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Prostaglandin Receptor

Prostaglandin receptors or prostanoid receptors represent a sub-class of cell surface membrane receptors that are regarded as the primary receptors for one or more of the classical, naturally occurring prostanoids viz., prostaglandin D2, , PGE2, PGF2alpha, prostacyclin (PGI2), thromboxane A2 (TXA2), and PGH2.[1] They are named based on the prostanoid to which they preferentially bind and respond, e.g. the receptor responsive to PGI2 at lower concentrations than any other prostanoid is named the Prostacyclin receptor (IP). One exception to this rule is the receptor for thromboxane A2 (TP) which binds and responds to PGH2 and TXA2 equally well.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T27630 Isbogrel 89667-40-3 97.06%
Isbogrel
Isbogrel (CV4151) is a small molecule thromboxane A2 synthase (TXA2 synthase) inhibitor that can be used to study cardiac arrhythmias, transient ischemic attacks...
T10960L Darbufelone mesylate 139340-56-0 96.81%
Darbufelone mesylate
Darbufelone mesylate (CI-1004 mesylate) inhibited PGF2α and LTB4 in cells. Darbufelone mesylate inhibited PGHS-2 with IC50 value of 0.19 μM and PGHS-1 with IC50 ...
T27084 Crisdesalazine 927685-43-6 95.95%
Crisdesalazine
Crisdesalazine (AAD 2004) is an inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1). Crisdesalazine reduces autophagosome formation, axonopathy, and mo...
T0795 Rutin 153-18-4 95%
Rutin
Rutin (Quercetin 3-O-rutinoside), a flavonoid, has a variety of biological activities including antiallergic, anti-inflammatory, antiproliferative, and anticarci...
T13563 AZ-1355 75451-07-9 100%
AZ-1355
AZ-1355 is a novel dibenzoxepine derivative with lipid-lowering properties.
T77699 EP4-IN-1 2455480-28-9 100%
EP4-IN-1
EP4-IN-1 is a potent prostaglandin EP4 receptor inhibitor with potential anti-tumor, anti-inflammatory and analgesic activities for the study of immune and tumor...
T2428 TG6-10-1 1415716-58-3 100%
TG6-10-1
TG6-10-1 is an EP2 antagonist.
T5841 Travoprost 157283-68-6 100%
Travoprost
Travoprost (Fluprostenol isopropyl ester) is used to treat glaucoma and ocular hypertension,is a potent and selective FP prostaglandin receptor agonist.
T36619 Aligeron 70713-45-0 100%
Aligeron
Aligeron is a non-selective prostaglandin (PG) antagonist that inhibits PGF2α- and PGE2-induced decreases in blood pressure in cats, and can be used to inhibit P...
T2538 Bimatoprost 155206-00-1 100%
Bimatoprost
Bimatoprost (AGN 192024) is a cloprostenol-derived amide that is used as an antihypertensive agent in the treatment of open-angle glaucoma and ocular hypertensio...
T6236 Ozagrel 82571-53-7 100%
Ozagrel
Ozagrel (Domenan) is a selective thromboxane A(2) (TXA(2)) synthetase inhibitor with IC50 of 11 nM for rabbit platelet, used for the improvement of postoperative...
T3915 Ginsenoside Ro 34367-04-9
Ginsenoside Ro
Ginsenoside Ro (Chikusetsusaponin V) can reduce TXA2 production, weakly reduce COX-1 and TXAS activities, and has antiplatelet effects as a Ca2+ antagonist with ...
T1338 Sucralfate 54182-58-0
Sucralfate
Sucralfate (Sucrose octasulfate–aluminum complex) is a cytoprotective agent, an oral gastrointestinal medication primarily indicated for the treatment of active ...
T7359 CAY10471 Racemate 844639-57-2
CAY10471 Racemate
CAY10471 Racemate (TM30089 Racemate) is a potent, highly selective CRTH2/DP 2 receptor antagonist. CAY10471 Racemate binds to the human CRTH2/DP2, DP1, and TP re...
T4635 Ralinepag 1187856-49-0 98%
Ralinepag
Ralinepag (APD811) is a potent, orally bioavailable agonist of non-prostanoid prostacyclin (IP) receptor, with EC50s of 8.5 nM, 530 nM and 850 nM for human and r...
TN1257 3-O-Acetyl-α-boswellic acid 89913-60-0 98%
3-O-Acetyl-α-boswellic acid
3-O-Acetyl-α-boswellic acid (α-Boswellic acid acetate) has strong anti-inflammatory activity.
T5505 Terutroban 165538-40-9 98%
Terutroban
Terutroban, a thromboxane prostaglandin receptor antagonist, affects the progression of atherosclerosis.
T23331 SC 51089 146033-02-5 98%
SC 51089
SC 51089 is a selective prostaglandin receptor PGE2 antagonist with selectivity for prostaglandin receptor subtypes and anti-injury activity that ameliorates mot...
T22285 Carboprost 35700-23-3 98%
Carboprost
Carboprost (15(S)-15-Methyl Prostaglandin F2α) is a synthetic prostaglandin analogue of PGF2α which has the effect of oxytocic. Carboprost is commonly used to re...
T17232 Vidupiprant 1169483-24-2 98%
Vidupiprant
Vidupiprant (AMG 853) is an effective dual antagonist of CRTH2 and prostanoid D receptor with IC50s of 8 nM and 35 nM in human plasma. Vidupiprant can be used in...
Isbogrel
T27630
Isbogrel (CV4151) is a small molecule thromboxane A2 synthase (TXA2 synthase) inhibitor that can be used to study cardiac arrhythmias, transient ischemic attacks...
Darbufelone mesylate
T10960L
Darbufelone mesylate (CI-1004 mesylate) inhibited PGF2α and LTB4 in cells. Darbufelone mesylate inhibited PGHS-2 with IC50 value of 0.19 μM and PGHS-1 with IC50 ...
Crisdesalazine
T27084
Crisdesalazine (AAD 2004) is an inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1). Crisdesalazine reduces autophagosome formation, axonopathy, and mo...
Rutin
T0795
Rutin (Quercetin 3-O-rutinoside), a flavonoid, has a variety of biological activities including antiallergic, anti-inflammatory, antiproliferative, and anticarci...
AZ-1355
T13563
AZ-1355 is a novel dibenzoxepine derivative with lipid-lowering properties.
EP4-IN-1
T77699
EP4-IN-1 is a potent prostaglandin EP4 receptor inhibitor with potential anti-tumor, anti-inflammatory and analgesic activities for the study of immune and tumor...
TG6-10-1
T2428
TG6-10-1 is an EP2 antagonist.
Travoprost
T5841
Travoprost (Fluprostenol isopropyl ester) is used to treat glaucoma and ocular hypertension,is a potent and selective FP prostaglandin receptor agonist.
Aligeron
T36619
Aligeron is a non-selective prostaglandin (PG) antagonist that inhibits PGF2α- and PGE2-induced decreases in blood pressure in cats, and can be used to inhibit P...
Bimatoprost
T2538
Bimatoprost (AGN 192024) is a cloprostenol-derived amide that is used as an antihypertensive agent in the treatment of open-angle glaucoma and ocular hypertensio...
Ozagrel
T6236
Ozagrel (Domenan) is a selective thromboxane A(2) (TXA(2)) synthetase inhibitor with IC50 of 11 nM for rabbit platelet, used for the improvement of postoperative...
Ginsenoside Ro
T3915
Ginsenoside Ro (Chikusetsusaponin V) can reduce TXA2 production, weakly reduce COX-1 and TXAS activities, and has antiplatelet effects as a Ca2+ antagonist with ...
Sucralfate
T1338
Sucralfate (Sucrose octasulfate–aluminum complex) is a cytoprotective agent, an oral gastrointestinal medication primarily indicated for the treatment of active ...
CAY10471 Racemate
T7359
CAY10471 Racemate (TM30089 Racemate) is a potent, highly selective CRTH2/DP 2 receptor antagonist. CAY10471 Racemate binds to the human CRTH2/DP2, DP1, and TP re...
Ralinepag
T4635
Ralinepag (APD811) is a potent, orally bioavailable agonist of non-prostanoid prostacyclin (IP) receptor, with EC50s of 8.5 nM, 530 nM and 850 nM for human and r...
3-O-Acetyl-α-boswellic acid
TN1257
3-O-Acetyl-α-boswellic acid (α-Boswellic acid acetate) has strong anti-inflammatory activity.
Terutroban
T5505
Terutroban, a thromboxane prostaglandin receptor antagonist, affects the progression of atherosclerosis.
SC 51089
T23331
SC 51089 is a selective prostaglandin receptor PGE2 antagonist with selectivity for prostaglandin receptor subtypes and anti-injury activity that ameliorates mot...
Carboprost
T22285
Carboprost (15(S)-15-Methyl Prostaglandin F2α) is a synthetic prostaglandin analogue of PGF2α which has the effect of oxytocic. Carboprost is commonly used to re...
Vidupiprant
T17232
Vidupiprant (AMG 853) is an effective dual antagonist of CRTH2 and prostanoid D receptor with IC50s of 8 nM and 35 nM in human plasma. Vidupiprant can be used in...
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TargetMol