T12746 |
ROCK inhibitor-2
|
1127308-52-4
|
99.87%
|
|
ROCK inhibitor-2 is a selective dual inhibitor of ROCK1 and ROCK2 (IC50s of 17 nM and 2 nM, respectively).
|
T1870 |
Y-27632
|
146986-50-7
|
99.87%
|
|
Y-27632 dihydrochloride (Y-27632 2HCl) is an orally potent, ATP-competitive inhibitor of ROCK-I and ROCK-II. Y-27632 dihydrochloride also inhibits isolation-indu...
|
T4276 |
Hydroxyfasudil Hydrochloride
|
155558-32-0
|
99.82%
|
|
Hydroxyfasudil Hydrochloride (HA 1100 hydrochloride) is a ROCK1/2 inhibitor (IC50s: 0.73/0.72 μM).
|
T4095 |
ZINC00881524
|
557782-81-7
|
99.8%
|
|
ZINC00881524 (ROCK inhibitor) is an effective and specific ROCK inhibitor.
|
T1911 |
Afuresertib
|
1047644-62-1
|
99.77%
|
|
Afuresertib (GSK2110183) is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity...
|
T6321 |
Tofacitinib
|
477600-75-2
|
99.74%
|
|
Tofacitinib (Tasocitinib) is an oral, small molecule inhibitor of Janus kinases that is used to treat moderate-to-severe rheumatoid arthritis.
|
T60924 |
Verosudil
|
1414854-42-4
|
99.72%
|
|
Verosudil (AR-12286) is a highly potent Rho kinase (ROCK) inhibitor with a Ki of 2 and 2 nM against ROCK1 and ROCK2, respectively. AR-12286 reverses steroid-indu...
|
TQ0183 |
Narciclasine
|
29477-83-6
|
99.58%
|
|
Narciclasine (Lycoricidinol), a natural product, modulates the Rho/Rho-kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity.
|
T23888 |
CID-5056270
|
681173-76-2
|
99.57%
|
|
CID-5056270 has anticancer activity and can inhibit lung cancer, anal cancer, bladder cancer, cervical cancer, vulvar cancer, penile cancer, Burkitt's lymphoma, ...
|
T1898 |
RKI-1447
|
1342278-01-6
|
99.56%
|
|
RKI-1447 is a potent inhibitor of ROCK1 and ROCK2. It has anti-invasive and antitumor activities.
|
T12721 |
Rho-Kinase-IN-1
|
1035094-83-7
|
99.51%
|
|
Rho-Kinase-IN-1 is an inhibitor of ROCK with Kis of 30.5 nM and 3.9 nM for ROCK1 and ROCK2, respectively. Rho-Kinase-IN-1 can be used in studies about excessive ...
|
T13384L |
Y-33075 dihydrochloride
|
173897-44-4
|
99.43%
|
|
Y-33075 dihydrochloride is a selective inhibitor of ROCK(IC50 of 3.6 nM).
|
T14960 |
Chroman 1
|
1273579-40-0
|
99.28%
|
|
Chroman 1 is an inhibitor of ROCK2 (IC50: 1 nM).
|
T2011 |
RKI1313
|
1342276-76-9
|
99.06%
|
|
RKI1313 (RKI-1313) was a selective inhibitor for ROCK-dependent signaling, cytoskeletal changes, anchorage-independent colony formation, migration, and invasion....
|
T36196 |
CAY10746
|
2247240-76-0
|
99.04%
|
|
CAY10746 is a selective Rho kinase (ROCK) inhibitor that inhibits ROCK I and ROCK II with IC50 values of 0.014 μM and 0.003 μM, respectively.CAY10746 can be used...
|
T67748 |
ROCK-IN-5
|
692870-25-0
|
99.03%
|
|
ROCK-IN-5 (compound I-B-37) is a potent inhibitor of protein kinases, including ROCK, ERK, GSK, and AGC. ROCK-IN-5 exhibits the potential for cardiac, proliferat...
|
T2482 |
AT13148
|
1056901-62-2
|
99%
|
|
AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.
|
T22037 |
AS 1892802
|
928320-12-1
|
98.9%
|
|
AS 1892802 is a potent and selective inhibitor of ROCK. AS 1892802 exibits IC50 values of 52nM, 57nM and 122 nM for human ROCK2, rat ROCK2 and human ROCK1, respe...
|
T1725 |
Y-27632 dihydrochloride
|
129830-38-2
|
98.80%
|
|
Y-27632 dihydrochloride (Y-27632 2HCl) is an orally potent, ATP-competitive inhibitor of ROCK-I and ROCK-II. Y-27632 dihydrochloride also inhibits isolation-indu...
|
T7764 |
CCG-222740
|
1922098-69-8
|
98.79%
|
|
CCG-222740 is an inhibitor of Rho/MRTF pathway
|