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Proteasome

Proteasomes are protein complexes which degrade unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Enzymes that help such reactions are called proteases.Proteasomes are part of a major mechanism by which cells regulate the concentration of particular proteins and degrade misfolded proteins.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T12628 (R)-MG-132 1211877-36-9 98.45%
(R)-MG-132
(R)-MG-132 (Z-Leu-D-leu-leu-al) is the enantiomer of MG-132. (R)-MG-132 stereoisomer is a more potent proteasome inhibitor than MG-132.
T3786 Tomatine 17406-45-0 98.42%
Tomatine
Tomatine (lycopersicin) is an antiproliferatve agent of breast adenocarcinoma cells.
T8397 Ixazomib citrate 1239908-20-3 98.37%
Ixazomib citrate
Ixazomib citrate (MLN9708) is a prodrug of Ixazomib (MMLN-2238). MLN9708 is an orally bioavailable second generation proteasome inhibitor (IC50 of 3.4 nM ) with ...
T10061 (1S,2S)-Bortezomib 1132709-14-8 98.33%
(1S,2S)-Bortezomib
(1S,2S)-Bortezomib (Bortezomib) is an enantiomer of Bortezomib. Bortezomib is a reversible and selective inhibitor of the proteasome with a Ki of 0.6 nM for 20S ...
T14005 1G244 847928-32-9 98.23%
1G244
1G244 is an inhibitor of DPP8/9 with antiatherosclerotic and antimyeloma properties. 1G244 had the IC50 values of 14 and 53 nM against DPP8 and DPP9, and The Ki ...
T39214L LXE408 fumarate 98.10%
LXE408 fumarate
LXE408 fumarate is an orally active, non-competitive and kinetoplastid-selective proteasome inhibitor. LXE408 fumarate has an IC50 of 0.04 μM for L. donovani pro...
T2122 Ixazomib 1072833-77-2 98.07%
Ixazomib
Ixazomib (MLN2238) , a second generation, boron-containing peptide proteasome inhibitor (PI), inhibits the chymotrypsin-like proteolytic (β5) site of the 20S pro...
T2016 MLN9708 1201902-80-8 98%
MLN9708
MLN2238 suppresses the chymotrypsin-like proteolytic (β5) site of the 20S proteasome(Ki50=0.93 nM, IC50=3.4 nM/). The biologically active form of MLN9708 (Ixazom...
T6583 MG-101 110044-82-1 98%
MG-101
MG-101 (Calpain inhibitor I) is a cell-permeable and potent inhibitor of cysteine proteases including calpains and lysosomal cathepsins.
T1502 Vildagliptin 274901-16-5 98%
Vildagliptin
Vildagliptin (LAF237) is a cyanopyrrolidine-based, orally bioavailable inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity. Vildagliptin's cy...
TN1262 3-Feruloylquinic acid 1899-29-2 97.83%
3-Feruloylquinic acid
3-O-Feruloylquinic acid is a protease inhibitor, it exerts moderate inhibitory effect against AIV (H5N1) in vitro.
T13858 RA190 1617495-03-0 97.69%
RA190
RA190 inhibits proteasome function by covalently binding to cysteine 88 of ubiquitin receptor RPN13.
T7854 Bortezomib-pinanediol 205393-22-2 97.5%
Bortezomib-pinanediol
Bortezomib-pinanediol is a proteasome inhibitor. is a prodrug of Bortezomib.
T16169 N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride 4272-74-6 97.44%
N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride
N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride (N-alpha-Tosyl-L-lysine_chloromethyl_ketone_hydrochloride) is an inhibitor of trypsin-like protease. N-a...
T67852 Linagliptin Methyldimer 1418133-47-7 97.23%
Linagliptin Methyldimer
Linagliptin Methyldimer is a potent dipeptidyl peptidase IV inhibitor, IC50=6 pM.
T21617 MG-115 133407-86-0 97.12%
MG-115
MG-115 (Z-LL-Nva-CHO) is a potent and reversible inhibitor of proteasome , with K i s of 21 nM and 35 nM for 20S and 26S proteasome, respectively. MG-115 specifi...
T8350 TPCK 402-71-1 96.77%
TPCK
TPCK is an irreversible inhibitor of chymotrypsin-like proteases that affect cell proliferation, apoptosis, and tumorigenesis
T2154 MG-132 133407-82-6 95.91%
MG-132
MG-132 (Z-Leu-Leu-Leu-al) is a 26S proteasome inhibitor (IC50=100 nM) that is cell-permeable and reversible. MG-132 acts as an autophagy activator and also induc...
T12079 ML604440 1140517-08-3 95.24%
ML604440
ML604440 is a cell permeable proteasome β1i (LMP2) subunit inhibitor.
T6999 Teneligliptin hydrobromide 906093-29-6 100%
Teneligliptin hydrobromide
Teneligliptin hydrobromide (MP-513 (hydrobromide)) is a novel, potent, and long-lasting dipeptidyl peptidase-4 inhibitor; competitively inhibited human plasma, r...
(R)-MG-132
T12628
(R)-MG-132 (Z-Leu-D-leu-leu-al) is the enantiomer of MG-132. (R)-MG-132 stereoisomer is a more potent proteasome inhibitor than MG-132.
Tomatine
T3786
Tomatine (lycopersicin) is an antiproliferatve agent of breast adenocarcinoma cells.
Ixazomib citrate
T8397
Ixazomib citrate (MLN9708) is a prodrug of Ixazomib (MMLN-2238). MLN9708 is an orally bioavailable second generation proteasome inhibitor (IC50 of 3.4 nM ) with ...
(1S,2S)-Bortezomib
T10061
(1S,2S)-Bortezomib (Bortezomib) is an enantiomer of Bortezomib. Bortezomib is a reversible and selective inhibitor of the proteasome with a Ki of 0.6 nM for 20S ...
1G244
T14005
1G244 is an inhibitor of DPP8/9 with antiatherosclerotic and antimyeloma properties. 1G244 had the IC50 values of 14 and 53 nM against DPP8 and DPP9, and The Ki ...
LXE408 fumarate
T39214L
LXE408 fumarate is an orally active, non-competitive and kinetoplastid-selective proteasome inhibitor. LXE408 fumarate has an IC50 of 0.04 μM for L. donovani pro...
Ixazomib
T2122
Ixazomib (MLN2238) , a second generation, boron-containing peptide proteasome inhibitor (PI), inhibits the chymotrypsin-like proteolytic (β5) site of the 20S pro...
MLN9708
T2016
MLN2238 suppresses the chymotrypsin-like proteolytic (β5) site of the 20S proteasome(Ki50=0.93 nM, IC50=3.4 nM/). The biologically active form of MLN9708 (Ixazom...
MG-101
T6583
MG-101 (Calpain inhibitor I) is a cell-permeable and potent inhibitor of cysteine proteases including calpains and lysosomal cathepsins.
Vildagliptin
T1502
Vildagliptin (LAF237) is a cyanopyrrolidine-based, orally bioavailable inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity. Vildagliptin's cy...
3-Feruloylquinic acid
TN1262
3-O-Feruloylquinic acid is a protease inhibitor, it exerts moderate inhibitory effect against AIV (H5N1) in vitro.
RA190
T13858
RA190 inhibits proteasome function by covalently binding to cysteine 88 of ubiquitin receptor RPN13.
Bortezomib-pinanediol
T7854
Bortezomib-pinanediol is a proteasome inhibitor. is a prodrug of Bortezomib.
N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride
T16169
N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride (N-alpha-Tosyl-L-lysine_chloromethyl_ketone_hydrochloride) is an inhibitor of trypsin-like protease. N-a...
Linagliptin Methyldimer
T67852
Linagliptin Methyldimer is a potent dipeptidyl peptidase IV inhibitor, IC50=6 pM.
MG-115
T21617
MG-115 (Z-LL-Nva-CHO) is a potent and reversible inhibitor of proteasome , with K i s of 21 nM and 35 nM for 20S and 26S proteasome, respectively. MG-115 specifi...
TPCK
T8350
TPCK is an irreversible inhibitor of chymotrypsin-like proteases that affect cell proliferation, apoptosis, and tumorigenesis
MG-132
T2154
MG-132 (Z-Leu-Leu-Leu-al) is a 26S proteasome inhibitor (IC50=100 nM) that is cell-permeable and reversible. MG-132 acts as an autophagy activator and also induc...
ML604440
T12079
ML604440 is a cell permeable proteasome β1i (LMP2) subunit inhibitor.
Teneligliptin hydrobromide
T6999
Teneligliptin hydrobromide (MP-513 (hydrobromide)) is a novel, potent, and long-lasting dipeptidyl peptidase-4 inhibitor; competitively inhibited human plasma, r...
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TargetMol