T4328 |
OSS_128167
|
887686-02-4
|
99.25%
|
|
OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 μM), SIRT1(IC50=1578 μM) and SIRT2(IC50=751 μM).
|
T2S0300 |
Dihydrocoumarin
|
119-84-6
|
99.19%
|
|
Dihydrocoumarin (melilotin) is a compound found in Melilotus officinalis. Dihydrocoumarin is a yeast Sir2p inhibitor. Dihydrocoumarin also inhibits human SIRT1 a...
|
T6371 |
AGK2
|
304896-28-4
|
99.17%
|
|
AGK2(IC50=3.5 μM) is an effective, and specific SIRT2 inhibitor.
|
TN1071 |
Ophiopogonin D'
|
65604-80-0
|
99.13%
|
|
Ophiopogonin D' can activate SIRT1 in a dose-dependent manner. Ophiopogonin D' also noncompetitively inhibits UGT1A6 and UGT1A10.
|
T3447 |
Thiomyristoyl
|
1429749-41-6
|
99.13%
|
|
Thiomyristoyl is an effective and selective SIRT2 inhibitor (IC50: 28 nM). It inhibits SIRT1 (IC50: 98 μM) but no effect on SIRT3 even at 200 μM.
|
T12920 |
Sirt2-IN-1
|
1862238-00-3
|
99.05%
|
|
Sirt2-IN-1 is an inhibitor of sirtuin 2 (IC50 = 163 nM).
|
T60001 |
Benzamide, 3-methoxy-N-(3-thiazolo[5,4-b]pyridin-2-ylphenyl)
|
863589-52-0
|
99.02%
|
|
Benzamide, 3-methoxy-N-(3-thiazolo[5,4-b]pyridin-2-ylphenyl) (3-methoxy-N-(3-(thiazolo[5,4-b]pyridin-2-yl)phenyl)benzamide) is a sirtuin modulator and useful for...
|
T5618 |
AK-1
|
330461-64-8
|
99.01%
|
|
AK-1 is a sirtuin 2 (SIRT2) inhibitor (IC50:12.5 µM).that prevents hippocampal neurodegeneration in Alzheimer's disease models and induces cell cycle arrest in c...
|
T6984 |
SirReal2
|
709002-46-0
|
98.96%
|
|
SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.
|
T4062 |
CAY10602
|
374922-43-7
|
98.87%
|
|
CAY10602 is a SIRT1 activator. CAY10602 was derived from high throughput screening for compounds that increase SIRT1-mediated deacetylation of a SIRT1-specific s...
|
T9106 |
E1231
|
1031195-19-3
|
98.86%
|
|
E1231 is an activator of SIRT1 . E1231 protects from experimental atherosclerosis and lowers plasma cholesterol and triglycerides by enhancing ABCA1 expression.
|
T24793 |
SIRT6-IN-5
|
891002-11-2
|
98.84%
|
|
SIRT6-IN-5(SIRT6 inhibitor 5) is a potent and selective SIRT6 inhibitor with an IC50 value of 34 μM.SIRT6-IN-5 is immunosuppressive and chemo-sensitizing, increa...
|
T11962 |
MC3482
|
T11962
|
98.72%
|
|
MC3482 is a specific inhibitor of sirtuin5 (SIRT5).
|
T35347 |
Et-29
|
2166487-23-4
|
98.69%
|
|
Et-29 is a selective inhibitor of SIRT5 inhibitor with a Ki of 40 nM.
|
T6678 |
Splitomicin
|
5690-03-9
|
98.64%
|
|
Splitomicin (1-Naphthalenepropanoic Acid) (IC50 of 60 μM), a specific inhibitor of NAD(+)-dependent histone deacetylase Sir2p, displays a high activity in a cell...
|
T13795 |
Nicotinamide riboside
|
1341-23-7
|
98.61%
|
|
Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-in...
|
T4019 |
Cambinol
|
14513-15-6
|
98.47%
|
|
Cambinol (SIRT1/2 Inhibitor IV) is a cell-permeable b-naphthol compound that inhibits the NAD-dependent deacetylase activity of SIRT1/2 (IC50: 56/59 μM, respecti...
|
T5124 |
SRT 1720 dihydrochloride[925434-55-5(free base)]
|
T5124
|
98.43%
|
|
SRT 1720 is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2 (EC1.5: 37 μM) and SIRT3 (EC1.5: 300 μM).
|
T5490 |
AK-7
|
420831-40-9
|
98.4%
|
|
AK-7 is a brain-permeable SIRT2 inhibitor and to characterize its cholesterol-reducing properties in neuronal models with an IC50 of 15.5 μM.
|
T2879 |
Fisetin
|
528-48-3
|
98.31%
|
|
Fisetin is a natural flavonol extracted from Rhus succedanea L that is structurally and functionally related to kaempferol, can modulate sirtuins,with antioxidan...
|