T30544 |
BMS-919373
|
1272353-82-8
|
98.51%
|
|
BMS-919373 is a potassium channel Kv1.5 (KCNA5) inhibitor for atrial fibrillation and acute coronary syndrome.
|
TN1757 |
Hypophyllanthin
|
33676-00-5
|
98.39%
|
|
Hypophyllanthin and phyllanthin have antitumour effects against Ehrlich Ascites Carcinoma in mice.
|
T1054 |
Tolbutamide
|
64-77-7
|
98.37%
|
|
Tolbutamide (HLS 831) is a sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE.
|
T3192 |
NS1643
|
448895-37-2
|
98.37%
|
|
NS1643 is a potent human ether-a-go-go related gene (hERG) KV11.1 channel activator with EC50 of 10.5 μM.
|
T7653 |
JNJ 303
|
878489-28-2
|
98.33%
|
|
JNJ 303 is a potent blocker of IKs (IC50 : 64 nM).
|
T5336 |
Zacopride hydrochloride
|
101303-98-4
|
98.32%
|
|
Zacopride is a highly potent 5-HT3 receptor antagonist (Kd = 0.38 nM) and 5-HT4 receptor agonist (Ki = 373 nM). It also is a selective IK1 channel agonist.
|
T0161 |
Pantoprazole Sodium Hydrate
|
164579-32-2
|
98.32%
|
|
Pantoprazole Sodium Hydrate (BY1023 (sodium hydrate)) is a proton pump inhibitor drug, used for short-term treatment of erosion and ulceration of the esophagus c...
|
T9070 |
ASP2905
|
792184-90-8
|
98.29%
|
|
ASP-2905 is a potent and selective inhibitor of potassium channel Kv12.2 encoded by the Kcnh3/BEC1 gene. It can cross the blood-brain barrier and has antipsychot...
|
T3102 |
NS-1619
|
153587-01-0
|
98.28%
|
|
NS1619 have cardio-protective effects after ischemia-reperfusion injury.
|
T30520 |
BMS-394136
|
343246-73-1
|
98.25%
|
|
BMS-394136 (BMS 394136) is a KV1.5 antagonist for the treatment of cardiovascular diseases such as arrhythmias and atrial fibrillation.
|
T14666 |
BL-1249
|
18200-13-0
|
98.25%
|
|
BL-1249 is a selective and potent non-steroidal potassium channel activator with anti-inflammatory activity that activates K2P2.1 (TREK-1) and K2P10.1 (TREK-2).
|
T1278 |
Astemizole
|
68844-77-9
|
98.24%
|
|
Astemizole (Laridal) is a synthetic piperidinyl-benzimidazol derivative with antiallergic properties, acts as a reversible competitive inhibitor of histamine H1 ...
|
T14984 |
CLP257
|
1181081-71-9
|
98.13%
|
|
CLP257 is a selective K+-Cl− cotransporter KCC2 activator (EC50: 616 nM) and it is inactive against NKCC1, GABAA receptors, KCC1, KCC3 or KCC4. CLP257 alleviate...
|
T12504 |
(+)-KCC2 blocker 1
|
1228439-71-1
|
98.12%
|
|
(+)-KCC2 blocker 1 is a selective blocker of KCC2 (IC50 = 0.4 μM).
|
T16347 |
NS3623
|
343630-41-1
|
98.1%
|
|
NS3623 is an activator of human ether-a-go-go-related gene potassium channels. NS3623 has a dual mode of action, being an inhibitor of hERG1 channels. NS3623 act...
|
T16110 |
ML418
|
1928763-08-9
|
98.1%
|
|
ML418 is a potent, selective and CNS penetrating Kir7.1 potassium channel blocker (IC50 = 310 nM), and also potently inhibits Kir6.2/SUR1.
|
T1527 |
Gliclazide
|
21187-98-4
|
98.08%
|
|
Gliclazide (SE1702), an oral antihyperglycemic agent, belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating beta-cells of the panc...
|
T23516 |
VU590
|
313505-85-0
|
98.06%
|
|
VU590 is a potent and moderately selective inhibitor of extrarenal medullary potassium ROMK (Kir1.1).VU590 inhibits Kir7.1 and modulates uterine myometrial contr...
|
T8372 |
VU0134992
|
755002-90-5
|
98.03%
|
|
VU0134992 is an Kir4.1 blocker with an IC50 value of 0.97 μM
|
T68730 |
AVE1231
|
767334-89-4
|
98.03%
|
|
AVE1231 is a TASK-1 channel blocker that inhibits TASK-1 and can be used in the study of atrial fibrillation.
|