RIP kinase

RIP kinases (receptor-interacting protein kinases) are a class of serine/threonine protein kinases. In humans, five different RIP kinases are known:RIPK1,RIPK2,RIPK3,RIPK4,RIPK5.

Cat. No.	Product name	CAS No.	Purity
T61424	OD36 hydrochloride	2387510-88-3	99.85%
T61424	OD36 hydrochloride (OD-36 hydrochloride) is a potent RIPK2 inhibitor with an IC50 of 5.3 nM.OD36 hydrochloride is a macrocyclic inhibitor that binds efficiently ...
T3997	WEHI-345	1354825-58-3
T3997	WEHI-345 is a potent and selective RIPK2 inhibitor which shows NOD signalling events yet prevents inflammatory cytokine production.
T78597	RIPK2-IN-3	1290490-78-6	98%
T78597	RIPK2-IN-3 (FCG806791773) is a receptor-interacting protein kinase 2 (RIPK2) inhibitor with an IC50 value of 6.39 μM against recombinant truncated RIPK2. It is a...
T79041	RIP1 kinase inhibitor 4	2919836-00-1	98%
T79041	RIP1 Kinase Inhibitor 4 (Compound 3) is an effective inhibitor of RIP1K, exhibiting an EC50 of ≤ 1000 nM [1].
T79042	RIP1 kinase inhibitor 5	2428422-17-5	98%
T79042	RIP1 kinase inhibitor 5 (example 1) serves as a potent regulator of tumor immunity by inhibiting RIP1, functioning similarly to SIR1-365 (compound 13) in suppres...
T79043	RIP1 kinase inhibitor 6	2428401-62-9	98%
T79043	RIP1 Kinase Inhibitor 6 is a potent and selective inhibitor of RIP1 kinase, demonstrating inhibitory activity with an IC50 of less than 100 nM in a human R1P1 ki...
T79044	RIP1 kinase inhibitor 7	2428401-23-2	98%
T79044	RIP1 Kinase Inhibitor 7 (Compound 41) serves as a potent inhibitory agent for receptor interacting protein 1 kinase (RIP1) with an IC50 of under 100 nM. Addition...
T79352	RIPK2/3-IN-1		98%
T79352	RIPK2/3-IN-1 is a potent inhibitor of both RIPK2 and RIPK3 kinases, exhibiting IC50 values of 3 nM for RIPK2 and 117 nM for RIPK3. Additionally, in a 14-TriLAN-G...
T81267	RIPK3-IN-4	2304617-58-9	98%
T81267	RIPK3-IN-4 (Compound 42) is a RIPK3 inhibitor that mitigates necroptosis, inflammatory responses, and HK-2 cell damage. It alleviates acute kidney injury by atte...
T81268	RIPK1-IN-17		98%
T81268	RIPK1/3-IN-1 (Compound 10) is a selective inhibitor of both RIPK1 and RIPK3, effectively preventing necroptosis by blocking the phosphorylation of RIPK1, RIPK3, ...
T81269	RIPK1-IN-16	2561431-77-2	98%
T81269	RIPK1-IN-16 is an orally active, potent RIPK1 inhibitor that mitigates excessive inflammation via inhibition of RIPK1-mediated necroptosis in vivo. It shields mi...
T73382	SZM-1209	2919801-86-6	98%
T73382	SZM-1209 is a potent and specific RIPK1 inhibitor with oral activity, displaying a dissociation constant (Kd) of 85 nM. It demonstrates substantial anti-necropto...
T73493	RI-962	2763831-53-2	98%
T73493	RI-962 is a potent and selective inhibitor of receptor-interacting protein kinase 1 (RIPK1), exhibiting an IC50 of 35.0 nM. It is utilized for the investigation ...
T73511	SZM679	T73511	98%
T73511	SZM679 is an orally active, selective RIPK1 inhibitor displaying potent affinity with a dissociation constant (Kd) of 8.6 nM for RIPK1, while exhibiting minimal ...
T4074L	GSK872 HCl（1346546-69-7 free base）	2703752-81-0	99.82%
T4074L	GSK872 HCl（1346546-69-7 free base） (GSK2399872A) is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain with high affinity (IC50: 1.8 nM...
T1847	Necrostatin-1	4311-88-0	99.74%
T1847	Necrostatin-1 (Nec-1) is a necrotic apoptosis inhibitor and RIP1 inhibitor with specificity. Necrostatin-1 inhibits TNF-α-induced necrotic apoptosis. Necrostatin...
T6852	GSK481	1622849-58-4	99.71%
T6852	GSK481 (GSK'481) is a RIP1(Receptor Interacting Protein Kinase1) inhibitor. Inhibition of RIP1 has been shown to hinder cell necrotic death.
T7504	Necrostatin 2 racemate	852391-15-2	99.69%
T7504	Necrostatin 2 racemate (Necrostatin-2 racemate) is an potent and specific inhibitor of RIPK1.
T12730	RIPK1-IN-4	1481641-08-0	99.66%
T12730	RIPK1-IN-4 is a potent and selective type II kinase receptor interacting protein 1 (RIP1) kinase inhibitor and binds to a DLG-out inactive form of RIP1 (IC50s of...
T2048	LY-364947	396129-53-6	99.65%
T2048	LY-364947 (HTS466284) is a potent ATP-competitive inhibitor of TGFβR-I.