Prostaglandin Receptor

Prostaglandin receptors or prostanoid receptors represent a sub-class of cell surface membrane receptors that are regarded as the primary receptors for one or more of the classical, naturally occurring prostanoids viz., prostaglandin D2, , PGE2, PGF2alpha, prostacyclin (PGI2), thromboxane A2 (TXA2), and PGH2.[1] They are named based on the prostanoid to which they preferentially bind and respond, e.g. the receptor responsive to PGI2 at lower concentrations than any other prostanoid is named the Prostacyclin receptor (IP). One exception to this rule is the receptor for thromboxane A2 (TP) which binds and responds to PGH2 and TXA2 equally well.

Cat. No.	Product name	CAS No.	Purity
TN2115	Pseudohypericin	55954-61-5	98%
TN2115	Pseudohypericin has photocytotoxic, and antiretroviral activities, it has potential therapeutic value in diseases such as AIDS.
TN4635	Neoechinulin A	51551-29-2	98%
TN4635	Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-ÎºB and p38 MAPK pathways, it may block the ...
T8603	ETHYL 2-AMINO-4-METHYL-5-PHENYLTHIOPHENE-3-CARBOXYLATE	4815-38-7	99.98%
T8603	ETHYL 2-AMINO-4-METHYL-5-PHENYLTHIOPHENE-3-CARBOXYLATE targets the prostaglandin E2 receptor EP2 subtype (human)
TN1006	Tirucallol	514-46-5	99.98%
TN1006	Tirucallol is an antiinflammatory agent isolated from Euphorbia lactea.Tirucallol exerts a topical anti-inflammatory effect in vivo, via a mechanism of action re...
T2396	Ramatroban	116649-85-5	99.96%
T2396	Ramatroban (BAY u3405) (BAY u3405) is a thromboxane A(2) (TxA(2)) antagonist marketed for allergic rhinitis. It has been used in trials studying the treatment of...
T7968	Dazoxiben	74226-22-5	99.94%
T7968	Dazoxiben (UK-37248) is a potent inhibitor of thromboxane (TX) synthase
T3216	Selexipag	475086-01-2	99.92%
T3216	Selexipag (ACT-293987)(NS-304) is prostacyclin receptor agonist that causes vasodilation in pulmonary vasculature and is used in the therapy of pulmonary arteria...
T5014	Prostaglandin E2	363-24-6	99.92%
T5014	Prostaglandin E2 (PGE2) is a naturally occurring hormone involved in a variety of physiological processes in the body, including smooth muscle contraction and re...
T15681	L-161982	147776-06-5	99.91%
T15681	L-161982 is a selective antagonist of EP4 receptor. L-161982 could inhibit PGE2-induced ERK phosphorylation and cell proliferation of HCA-7 cells. L-161982 could...
T1562	Rebamipide	90098-04-7	99.9%
T1562	Rebamipide (OPC12759) is a quinolinone derivative with anti-ulcer and anti-inflammatory activities. Rebamipide induces cyclooxygenase 2 (COX2) synthesis which re...
T2664	Timapiprant	851723-84-7	99.89%
T2664	Timapiprant (OC000459) is a potent and selective D prostanoid receptor 2 (DP2) antagonist (IC50: 13 nM).
T2868	Evodiamine	518-17-2	99.88%
T2868	Evodiamine (d-Evodiamine) is an alkaloid isolated from the fruit of daylily and has a variety of biological activities including anti-inflammatory, anti-obesity ...
T2538	Bimatoprost	155206-00-1	99.81%
T2538	Bimatoprost (AGN 192024) is a cloprostenol-derived amide that is used as an antihypertensive agent in the treatment of open-angle glaucoma and ocular hypertensio...
T3915	Ginsenoside Ro	34367-04-9	99.8%
T3915	Ginsenoside Ro (Chikusetsusaponin V) can reduce TXA2 production, weakly reduce COX-1 and TXAS activities, and has antiplatelet effects as a Ca2+ antagonist with ...
T3770	Taraxasterol	1059-14-9	99.79%
T3770	Taraxasterol (Taraxasterin) is compound with anti-inflammatory activity.
T2528	Latanoprost	130209-82-4	99.78%
T2528	Latanoprost (Xalatan) is a prostaglandin F2alpha analogue and a prostanoid selective FP receptor agonist with an ocular hypertensive effect.
T6625	Ozagrel hydrochloride	78712-43-3	99.78%
T6625	Ozagrel hydrochloride (OKY-046 HCl) is a selective thromboxane A(2) synthetase inhibitor used for the improvement of postoperative cerebrovascular contraction an...
T10960	Darbufelone	139226-28-1	99.77%
T10960	Darbufelone (CI-1004) is a non-competitive dual inhibitor of PGF2α and LTB4. Dabfilon effectively inhibits PGHS-2 with a Ki of 10 μM and IC50s of 0.19 μM and 20 ...
T4546	Dinoprost tromethamine salt	38562-01-5	99.73%
T4546	Dinoprost tromethamine salt (PGF2α THAM) is a naturally occurring prostaglandin used in medicine to induce labor and as an abortifacient.
T5150	Treprostinil	81846-19-7	99.71%
T5150	Treprostinil (Orenitram) is a potent DP1, IP and EP2 agonist (EC50: 0.6/1.9/6.2 nM).