ROCK

Rho-associated protein kinase (ROCK) is a kinase belonging to the AGC (PKA/ PKG/PKC) family of serine-threonine kinases. It is involved mainly in regulating the shape and movement of cells by acting on the cytoskeleton.

Cat. No.	Product name	CAS No.	Purity
T14989	CMPD101	865608-11-3	99.01%
T14989	CMPD101 is a membrane-permeable small-molecule inhibitor of GRK2/3 (IC50: 18 nM and 5.4 nM). Which can be used for the study of heart failure. CMPD101 exhibits ...
T2482	AT13148	1056901-62-2	99%
T2482	AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.
T22037	AS 1892802	928320-12-1	98.9%
T22037	AS 1892802 is a potent and selective inhibitor of ROCK. AS 1892802 exibits IC50 values of 52nM, 57nM and 122 nM for human ROCK2, rat ROCK2 and human ROCK1, respe...
T1725	Y-27632 dihydrochloride	129830-38-2	98.80%
T1725	Y-27632 dihydrochloride (Y-27632 2HCl) is an orally potent, ATP-competitive inhibitor of ROCK-I and ROCK-II. Y-27632 dihydrochloride also inhibits isolation-indu...
T7764	CCG-222740	1922098-69-8	98.79%
T7764	CCG-222740 is an inhibitor of Rho/MRTF pathway
T4276L	Hydroxyfasudil	105628-72-6	98.79%
T4276L	Hydroxyfasudil (Hydroxy-Fasudil) is a ROCK inhibitor(IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively).
T2155	Thiazovivin	1226056-71-8	98.75%
T2155	Thiazovivin, a ROCK inhibitor (IC50: 0.5 μM), increases the survival rate of hESC.
T3518	GSK269962A	850664-21-0	98.63%
T3518	GSK269962A (GSK269962A HCl) is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.
T4488	GSK-25	874119-56-9	98.59%
T4488	GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC50 of 398 nM, p70S6K IC50 of 1000nM), and a dramatically impr...
T11402L	GKI-1 HCl	T11402L	98.44%
T11402L	GKI-1 HCl is a Greatwall (GWL) kinase inhibitor that inhibits hGWLFL and hGWL-KinDom.The inhibitory effect of GKI-1 HCl on ROCK1 is more significant.
T2633	GSK429286A	864082-47-3	98.42%
T2633	GSK429286A (RHO-15) is a specific inhibitor of ROCK1/2 (IC50: 14/63 nM).
T35328	H-1152 dihydrochloride	871543-07-6	98.42%
T35328	H-1152 dihydrochloride (H-1152 2HCl) is a specific inhibitor of Rho-associated protein kinase (ROCK) with an IC50 of 12 nM and a Ki of 1.6 nM. H-1152 dihydrochlo...
T15798	LX7101	1192189-69-7	98.42%
T15798	LX7101 is an effective inhibitor of LIMK and ROCK2 (IC50: 24, 1.6, and 10 nM for LIMK1, LIMK2, and ROCK2, respectively). It also inhibits PKA (IC50 <1 nM).
T38654	Cotosudil	1258833-31-6	98.41%
T38654	Cotosudil is a ROCK kinase inhibitor with antihypertensive activity and is used to treat or prevent diseases or conditions caused by cataracts, cardiovascular or...
T26078	Rhodblock 6	886625-06-5	98.27%
T26078	Rhodblock 6 is a Rho kinase (ROCK) inhibitor that inhibits the localization of phosphorylated MRLC (Myosin Regulatory Light Chain) and acts by specifically inhib...
T3513	GSK180736A	817194-38-0	98.16%
T3513	GSK180736A is an effective and selective GRK2 inhibitor (IC50: 0.77 μM) and >100-fold selectivity over other GRKs. It is a weak inhibitor of PKA (IC50: 30 μM), b...
T77609	WAY-656935	852902-81-9	98.1%
T77609	WAY-656935 inhibits ROCK.
T23308	SAR407899 hydrochloride	923262-96-8	98.01%
T23308	ATP-competitive ROCK inhibitor
T7301	BDP5290	1817698-21-7	98%
T7301	BDP5290 is a potent inhibitor of both ROCK and MRCK(IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively.)
TQ0110	ROCK-IN-2	867017-68-3	97.59%
TQ0110	ROCK-IN-2 (Azaindole 1) is a selective and ATP-competitive ROCK inhibitor with IC50 of 0.6 and 1.1 nM for human ROCK-1 and ROCK-2.