S1P Receptor

The sphingosine-1-phosphate receptors are a class of G protein-coupled receptors that are targets of the lipid signalling molecule Sphingosine-1-phosphate (S1P). They are divided into five subtypes: S1PR1, S1PR2, S1PR3, S1PR4 and S1PR5. .

Cat. No.	Product name	CAS No.	Purity
T17237	VPC 23019	449173-19-7	98%
T17237	VPC 23019 is a competitive antagonist at the S1P1 and S1P3 receptors (pKi= 7.86 and 5.93, respectively). It is also an agonist at the S1P4 and S1P5 receptors (pE...
T12927	SK1-IN-1	1218816-71-7	98%
T12927	SK1-IN-1 is a potent inhibitor of sphingosine kinase 1 (SPHK1)(IC50 of 58 nM).
T12436	PF-543 Citrate	1415562-83-2	98%
T12436	PF-543 Citrate is an inhibitor of sphingosine-competitive SPHK1(IC50 of 2 nM ).
T6673	SKI II	312636-16-1	99.97%
T6673	SKI II (SphK-I2) is a highly selective and non-ATP-competitive S1P receptor inhibitor (IC50: 0.5 μM) while exhibiting no inhibitory action on other kinases inclu...
T4031	S1p receptor agonist 1	1514888-56-2	99.94%
T4031	S1p receptor agonist 1 (S1p-receptor-agonist-1) is an S1P receptor agonist.
T8840	PF-543 hydrochloride	1706522-79-3	99.92%
T8840	PF-543 hydrochloride (PF-543) inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isofo...
TQ0064	Peretinoin	81485-25-8	99.86%
TQ0064	Peretinoin (NIK333) is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as RXR and RAR.
T7939	Fingolimod	162359-55-9	99.76%
T7939	Fingolimod (FTY-720A) is an antagonist of sphingosine 1-phosphate (S1P) (IC50 of 0.033 nM in K562 and NK cells).
T6923	Ozanimod	1306760-87-1	99.74%
T6923	Ozanimod (RPC-1063) (RPC1063) is a specific oral S1P Receptor 1 modulator. Ozanimod has been used in trials studying the treatment of Crohn's Disease, Ulcerative...
T17183	TY-52156	934369-14-9	99.73%
T17183	TY-52156 is an effective and selective S1P3 receptor antagonist (Ki: 110 nM).
T10305	Amiselimod hydrochloride	942398-84-7	99.68%
T10305	Amiselimod hydrochloride (MT-1303 hydrochloride) is a sphingosine 1-phosphate receptor-1 (S1P1) modulator.
T8461	SKI V	24418-86-8	99.62%
T8461	SKI V is a potent and noncompetitive non-lipid sphingosine kinase (SPHK; SK) inhibitor (GST-hSK,IC50 : 2 μM), and is a PI3K inhibitor(hPI3k,IC50 : 6 μM), induces...
T2171	SEW2871	256414-75-2	99.62%
T2171	SEW 2871 is an orally available, highly selective S1P1 agonist with an EC50 of 13.8 nM.It reduces the number of lymphocytes in the blood and is used in studies r...
T10385	ASP-4058	952565-91-2	99.51%
T10385	ASP-4058 is a selective, safe, and orally active second-generation agonist of sphingosine phosphate receptors 1 and 5 (S1P1 and S1P5).ASP-4058 ameliorates experi...
T38826	Vibozilimod	1403232-33-6	99.47%
T38826	Vibozilimod (SCD-044) is S1P receptor-1 (S1PR1) agonist .
T4658	MHP	1104874-94-3	99.45%
T4658	MHP (Methyl caprooyl tyrosinate) is an activator of sphingosine kinase (SPHK1), and significantly stimulates CAMP mRNA and protein production in KC.
T15032	CYM50308	1345858-76-5	99.43%
T15032	CYM50308 is a high affinity agonist of sphingosine-1-phosphate receptor 4 (S1P4-R) (EC50: 56 nM). CYM50308 has no activity at S1P1-R, S1P2-R and S1P3-R subtypes ...
T3258	Ponesimod	854107-55-4	99.42%
T3258	Ponesimod (ACT-128800) is an orally available sphingosine-1-phosphate receptor 1 (S1PR1, S1P1) agonist with potential immunomodulating activity.
T63047	SLP9101555	T63047	99.40%
T63047	SLP9101555 is a potent and selective sphingosine kinase 2 (SphK2) inhibitor with a Ki of 90 nM.SLP9101555 has a high affinity for SphK2, which is 200-fold higher...
T60204	W140 HBr	1246817-25-3	99.34%
T60204	[(3S)-3-amino-4-(3-hexylanilino)-4-oxobutyl]phosphonic acid;hydrobromide is a S1P1 antagonist with Ki of 2.84 μM.