophiopogonin D' can activate SIRT1 in a dose-dependent manner. Ophiopogonin D' also noncompetitively inhibits UGT1A6 and UGT1A10.
T3447 Thiomyristoyl 1429749-41-6 99.13%
Thiomyristoyl
Thiomyristoyl is an effective and selective SIRT2 inhibitor (IC50: 28 nM). It inhibits SIRT1 (IC50: 98 μM) but no effect on SIRT3 even at 200 μM.
T12920 Sirt2-IN-1 1862238-00-3 99.05%
Sirt2-IN-1
Sirt2-IN-1 is an inhibitor of sirtuin 2 (IC50 = 163 nM).
T60001 Benzamide, 3-methoxy-N-(3-thiazolo[5,4-b]pyridin-2-ylphenyl) 863589-52-0 99.02%
Benzamide, 3-methoxy-N-(3-thiazolo[5,4-b]pyridin-2-ylphenyl)
Benzamide, 3-methoxy-N-(3-thiazolo[5,4-b]pyridin-2-ylphenyl) (3-methoxy-N-(3-(thiazolo[5,4-b]pyridin-2-yl)phenyl)benzamide) is a sirtuin modulator and useful for...
T5618 AK-1 330461-64-8 99.01%
AK-1
AK-1 is a sirtuin 2 (SIRT2) inhibitor (IC50:12.5 µM).that prevents hippocampal neurodegeneration in Alzheimer's disease models and induces cell cycle arrest in c...
T6984 SirReal2 709002-46-0 98.96%
SirReal2
SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.
T4062 CAY10602 374922-43-7 98.87%
CAY10602
CAY10602 is a SIRT1 activator. CAY10602 was derived from high throughput screening for compounds that increase SIRT1-mediated deacetylation of a SIRT1-specific s...
T9106 E1231 1031195-19-3 98.86%
E1231
E1231 is an activator of SIRT1 . E1231 protects from experimental atherosclerosis and lowers plasma cholesterol and triglycerides by enhancing ABCA1 expression.
T24793 SIRT6-IN-5 891002-11-2 98.84%
SIRT6-IN-5
SIRT6-IN-5(SIRT6 inhibitor 5) is a potent and selective SIRT6 inhibitor with an IC50 value of 34 μM.SIRT6-IN-5 is immunosuppressive and chemo-sensitizing, increa...
T11962 MC3482 T11962 98.72%
MC3482
MC3482 is a specific inhibitor of sirtuin5 (SIRT5).
T35347 Et-29 2166487-23-4 98.69%
Et-29
Et-29 is a selective inhibitor of SIRT5 inhibitor with a Ki of 40 nM.
T6678 Splitomicin 5690-03-9 98.64%
Splitomicin
Splitomicin (1-Naphthalenepropanoic Acid) (IC50 of 60 μM), a specific inhibitor of NAD(+)-dependent histone deacetylase Sir2p, displays a high activity in a cell...
T13795 Nicotinamide riboside 1341-23-7 98.61%
Nicotinamide riboside
Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-in...
T4019 Cambinol 14513-15-6 98.47%
Cambinol
Cambinol (SIRT1/2 Inhibitor IV) is a cell-permeable b-naphthol compound that inhibits the NAD-dependent deacetylase activity of SIRT1/2 (IC50: 56/59 μM, respecti...
T5124 SRT 1720 dihydrochloride[925434-55-5(free base)] T5124 98.43%
SRT 1720 dihydrochloride[925434-55-5(free base)]
SRT 1720 is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2 (EC1.5: 37 μM) and SIRT3 (EC1.5: 300 μM).
T5490 AK-7 420831-40-9 98.4%
AK-7
AK-7 is a brain-permeable SIRT2 inhibitor and to characterize its cholesterol-reducing properties in neuronal models with an IC50 of 15.5 μM.
T2879 Fisetin 528-48-3 98.31%
Fisetin
Fisetin is a natural flavonol extracted from Rhus succedanea L that is structurally and functionally related to kaempferol, can modulate sirtuins,with antioxidan...
OSS_128167
T4328
OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 μM), SIRT1(IC50=1578 μM) and SIRT2(IC50=751 μM).
Dihydrocoumarin
T2S0300
Dihydrocoumarin (melilotin) is a compound found in Melilotus officinalis. Dihydrocoumarin is a yeast Sir2p inhibitor. Dihydrocoumarin also inhibits human SIRT1 a...
AGK2
T6371
AGK2(IC50=3.5 μM) is an effective, and specific SIRT2 inhibitor.
Ophiopogonin D'
TN1071
Ophiopogonin D' can activate SIRT1 in a dose-dependent manner. Ophiopogonin D' also noncompetitively inhibits UGT1A6 and UGT1A10.
Thiomyristoyl
T3447
Thiomyristoyl is an effective and selective SIRT2 inhibitor (IC50: 28 nM). It inhibits SIRT1 (IC50: 98 μM) but no effect on SIRT3 even at 200 μM.
Sirt2-IN-1
T12920
Sirt2-IN-1 is an inhibitor of sirtuin 2 (IC50 = 163 nM).
Benzamide, 3-methoxy-N-(3-thiazolo[5,4-b]pyridin-2-ylphenyl)
T60001
Benzamide, 3-methoxy-N-(3-thiazolo[5,4-b]pyridin-2-ylphenyl) (3-methoxy-N-(3-(thiazolo[5,4-b]pyridin-2-yl)phenyl)benzamide) is a sirtuin modulator and useful for...
AK-1
T5618
AK-1 is a sirtuin 2 (SIRT2) inhibitor (IC50:12.5 µM).that prevents hippocampal neurodegeneration in Alzheimer's disease models and induces cell cycle arrest in c...
SirReal2
T6984
SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.
CAY10602
T4062
CAY10602 is a SIRT1 activator. CAY10602 was derived from high throughput screening for compounds that increase SIRT1-mediated deacetylation of a SIRT1-specific s...
E1231
T9106
E1231 is an activator of SIRT1 . E1231 protects from experimental atherosclerosis and lowers plasma cholesterol and triglycerides by enhancing ABCA1 expression.
SIRT6-IN-5
T24793
SIRT6-IN-5(SIRT6 inhibitor 5) is a potent and selective SIRT6 inhibitor with an IC50 value of 34 μM.SIRT6-IN-5 is immunosuppressive and chemo-sensitizing, increa...
MC3482
T11962
MC3482 is a specific inhibitor of sirtuin5 (SIRT5).
Et-29
T35347
Et-29 is a selective inhibitor of SIRT5 inhibitor with a Ki of 40 nM.
Splitomicin
T6678
Splitomicin (1-Naphthalenepropanoic Acid) (IC50 of 60 μM), a specific inhibitor of NAD(+)-dependent histone deacetylase Sir2p, displays a high activity in a cell...
Nicotinamide riboside
T13795
Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-in...
Cambinol
T4019
Cambinol (SIRT1/2 Inhibitor IV) is a cell-permeable b-naphthol compound that inhibits the NAD-dependent deacetylase activity of SIRT1/2 (IC50: 56/59 μM, respecti...
SRT 1720 dihydrochloride[925434-55-5(free base)]
T5124
SRT 1720 is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2 (EC1.5: 37 μM) and SIRT3 (EC1.5: 300 μM).
AK-7
T5490
AK-7 is a brain-permeable SIRT2 inhibitor and to characterize its cholesterol-reducing properties in neuronal models with an IC50 of 15.5 μM.
Fisetin
T2879
Fisetin is a natural flavonol extracted from Rhus succedanea L that is structurally and functionally related to kaempferol, can modulate sirtuins,with antioxidan...
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TargetMol