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Potassium Channel

Potassium Channels. K+ channels are membrane proteins that allow rapid and selective flow of K+ ions across the cell membrane, and thus generate electrical signals in cells. Voltage-gated K+ channels (Kv channels), present in all animal cells, open and close upon changes in the transmembrane potential.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T6476 Dofetilide 115256-11-6 99.06%
Dofetilide
Dofetilide (UK 68789) is a sulfonamide class III antiarrhythmic agent and potassium channel blocker. Dofetilide selectively blocks cardiac ion channels of the ra...
T17227 Vernakalant Hydrochloride 748810-28-8 99.04%
Vernakalant Hydrochloride
Vernakalant Hydrochloride (RSD1235 hydrochloride) is a mixed voltage- and frequency-dependent Na+ and atria-preferred K+ channel blocker.
T6631 Quinine hydrochloride dihydrate 6119-47-7 99.04%
Quinine hydrochloride dihydrate
Quinine hydrochloride dihydrate (Quinine HCl Dihydrate) is a white crystalline K+ channel blocker, used to treat malaria.
T68038 Celivarone 401925-43-7 99.03%
Celivarone
Celivarone is a potassium channel blocker used in the study of arrhythmias, atrial flutter and atrial fibrillation.
T5585 AM-92016 hydrochloride 133229-11-5 99.02%
AM-92016 hydrochloride
AM-92016 is a specific blocker of rectifier potassium current. AM-92016 delays rectifier potassium channel and repolarizes the membrane thereby restricting the d...
T6186 TRAM-34 289905-88-0 99.01%
TRAM-34
TRAM-34 (Triarylmethane-34) (Kd=20 nM), an effective and specific inhibitor of the intermediate-conductance Ca2+-activated K+ channel (IKCa1, KCa3.1), does not b...
T0974 Novobiocin Sodium 1476-53-5 99%
Novobiocin Sodium
Novobiocin Sodium (Albamycinsodium) binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound derive...
T16444 PD-118057 313674-97-4 98.97%
PD-118057
PD-118057 is a potent ether associated (hERG) potassium channel activator that shows no activity against hERG. PD-118057 inhibits the excitability of the membran...
T17262 XE 991 dihydrochloride 122955-13-9 98.96%
XE 991 dihydrochloride
XE 991 dihydrochloride is a Kv7 (KCNQ) channel blocker. XE 991 dihydrochloride potently inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channel, and...
T16109 ML402 298684-44-3 98.93%
ML402
ML402 (ZINC3671497) is an activator of TREK-1 and TREK-2 with EC50s of 13.7 μM and 5.9 μM.
T1334 Hydroquinidine 1435-55-8 98.9%
Hydroquinidine
Hydroquinidine ((+)-Hydroquinidine) is an organic compound, used as an antiarrhythmic agent.
T26689 AVE-0118 498577-53-0 98.89%
AVE-0118
AVE-0118 is a potassium channel blocker and suppresses persistent atrial fibrillation.
T2996 Tetrandrine 518-34-3 98.88%
Tetrandrine
Tetrandrine (Sinomenine A) is a natural, bis-benzylisoquinoline alkaloid isolated from the root of the plant. Tetrandrine non-selectively inhibits calcium channe...
T28544 RL648_81 1919050-87-5 98.85%
RL648_81
RL648_81 is a selective activator of KCNQ2/3 channels (EC50 = 190 nM). RL648_81 can be used in studies about neuronal hyperexcitability neurologic disorders.
T1510 Rosuvastatin calcium 147098-20-2 98.85%
Rosuvastatin calcium
Rosuvastatin calcium (ZD4522) , a selective and competitive inhibitor of hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, has antilipidemic activit...
T8977 Kv2-IN-A1 689297-68-5 98.83%
Kv2-IN-A1
Kv2-IN-A1 is an inhibitor of Kv2.1 and Kv2.2.
T15555 IK1 inhibitor PA-6 500715-03-7 98.77%
IK1 inhibitor PA-6
IK1 inhibitor PA-6 (PA-6) is a selective and potent inhibitor of IK1 (KIR2.x ion-channel-carried inward rectifier current)(IC50 of 12-15 nM for human and mouse K...
TMS2171 (±)-Naringenin 67604-48-2 98.73%
(±)-Naringenin
(±)-Naringenin (Naringenine) is a natural product. It displays vasorelaxant effect on endothelium-denuded vessels via the activation of BKCa channels in myocytes...
T1049 Oxybutynin chloride 1508-65-2 98.71%
Oxybutynin chloride
Oxybutynin chloride (Oxybutynin HCl) is an anticholinergic medication used to relieve urinary and bladder difficulties. It competitively antagonizes the M1, M2, ...
T1603 Glipizide 29094-61-9 98.66%
Glipizide
Glipizide (CP 28720) is a short-acting, second-generation sulfonylurea with hypoglycemic activity.
Dofetilide
T6476
Dofetilide (UK 68789) is a sulfonamide class III antiarrhythmic agent and potassium channel blocker. Dofetilide selectively blocks cardiac ion channels of the ra...
Vernakalant Hydrochloride
T17227
Vernakalant Hydrochloride (RSD1235 hydrochloride) is a mixed voltage- and frequency-dependent Na+ and atria-preferred K+ channel blocker.
Quinine hydrochloride dihydrate
T6631
Quinine hydrochloride dihydrate (Quinine HCl Dihydrate) is a white crystalline K+ channel blocker, used to treat malaria.
Celivarone
T68038
Celivarone is a potassium channel blocker used in the study of arrhythmias, atrial flutter and atrial fibrillation.
AM-92016 hydrochloride
T5585
AM-92016 is a specific blocker of rectifier potassium current. AM-92016 delays rectifier potassium channel and repolarizes the membrane thereby restricting the d...
TRAM-34
T6186
TRAM-34 (Triarylmethane-34) (Kd=20 nM), an effective and specific inhibitor of the intermediate-conductance Ca2+-activated K+ channel (IKCa1, KCa3.1), does not b...
Novobiocin Sodium
T0974
Novobiocin Sodium (Albamycinsodium) binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound derive...
PD-118057
T16444
PD-118057 is a potent ether associated (hERG) potassium channel activator that shows no activity against hERG. PD-118057 inhibits the excitability of the membran...
XE 991 dihydrochloride
T17262
XE 991 dihydrochloride is a Kv7 (KCNQ) channel blocker. XE 991 dihydrochloride potently inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channel, and...
ML402
T16109
ML402 (ZINC3671497) is an activator of TREK-1 and TREK-2 with EC50s of 13.7 μM and 5.9 μM.
Hydroquinidine
T1334
Hydroquinidine ((+)-Hydroquinidine) is an organic compound, used as an antiarrhythmic agent.
AVE-0118
T26689
AVE-0118 is a potassium channel blocker and suppresses persistent atrial fibrillation.
Tetrandrine
T2996
Tetrandrine (Sinomenine A) is a natural, bis-benzylisoquinoline alkaloid isolated from the root of the plant. Tetrandrine non-selectively inhibits calcium channe...
RL648_81
T28544
RL648_81 is a selective activator of KCNQ2/3 channels (EC50 = 190 nM). RL648_81 can be used in studies about neuronal hyperexcitability neurologic disorders.
Rosuvastatin calcium
T1510
Rosuvastatin calcium (ZD4522) , a selective and competitive inhibitor of hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, has antilipidemic activit...
Kv2-IN-A1
T8977
Kv2-IN-A1 is an inhibitor of Kv2.1 and Kv2.2.
IK1 inhibitor PA-6
T15555
IK1 inhibitor PA-6 (PA-6) is a selective and potent inhibitor of IK1 (KIR2.x ion-channel-carried inward rectifier current)(IC50 of 12-15 nM for human and mouse K...
(±)-Naringenin
TMS2171
(±)-Naringenin (Naringenine) is a natural product. It displays vasorelaxant effect on endothelium-denuded vessels via the activation of BKCa channels in myocytes...
Oxybutynin chloride
T1049
Oxybutynin chloride (Oxybutynin HCl) is an anticholinergic medication used to relieve urinary and bladder difficulties. It competitively antagonizes the M1, M2, ...
Glipizide
T1603
Glipizide (CP 28720) is a short-acting, second-generation sulfonylurea with hypoglycemic activity.
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TargetMol