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ROCK

Rho-associated protein kinase (ROCK) is a kinase belonging to the AGC (PKA/ PKG/PKC) family of serine-threonine kinases. It is involved mainly in regulating the shape and movement of cells by acting on the cytoskeleton.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T12746 ROCK inhibitor-2 1127308-52-4 99.87%
ROCK inhibitor-2
ROCK inhibitor-2 is a selective dual inhibitor of ROCK1 and ROCK2 (IC50s of 17 nM and 2 nM, respectively).
T1870 Y-27632 146986-50-7 99.87%
Y-27632
Y-27632 dihydrochloride (Y-27632 2HCl) is an orally potent, ATP-competitive inhibitor of ROCK-I and ROCK-II. Y-27632 dihydrochloride also inhibits isolation-indu...
T4276 Hydroxyfasudil Hydrochloride 155558-32-0 99.82%
Hydroxyfasudil Hydrochloride
Hydroxyfasudil Hydrochloride (HA 1100 hydrochloride) is a ROCK1/2 inhibitor (IC50s: 0.73/0.72 μM).
T4095 ZINC00881524 557782-81-7 99.8%
ZINC00881524
ZINC00881524 (ROCK inhibitor) is an effective and specific ROCK inhibitor.
T1911 Afuresertib 1047644-62-1 99.77%
Afuresertib
Afuresertib (GSK2110183) is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity...
T6321 Tofacitinib 477600-75-2 99.74%
Tofacitinib
Tofacitinib (Tasocitinib) is an oral, small molecule inhibitor of Janus kinases that is used to treat moderate-to-severe rheumatoid arthritis.
T60924 Verosudil 1414854-42-4 99.72%
Verosudil
Verosudil (AR-12286) is a highly potent Rho kinase (ROCK) inhibitor with a Ki of 2 and 2 nM against ROCK1 and ROCK2, respectively. AR-12286 reverses steroid-indu...
TQ0183 Narciclasine 29477-83-6 99.58%
Narciclasine
Narciclasine (Lycoricidinol), a natural product, modulates the Rho/Rho-kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity.
T23888 CID-5056270 681173-76-2 99.57%
CID-5056270
CID-5056270 has anticancer activity and can inhibit lung cancer, anal cancer, bladder cancer, cervical cancer, vulvar cancer, penile cancer, Burkitt's lymphoma, ...
T1898 RKI-1447 1342278-01-6 99.56%
RKI-1447
RKI-1447 is a potent inhibitor of ROCK1 and ROCK2. It has anti-invasive and antitumor activities.
T12721 Rho-Kinase-IN-1 1035094-83-7 99.51%
Rho-Kinase-IN-1
Rho-Kinase-IN-1 is an inhibitor of ROCK with Kis of 30.5 nM and 3.9 nM for ROCK1 and ROCK2, respectively. Rho-Kinase-IN-1 can be used in studies about excessive ...
T13384L Y-33075 dihydrochloride 173897-44-4 99.43%
Y-33075 dihydrochloride
Y-33075 dihydrochloride is a selective inhibitor of ROCK(IC50 of 3.6 nM).
T14960 Chroman 1 1273579-40-0 99.28%
Chroman 1
Chroman 1 is an inhibitor of ROCK2 (IC50: 1 nM).
T2011 RKI1313 1342276-76-9 99.06%
RKI1313
RKI1313 (RKI-1313) was a selective inhibitor for ROCK-dependent signaling, cytoskeletal changes, anchorage-independent colony formation, migration, and invasion....
T36196 CAY10746 2247240-76-0 99.04%
CAY10746
CAY10746 is a selective Rho kinase (ROCK) inhibitor that inhibits ROCK I and ROCK II with IC50 values of 0.014 μM and 0.003 μM, respectively.CAY10746 can be used...
T67748 ROCK-IN-5 692870-25-0 99.03%
ROCK-IN-5
ROCK-IN-5 (compound I-B-37) is a potent inhibitor of protein kinases, including ROCK, ERK, GSK, and AGC. ROCK-IN-5 exhibits the potential for cardiac, proliferat...
T2482 AT13148 1056901-62-2 99%
AT13148
AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.
T22037 AS 1892802 928320-12-1 98.9%
AS 1892802
AS 1892802 is a potent and selective inhibitor of ROCK. AS 1892802 exibits IC50 values of 52nM, 57nM and 122 nM for human ROCK2, rat ROCK2 and human ROCK1, respe...
T1725 Y-27632 dihydrochloride 129830-38-2 98.80%
Y-27632 dihydrochloride
Y-27632 dihydrochloride (Y-27632 2HCl) is an orally potent, ATP-competitive inhibitor of ROCK-I and ROCK-II. Y-27632 dihydrochloride also inhibits isolation-indu...
T7764 CCG-222740 1922098-69-8 98.79%
CCG-222740
CCG-222740 is an inhibitor of Rho/MRTF pathway
ROCK inhibitor-2
T12746
ROCK inhibitor-2 is a selective dual inhibitor of ROCK1 and ROCK2 (IC50s of 17 nM and 2 nM, respectively).
Y-27632
T1870
Y-27632 dihydrochloride (Y-27632 2HCl) is an orally potent, ATP-competitive inhibitor of ROCK-I and ROCK-II. Y-27632 dihydrochloride also inhibits isolation-indu...
Hydroxyfasudil Hydrochloride
T4276
Hydroxyfasudil Hydrochloride (HA 1100 hydrochloride) is a ROCK1/2 inhibitor (IC50s: 0.73/0.72 μM).
ZINC00881524
T4095
ZINC00881524 (ROCK inhibitor) is an effective and specific ROCK inhibitor.
Afuresertib
T1911
Afuresertib (GSK2110183) is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity...
Tofacitinib
T6321
Tofacitinib (Tasocitinib) is an oral, small molecule inhibitor of Janus kinases that is used to treat moderate-to-severe rheumatoid arthritis.
Verosudil
T60924
Verosudil (AR-12286) is a highly potent Rho kinase (ROCK) inhibitor with a Ki of 2 and 2 nM against ROCK1 and ROCK2, respectively. AR-12286 reverses steroid-indu...
Narciclasine
TQ0183
Narciclasine (Lycoricidinol), a natural product, modulates the Rho/Rho-kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity.
CID-5056270
T23888
CID-5056270 has anticancer activity and can inhibit lung cancer, anal cancer, bladder cancer, cervical cancer, vulvar cancer, penile cancer, Burkitt's lymphoma, ...
RKI-1447
T1898
RKI-1447 is a potent inhibitor of ROCK1 and ROCK2. It has anti-invasive and antitumor activities.
Rho-Kinase-IN-1
T12721
Rho-Kinase-IN-1 is an inhibitor of ROCK with Kis of 30.5 nM and 3.9 nM for ROCK1 and ROCK2, respectively. Rho-Kinase-IN-1 can be used in studies about excessive ...
Y-33075 dihydrochloride
T13384L
Y-33075 dihydrochloride is a selective inhibitor of ROCK(IC50 of 3.6 nM).
Chroman 1
T14960
Chroman 1 is an inhibitor of ROCK2 (IC50: 1 nM).
RKI1313
T2011
RKI1313 (RKI-1313) was a selective inhibitor for ROCK-dependent signaling, cytoskeletal changes, anchorage-independent colony formation, migration, and invasion....
CAY10746
T36196
CAY10746 is a selective Rho kinase (ROCK) inhibitor that inhibits ROCK I and ROCK II with IC50 values of 0.014 μM and 0.003 μM, respectively.CAY10746 can be used...
ROCK-IN-5
T67748
ROCK-IN-5 (compound I-B-37) is a potent inhibitor of protein kinases, including ROCK, ERK, GSK, and AGC. ROCK-IN-5 exhibits the potential for cardiac, proliferat...
AT13148
T2482
AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.
AS 1892802
T22037
AS 1892802 is a potent and selective inhibitor of ROCK. AS 1892802 exibits IC50 values of 52nM, 57nM and 122 nM for human ROCK2, rat ROCK2 and human ROCK1, respe...
Y-27632 dihydrochloride
T1725
Y-27632 dihydrochloride (Y-27632 2HCl) is an orally potent, ATP-competitive inhibitor of ROCK-I and ROCK-II. Y-27632 dihydrochloride also inhibits isolation-indu...
CCG-222740
T7764
CCG-222740 is an inhibitor of Rho/MRTF pathway
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TargetMol