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Potassium Channel

Potassium Channels. K+ channels are membrane proteins that allow rapid and selective flow of K+ ions across the cell membrane, and thus generate electrical signals in cells. Voltage-gated K+ channels (Kv channels), present in all animal cells, open and close upon changes in the transmembrane potential.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T5585 AM-92016 hydrochloride 133229-11-5 99.02%
AM-92016 hydrochloride
AM-92016 is a specific blocker of rectifier potassium current. AM-92016 delays rectifier potassium channel and repolarizes the membrane thereby restricting the d...
T6186 TRAM-34 289905-88-0 99.01%
TRAM-34
TRAM-34 (Triarylmethane-34) (Kd=20 nM), an effective and specific inhibitor of the intermediate-conductance Ca2+-activated K+ channel (IKCa1, KCa3.1), does not b...
T6504 Flupirtine maleate 75507-68-5 98.99%
Flupirtine maleate
Flupirtine maleate (Katadolon maleate), a centrally acting non-opioid analgesia, is the salt form of Flupirtine. It is an NMDA receptor antagonist , and also a s...
T3402 20(S)-Ginsenoside Rg3 14197-60-5 98.99%
20(S)-Ginsenoside Rg3
20(S)-Ginsenoside Rg3 (Rg3) possess an ability to inhibit the lung metastasis of tumor cells via inhibition of the adhesion and invasion of tumor cells. It inhib...
T16444 PD-118057 313674-97-4 98.97%
PD-118057
PD-118057 is a potent ether associated (hERG) potassium channel activator that shows no activity against hERG. PD-118057 inhibits the excitability of the membran...
T17262 XE 991 dihydrochloride 122955-13-9 98.96%
XE 991 dihydrochloride
XE 991 dihydrochloride is a Kv7 (KCNQ) channel blocker. XE 991 dihydrochloride potently inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channel, and...
T16109 ML402 298684-44-3 98.93%
ML402
ML402 (ZINC3671497) is an activator of TREK-1 and TREK-2 with EC50s of 13.7 μM and 5.9 μM.
T1334 Hydroquinidine 1435-55-8 98.9%
Hydroquinidine
Hydroquinidine ((+)-Hydroquinidine) is an organic compound, used as an antiarrhythmic agent.
T26689 AVE-0118 498577-53-0 98.89%
AVE-0118
AVE-0118 is a potassium channel blocker and suppresses persistent atrial fibrillation.
T2996 Tetrandrine 518-34-3 98.88%
Tetrandrine
Tetrandrine (Sinomenine A) is a natural, bis-benzylisoquinoline alkaloid isolated from the root of the plant. Tetrandrine non-selectively inhibits calcium channe...
T28544 RL648_81 1919050-87-5 98.85%
RL648_81
RL648_81 is a selective activator of KCNQ2/3 channels (EC50 = 190 nM). RL648_81 can be used in studies about neuronal hyperexcitability neurologic disorders.
T1510 Rosuvastatin calcium 147098-20-2 98.85%
Rosuvastatin calcium
Rosuvastatin calcium (ZD4522) , a selective and competitive inhibitor of hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, has antilipidemic activit...
T8977 Kv2-IN-A1 689297-68-5 98.83%
Kv2-IN-A1
Kv2-IN-A1 is an inhibitor of Kv2.1 and Kv2.2.
T15555 IK1 inhibitor PA-6 500715-03-7 98.77%
IK1 inhibitor PA-6
IK1 inhibitor PA-6 (PA-6) is a selective and potent inhibitor of IK1 (KIR2.x ion-channel-carried inward rectifier current)(IC50 of 12-15 nM for human and mouse K...
TMS2171 (±)-Naringenin 67604-48-2 98.73%
(±)-Naringenin
(±)-Naringenin (Naringenine) is a natural product. It displays vasorelaxant effect on endothelium-denuded vessels via the activation of BKCa channels in myocytes...
T1603 Glipizide 29094-61-9 98.66%
Glipizide
Glipizide (CP 28720) is a short-acting, second-generation sulfonylurea with hypoglycemic activity.
T1206 Amsacrine 51264-14-3 98.59%
Amsacrine
Amsacrine (AMSA) (mAMSA) an antineoplastic agent which can intercalate into the DNA of tumor cells. Amsacrine also expresses topoisomerase inhibitor activity, sp...
T32873 Maralixibat Chloride 228113-66-4 98.54%
Maralixibat Chloride
Maralixibat Chloride (LUM001 chloride), an apical, sodium-dependent, bile acid transport inhibitor, prevents enterohepatic bile acid recirculation.
T0075 Nicorandil 65141-46-0 98.52%
Nicorandil
Nicorandil (SG-75)(Ikorel) acts by relaxing the smooth muscle of the blood vessels, especially those of the venous system. It undertakes this through two methods...
T15385 Glibornuride 26944-48-9 98.51%
Glibornuride
Glibornuride is an ATP-sensitive K+ channels (KATP channel) blocker ( pKi: 5.75). It is an antidiabetic agent.
AM-92016 hydrochloride
T5585
AM-92016 is a specific blocker of rectifier potassium current. AM-92016 delays rectifier potassium channel and repolarizes the membrane thereby restricting the d...
TRAM-34
T6186
TRAM-34 (Triarylmethane-34) (Kd=20 nM), an effective and specific inhibitor of the intermediate-conductance Ca2+-activated K+ channel (IKCa1, KCa3.1), does not b...
Flupirtine maleate
T6504
Flupirtine maleate (Katadolon maleate), a centrally acting non-opioid analgesia, is the salt form of Flupirtine. It is an NMDA receptor antagonist , and also a s...
20(S)-Ginsenoside Rg3
T3402
20(S)-Ginsenoside Rg3 (Rg3) possess an ability to inhibit the lung metastasis of tumor cells via inhibition of the adhesion and invasion of tumor cells. It inhib...
PD-118057
T16444
PD-118057 is a potent ether associated (hERG) potassium channel activator that shows no activity against hERG. PD-118057 inhibits the excitability of the membran...
XE 991 dihydrochloride
T17262
XE 991 dihydrochloride is a Kv7 (KCNQ) channel blocker. XE 991 dihydrochloride potently inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channel, and...
ML402
T16109
ML402 (ZINC3671497) is an activator of TREK-1 and TREK-2 with EC50s of 13.7 μM and 5.9 μM.
Hydroquinidine
T1334
Hydroquinidine ((+)-Hydroquinidine) is an organic compound, used as an antiarrhythmic agent.
AVE-0118
T26689
AVE-0118 is a potassium channel blocker and suppresses persistent atrial fibrillation.
Tetrandrine
T2996
Tetrandrine (Sinomenine A) is a natural, bis-benzylisoquinoline alkaloid isolated from the root of the plant. Tetrandrine non-selectively inhibits calcium channe...
RL648_81
T28544
RL648_81 is a selective activator of KCNQ2/3 channels (EC50 = 190 nM). RL648_81 can be used in studies about neuronal hyperexcitability neurologic disorders.
Rosuvastatin calcium
T1510
Rosuvastatin calcium (ZD4522) , a selective and competitive inhibitor of hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, has antilipidemic activit...
Kv2-IN-A1
T8977
Kv2-IN-A1 is an inhibitor of Kv2.1 and Kv2.2.
IK1 inhibitor PA-6
T15555
IK1 inhibitor PA-6 (PA-6) is a selective and potent inhibitor of IK1 (KIR2.x ion-channel-carried inward rectifier current)(IC50 of 12-15 nM for human and mouse K...
(±)-Naringenin
TMS2171
(±)-Naringenin (Naringenine) is a natural product. It displays vasorelaxant effect on endothelium-denuded vessels via the activation of BKCa channels in myocytes...
Glipizide
T1603
Glipizide (CP 28720) is a short-acting, second-generation sulfonylurea with hypoglycemic activity.
Amsacrine
T1206
Amsacrine (AMSA) (mAMSA) an antineoplastic agent which can intercalate into the DNA of tumor cells. Amsacrine also expresses topoisomerase inhibitor activity, sp...
Maralixibat Chloride
T32873
Maralixibat Chloride (LUM001 chloride), an apical, sodium-dependent, bile acid transport inhibitor, prevents enterohepatic bile acid recirculation.
Nicorandil
T0075
Nicorandil (SG-75)(Ikorel) acts by relaxing the smooth muscle of the blood vessels, especially those of the venous system. It undertakes this through two methods...
Glibornuride
T15385
Glibornuride is an ATP-sensitive K+ channels (KATP channel) blocker ( pKi: 5.75). It is an antidiabetic agent.
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TargetMol