T16667 |
PROTAC Sirt2 Degrader-1
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2098487-75-1
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98%
|
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PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a b...
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T33663 |
Nicotinamide Riboside Triflate
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445489-49-6
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98%
|
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Nicotinamide Riboside Triflate (SRT647 Triflate) is a natural NAD precursor that increases NAD levels, enhances oxidative metabolism and prevents obesity induced...
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T78802 |
SIRT5 inhibitor 6
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2834736-82-0
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98%
|
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SIRT5 Inhibitor 6 is a potent, selective, and substrate-competitive inhibitor of SIRT5, exhibiting an IC50 of 3.0 μM, and demonstrates therapeutic potential for ...
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T78803 |
SIRT5 inhibitor 7
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2951090-00-7
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98%
|
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SIRT5 inhibitor 7 (compound 58), a selective and substrate-competitive SIRT5 inhibitor, exhibits anti-inflammatory properties by modulating protein succinylation...
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T78856 |
SIRT5 inhibitor 8
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98%
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SIRT5 inhibitor 8 (compound 10) serves as a competitive inhibitor of sirtuin SIRT5, exhibiting an IC50 of 5.38 μM, and possesses anticancer potential [1].
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T78857 |
SIRT5 inhibitor 9
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98%
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SIRT5 inhibitor 9 (compound 14), with an IC50 of 4.07 μM, is a competitive inhibitor of the sirtuin SIRT5, exhibiting potential anticancer properties [1].
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T79563 |
Sirt1/2-IN-2
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670267-73-9
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98%
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Sirt1/2-IN-2 (compound hsa55) serves as a dual inhibitor for SIRT1 with an IC50 of 1.8 μM and SIRT2 with an IC50 of 2.4 μM, respectively. It effectively inhibits...
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T79564 |
Sirt1/2-IN-3
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301313-42-8
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98%
|
|
Sirt1/2-IN-3 (compound PS9) serves as a dual inhibitor of SIRT1/2, exhibiting IC50 values of 1.4 μM (SIRT1) and 2.0 μM (SIRT2), respectively. This compound effec...
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T79565 |
Sirt1/2-IN-4
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98%
|
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Sirt1/2-IN-4 (compound PS3) is a potent triple inhibitor of SIRT1, SIRT2, and SIRT3, exhibiting IC50 values of 1.2 μM (SIRT1), 1.9 μM (SIRT2), and 18.6 μM (SIRT3...
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T79601 |
SPC-180002
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2170274-53-8
|
98%
|
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SPC-180002, a dual SIRT1/3 inhibitor, exhibits IC50 values of 1.13 and 5.41 μM for SIRT1 and SIRT3, respectively. It disrupts redox homeostasis through ROS gener...
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T79689 |
SIRT6-IN-3
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3023471-40-8
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98%
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SIRT6-IN-3 (compound 8a), a selective SIRT6 inhibitor (IC50 = 7.49 μM), impedes the proliferation of pancreatic ductal adenocarcinoma (PDAC) cells and prompts ap...
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T79903 |
Sirtuin-1 inhibitor 1
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945114-10-3
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98%
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Sirtuin-1 Inhibitor 1 (Compound 8) is a compound that impedes Sirtuin-1, a protein implicated in obesity-induced diabetes and aging-associated diseases [1].
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T80752 |
YM-08
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812647-88-4
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98%
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YM-08 (Compound 7a), a brain-penetrant SIRT2 inhibitor, exhibits an IC50 of 19.9 μM. Additionally, it acts as an inhibitor of Hsp70 [1].
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T80813 |
WAY-354574
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851873-40-0
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98%
|
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WAY-354574 is an active compound that targets the deacetylase Sirtuin, utilized in research focused on Huntington's disease (HD) [1].
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T81154 |
SIRT1 activator 1
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98%
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SIRT1 Activator 1 (Compound 3), a marine-derived xyloallenoide A derivative from the Xylaria sp. mangrove fungus, exhibits angiogenic effects in zebrafish and pr...
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T81831 |
MDL-811
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2275619-98-0
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98%
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MDL-811, an allosteric activator of SIRT6, markedly enhances the deacetylation of histone H3 at lysine residues 9, 18, and 56 (H3K9Ac, H3K18Ac, and H3K56Ac), pre...
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T82168 |
HSP70/SIRT2-IN-1
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98%
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HSP70/SIRT2-IN-1 (Compound 2a) serves as a dual inhibitor targeting both SIRT2 and HSP70, exhibiting an IC50 of 17.3±2.0 μM against SIRT2. This compound possesse...
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T82458 |
Epigenetic factor-IN-1
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2640673-56-7
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98%
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Epigenetic factor-IN-1 (40569Z) is an epigenetic factor inhibitor that exhibits potent binding affinity for SIRT7. It is utilized in the study of liver cancer [1...
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T72637 |
SIRT5 inhibitor 5
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2883730-60-5
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98%
|
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SIRT5 Inhibitor 5 is a potent substrate-competitive inhibitor of SIRT5, exhibiting an IC50 of 0.21 µM, and does not interact with the NAD+-binding pocket [1].
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T13001 |
SRT3657
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1383551-17-4
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98%
|
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SRT3657 is a brain-permeable SIRT1 activator, has neuroprotective effect.
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