Sirtuin

Sirtuins are a class of proteins that possess either mono-ADP-ribosyltransferase, or deacylase activity, including deacetylase, desuccinylase, demalonylase, demyristoylase and depalmitoylase activity. The name Sir2 comes from the yeast gene 'silent mating-type information regulation 2', the gene responsible for cellular regulation in yeast.

Cat. No.	Product name	CAS No.	Purity
T6671	Sirtinol	410536-97-9	99.96%
T6671	Sirtinol is a selective SIRT1/2 inhibitor (IC50: 131/38 μM).
T2412	SRT1720 hydrochloride	1001645-58-4	99.93%
T2412	SRT1720 hydrochloride (SRT1720 HCl) is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2/SIRT3 (EC1.5s: 37 μM/300 μM).
T1873	Tenovin-3	1011301-27-1	99.93%
T1873	Tenovin-3 acts as a p53 activator.
T1558	Resveratrol	501-36-0	99.9%
T1558	Resveratrol (SRT 501) is a polyphenolic natural product, a plant antitoxin with antioxidant and chemopreventive activities. Resveratrol has a wide range of targe...
T9998	MIND4-19	129544-85-0	99.9%
T9998	MIND4-19 is an inhibitor of SIRT2 with antitumor activity.
T4S1173	Agrimol B	55576-66-4	99.89%
T4S1173	1. Agrimol B is a main active ingredient isolated from Agrimonia pilosa Ledeb.
T3888	Scopolin	531-44-2	99.87%
T3888	Scopolin (Scopoloside) formation is increased by the enhanced activity of PAL. Scopolin can reduce the clinical symptoms of rat AIA by inhibiting inflammation an...
T5725	Salvianolic acid B	121521-90-2	99.86%
T5725	Salvianolic acid B (Dan Shen Suan B) is a water-soluble antioxidant from Salvia extract. It plays significant role of antioxidant effect; antiplatelet aggregatio...
T6679	SRT 2104	1093403-33-8	99.83%
T6679	SRT 2104 (GSK2245840) is a selective and brain-permeable SIRT1 activator.
T39233	SIRT7 inhibitor 97491	1807758-81-1	99.79%
T39233	SIRT7 inhibitor 97491 is an HDAC inhibitor with high specificity for SIRT7 (IC50 = 325 nM). SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.
T15263	Selisistat R-enantiomer	848193-69-1	99.78%
T15263	Selisistat R-enantiomer (EX-527 (R-enantiomer)) is a SIRT1 inhibitor with much less activity than the R-enantiomer of Selisistat (IC50 of SIRT1 > 100 μM).
T7679	UBCS039	358721-70-7	99.75%
T7679	UBCS039 is the first synthetic Sirt6 activator(EC50 : 38 μM)
T5096	SRT 1720	925434-55-5	99.7%
T5096	SRT 1720 is a selective activator of human SIRT1 (EC1.5: 0.16 μM) and is >230-fold less potent for SIRT2 and SIRT3.
T77653	Z26395438	2803-63-6	99.63%
T77653	Z26395438 is an inhibitor of Sirtuin-1 with IC50 of 1.6 μM.
T13795	Nicotinamide riboside	1341-23-7	99.58%
T13795	Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-in...
T6111	Selisistat	49843-98-3	99.54%
T6111	Selisistat (EX-527) is a potent and specific inhibitor of the deacetylase SIRT1 (IC50=38 nM). Selisistat can be used in the study of neurological disorders such ...
T62515	SIRT2-IN-9	522650-91-5	99.5%
T62515	SIRT2-IN-9 is a selective SRIT2 inhibitor with an IC50 value of 1.3 μM.SIRT2-IN-9 inhibits the proliferation of MCF-7 breast cancer cells.SIRT2-IN-9 can be used ...
T9999	Sirtuin modulator 2	667910-69-2	99.47%
T9999	Sirtuin modulator 2 (N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide) exhibits antidiabetic, anti-inflammatory and antitumor activities.
T1919	Tenovin-1	380315-80-0	99.44%
T1919	Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination.
T21679	4'-bromo-Resveratrol	1224713-90-9	99.4%
T21679	4'-bromo-Resveratrolis a potent inhibitor of the deacetylases sirtuin 1 (SIRT1) and 3 (SIRT3)