T9184 |
Compound 3344
|
2368246-78-8
|
98%
|
|
3344 is an inhibitor of KRAS-effector interactions,with an affnity of 126nm.
|
T2014 |
CCG-1423
|
285986-88-1
|
99.98%
|
|
CCG-1423, a selective RhoA pathway inhibitor, suppresses SRF-mediated transcription.
|
T8870 |
1-(4-methansulfinylphenyl)ethanone
|
32361-73-2
|
99.95%
|
|
The compound inhibits Ras function and therefore inhibits the abnormal growth of cells.
|
T8756 |
KRAS inhibitor-9
|
300809-71-6
|
99.94%
|
|
KRAS inhibitor-9 (DUN09716) is a potent KRAS inhibitor with Kd of 92 μM that blocks the formation of GTP-KRAS and downstream activation of KRAS. KRAS inhibitor-9...
|
T30778 |
CCG-257081
|
1922098-90-5
|
99.92%
|
|
CCG-257081 (MRTF/SRF-IN-1) is an inhibitor of cardiac myosin-related transcription factor and serum response factor (MRTF/SRF) that acts by inhibiting the Rho/MR...
|
T9184L |
Compound 3344 hydrochloride
|
T9184L
|
99.89%
|
|
Compound 3344 hydrochloride is an inhibitor of KRAS-effector interactions,with an affnity of 126nm.
|
T22062 |
CCG-100602
|
1207113-88-9
|
99.86%
|
|
CCG-100602 inhibits RhoA/C-mediated, SRF-driven luciferase expression in PC-3 prostate cancer cells (IC50 :9.8 μM).
|
T3971 |
CASIN
|
425399-05-9
|
99.86%
|
|
CASIN (Pirl1-related Compound 2) is a specific inhibitor of GTPase Cdc42 (IC50: 2 uM).
|
T6634 |
RBC8
|
361185-42-4
|
99.81%
|
|
RBC8 is a specific GTPases RalA/RalB inhibitor by inhibiting the binding of Ral to its effector RALBP1, no inhibition on the GTPases RhoA and Ras.
|
T2463 |
ML141
|
71203-35-5
|
99.77%
|
|
ML141 (CID-2950007) is an effective, specific and reversible non-competitive inhibitor of Rho family GTPase cdc42 (IC50: 200 nM).
|
T15485 |
HJC0197
|
1383539-73-8
|
99.76%
|
|
HJC0197 selectively blocks cAMP-induced Epac activation. HJC0197 is an effective exchange protein. Which straightly activated by cAMP (Epac) antagonist (IC50=5.9...
|
T8006 |
Oncrasin-1
|
75629-57-1
|
99.68%
|
|
Oncrasin 1 is a potent inhibitor of anticancer that kills various human lung cancer cells with K-Ras mutations at low or submicromolar concentrations
|
T22106 |
MLS-573151
|
10179-57-4
|
99.64%
|
|
MLS-573151 is a selective inhibitor of GTPase Cdc42(EC50 of 2 μM). It is inactive against other GTPases family members, such as Rab2, Rab7, H-Ras, Rac1, Rac 2 ...
|
T8930 |
CID44216842
|
1222513-26-9
|
99.63%
|
|
CID44216842 (KUC103479N-02) is a potent Cdc42-selective guanine nucleotide binding lead inhibitor. The EC50s for Cdc42 WT and Cdc42Q61L mutant are 1.0 and 1.2 μM...
|
T0679 |
Ketoconazole
|
65277-42-1
|
99.62%
|
|
Ketoconazole (R-41400), a CYP3A4 inhibitor, is an imidazole anti-fungal agent.
|
TN1413 |
Atranorin
|
479-20-9
|
99.57%
|
|
Atranorin shows significant antinociceptive and antiinflammatory activities, it has a relevant redox-active action, acting as a pro-oxidant or antioxidant agent ...
|
T4619 |
ML-098
|
878978-76-8
|
99.52%
|
|
ML-098 (CID-7345532) is an activator of the GTP-binding protein Rab7 (EC50: 77.6 nM).
|
T22991 |
ML-099
|
496775-95-2
|
99.48%
|
|
pan activator of Ras-related GTPases
|
T6555 |
K-Ras(G12C) inhibitor 12
|
1469337-95-8
|
99.44%
|
|
K-Ras(G12C) inhibitor 12 is an allosteric inhibitor of oncogenic K-Ras(G12C).
|
T72062 |
BI-2865
|
2937327-93-8
|
99.39%
|
|
BI-2865 is a non-covalent pan-KRAS inhibitor.BI-2865 binds to KRAS WT, G12C, G12D, G12V, and G13D mutants with KD values of 6.9, 4.5, 32, 26, and 4.3 nM, respect...
|