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Proteasome

Proteasomes are protein complexes which degrade unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Enzymes that help such reactions are called proteases.Proteasomes are part of a major mechanism by which cells regulate the concentration of particular proteins and degrade misfolded proteins.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T16568 PR-924 1416709-79-9 98%
PR-924
PR-924 is a selective inhibitor of tripeptide epoxyketone immunoproteasome subunit LMP-7 (IC50: 22 nM). PR-924 inhibits growth and triggers apoptosis in multiple...
T78625 Z-Ala-Arg-Arg-AMC 90468-18-1 98%
Z-Ala-Arg-Arg-AMC
Z-Ala-Arg-Arg-AMC (Fluorogenic Proteasome Substrate) serves as a fluorogenic substrate designed to assay the trypsin-like activity within the proteasome [1].
T78632 Z-LLY-FMK 133410-84-1 98%
Z-LLY-FMK
Z-LLY-FMK (Calpain Inhibitor IV) serves as an inhibitor of calpain, a family of proteases implicated in the apoptosis of various cell systems. Specifically, this...
T78640 Z-LLF-CHO 133429-58-0 98%
Z-LLF-CHO
Z-LLF-CHO (Z-Leu-Leu-Phe-CHO) effectively inhibits the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex with a Ki value of 460 nM. A...
T79316 Antitrypanosomal agent 15 98%
Antitrypanosomal agent 15
Antitrypanosomal Agent 15 (Compound 26) is an orally active, brain-penetrant, selective inhibitor of the Trypanosoma cruzi proteasome, exhibiting a pIC50 of 7.4 ...
T79842 Davelizomib 2409841-51-4 98%
Davelizomib
Davelizomib is a proteasome inhibitor that exhibits antineoplastic activity [1].
T80101 Z-GGF-CMK 35172-59-9 98%
Z-GGF-CMK
Z-GGF-CMK, a protease inhibitor, impedes ClpP1P2 and proteasome activity and demonstrates cytotoxic effects on HepG2 cells, with a CC50 value of 125 μM [1].
T80102 Z-Leu-Leu-Tyr-COCHO 204649-66-1 98%
Z-Leu-Leu-Tyr-COCHO
Z-Leu-Leu-Tyr-COCHO is a potent inhibitor of chymotrypsin-like activity, exhibiting a Ki value of 3.0 nM [1].
T80129 Baceridin 1622872-91-6 98%
Baceridin
Baceridin, a cyclic hexapeptide and proteasome inhibitor, can be isolated from the culture medium of Epiphytic Bacillus. It has the ability to impede cell cycle ...
T80241 Calpastatin subdomain B 128578-18-7 98%
Calpastatin subdomain B
Calpastatin subdomain B is a bioactive peptide that inhibits calpain activity.
T80697 β5i-IN-1 98%
β5i-IN-1
β5i-IN-1 is a selective inhibitor of β5i, exhibiting potent activity with an IC50 of 8.463 nM. It modulates immune responses by promoting the release of TNF-α an...
T80735 Z-Gly-Pro-Phe-Leu-CHO 159659-05-9 98%
Z-Gly-Pro-Phe-Leu-CHO
Z-Gly-Pro-Phe-Leu-CHO (Z-GPFL-CHO) is a tetrapeptide aldehyde serving as a selective and potent proteasome inhibitor, demonstrating inhibition constants (Ki) of ...
T81371 Proteasome-IN-5 1613134-34-1 98%
Proteasome-IN-5
Proteasome-IN-5, also known as compound 5, acts as a proteasome inhibitor [1].
T81373 Proteasome β2c/i-IN-1 2322333-75-3 98%
Proteasome β2c/i-IN-1
Proteasome β2c/i-IN-1 (compound 37) serves as a selective inhibitor targeting the β2c and β2i subunits of the human proteasome [1].
T81909 LU-002i 1838705-22-8 98%
LU-002i
LU-002i is a selective inhibitor targeting the human proteasome subunits β2c and β2i, demonstrating an inhibitory concentration (IC50) of 220 nM for β2i [1].
T12561 Proteasome-IN-1 374080-21-4 98%
Proteasome-IN-1
Proteasome-IN-1 is an inhibitor of proteasome.
T15702 Lactacystin 133343-34-7 98%
Lactacystin
Lactacystin is an antibiotic Streptomyces spp. the metabolite and is an effective and selective proteasome inhibitor (IC50: 4.8 μM for 20S proteasome). Lactacyst...
T10238 Aclacinomycin A hydrochloride 75443-99-1 98%
Aclacinomycin A hydrochloride
Aclacinomycin A (Aclarubicin) hydrochloride is a fluorescent molecule and the first described non-peptidic inhibitor showing discrete specificity for the CTRL (c...
T11924 M3258 2285330-15-4 98%
M3258
LMP7-IN-1 may used in the research of inflammatory and autoimmune diseases, neurodegenerative diseases, proliferative diseases and cancer, is an inhibitor of imm...
T15678 KZR-504 1629052-78-3 98%
KZR-504
KZR-504 is a selective inhibitor of immunoproteasome low molecular mass polypeptide 2 (LMP2) (IC50s: 51 nM, 4.274 μM for LMP2 and LMP7, respectively).
PR-924
T16568
PR-924 is a selective inhibitor of tripeptide epoxyketone immunoproteasome subunit LMP-7 (IC50: 22 nM). PR-924 inhibits growth and triggers apoptosis in multiple...
Z-Ala-Arg-Arg-AMC
T78625
Z-Ala-Arg-Arg-AMC (Fluorogenic Proteasome Substrate) serves as a fluorogenic substrate designed to assay the trypsin-like activity within the proteasome [1].
Z-LLY-FMK
T78632
Z-LLY-FMK (Calpain Inhibitor IV) serves as an inhibitor of calpain, a family of proteases implicated in the apoptosis of various cell systems. Specifically, this...
Z-LLF-CHO
T78640
Z-LLF-CHO (Z-Leu-Leu-Phe-CHO) effectively inhibits the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex with a Ki value of 460 nM. A...
Antitrypanosomal agent 15
T79316
Antitrypanosomal Agent 15 (Compound 26) is an orally active, brain-penetrant, selective inhibitor of the Trypanosoma cruzi proteasome, exhibiting a pIC50 of 7.4 ...
Davelizomib
T79842
Davelizomib is a proteasome inhibitor that exhibits antineoplastic activity [1].
Z-GGF-CMK
T80101
Z-GGF-CMK, a protease inhibitor, impedes ClpP1P2 and proteasome activity and demonstrates cytotoxic effects on HepG2 cells, with a CC50 value of 125 μM [1].
Z-Leu-Leu-Tyr-COCHO
T80102
Z-Leu-Leu-Tyr-COCHO is a potent inhibitor of chymotrypsin-like activity, exhibiting a Ki value of 3.0 nM [1].
Baceridin
T80129
Baceridin, a cyclic hexapeptide and proteasome inhibitor, can be isolated from the culture medium of Epiphytic Bacillus. It has the ability to impede cell cycle ...
Calpastatin subdomain B
T80241
Calpastatin subdomain B is a bioactive peptide that inhibits calpain activity.
β5i-IN-1
T80697
β5i-IN-1 is a selective inhibitor of β5i, exhibiting potent activity with an IC50 of 8.463 nM. It modulates immune responses by promoting the release of TNF-α an...
Z-Gly-Pro-Phe-Leu-CHO
T80735
Z-Gly-Pro-Phe-Leu-CHO (Z-GPFL-CHO) is a tetrapeptide aldehyde serving as a selective and potent proteasome inhibitor, demonstrating inhibition constants (Ki) of ...
Proteasome-IN-5
T81371
Proteasome-IN-5, also known as compound 5, acts as a proteasome inhibitor [1].
Proteasome β2c/i-IN-1
T81373
Proteasome β2c/i-IN-1 (compound 37) serves as a selective inhibitor targeting the β2c and β2i subunits of the human proteasome [1].
LU-002i
T81909
LU-002i is a selective inhibitor targeting the human proteasome subunits β2c and β2i, demonstrating an inhibitory concentration (IC50) of 220 nM for β2i [1].
Proteasome-IN-1
T12561
Proteasome-IN-1 is an inhibitor of proteasome.
Lactacystin
T15702
Lactacystin is an antibiotic Streptomyces spp. the metabolite and is an effective and selective proteasome inhibitor (IC50: 4.8 μM for 20S proteasome). Lactacyst...
Aclacinomycin A hydrochloride
T10238
Aclacinomycin A (Aclarubicin) hydrochloride is a fluorescent molecule and the first described non-peptidic inhibitor showing discrete specificity for the CTRL (c...
M3258
T11924
LMP7-IN-1 may used in the research of inflammatory and autoimmune diseases, neurodegenerative diseases, proliferative diseases and cancer, is an inhibitor of imm...
KZR-504
T15678
KZR-504 is a selective inhibitor of immunoproteasome low molecular mass polypeptide 2 (LMP2) (IC50s: 51 nM, 4.274 μM for LMP2 and LMP7, respectively).
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TargetMol