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Phospholipase

A phospholipase is an enzyme that hydrolyzes phospholipids[1] into fatty acids and other lipophilic substances. There are four major classes, termed A, B, C and D, which are distinguished by the type of reaction which they catalyze.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
TQ0159 U-73343 142878-12-4 99.06%
U-73343
U-73343 is an inactive analog of U-73122 and can be used as a negative control. It dose-dependently inhibits acid secretion irrespective of the stimulant. It is ...
T11149 Ecopladib 381683-92-7 99.02%
Ecopladib
Ecopladib (PLA 725) is a sub-micromolar inhibitor of cytosolic phospholipase A2α (cPLA2α), with IC50s of 0.15 μM and 0.11 μM in the GLU micelle and rat whole blo...
T21606L Anti-Inflammatory Peptide 1 Acetate T21606L 98.95%
Anti-Inflammatory Peptide 1 Acetate
Anti-Inflammatory Peptide 1 Acetate (C45H82N12O14S2) possesses a potent anti-inflammatory activity in vivo and is a strong inhibitor of phospholipase A2 (PLA2), ...
T4192 Hnps-PLA Inhibitor 185298-58-2 98.95%
hnps-PLA Inhibitor
Hnps-PLA Inhibitor is an inhibitor of human nonpancreatic secretory Phospholipase A (hnps-PLA).
T4511 ST271 106392-48-7 98.94%
ST271
ST271 is an effective protein tyrosine kinase (PTK) inhibitor.
T60967 Atg4B-IN-2 2765008-88-4 98.86%
Atg4B-IN-2
Atg4B-IN-2 is a potent and selective Atg4B inhibitor with anticancer activity that inhibits the activity of Atg4B and PLA2.Atg4B-IN-2 resists the anticancer acti...
T60043 DPTIP 351353-48-5 98.80%
DPTIP
DPTIP is an effective inhibitor of neutral sphingomyelinase 2 with an IC50 value of 30 nM.
T2907 Tanshinone I 568-73-0 98.58%
Tanshinone I
Tanshinone I (Tanshinone A), an active principle isolated from the herbal medicine Salvia miltiorrhiza, displays cytotoxicity against tumor cells.
T4019 Cambinol 14513-15-6 98.47%
Cambinol
Cambinol (SIRT1/2 Inhibitor IV) is a cell-permeable b-naphthol compound that inhibits the NAD-dependent deacetylase activity of SIRT1/2 (IC50: 56/59 μM, respecti...
TP1299 Melittin 20449-79-0 98.37%
Melittin
Melittin, a small protein containing 26 amino acid residues, is the principal toxic component of bee venom. Melittin is a PLA2 activator, stimulates the activity...
T21651 Lansoprazole sodium 226904-00-3 98.35%
Lansoprazole sodium
Lansoprazole sodium (Lansoprazole (sodium)) is a proton pump inhibitor (PPI) and a potent inhibitor of gastric acidity which is widely used in the therapy of gas...
T17239 VU0155069 1130067-06-9 98.32%
VU0155069
VU0155069 strongly inhibits the invasive migration of several cancer cell lines in transwell assays. VU0155069 is a selective phospholipase D1 inhibitor (IC50: 4...
T13632 D-Erythro-dihydrosphingosine 764-22-7 98.03%
D-Erythro-dihydrosphingosine
D-Erythro-dihydrosphingosine (C18-Dihydrosphingosine) inhibits arachidonic acid release and cPLA2α activity.
T8236 RHC 80267 83654-05-1 98%
RHC 80267
RHC 80267 (U-57908) is a selective inhibitor of DAGL (IC50 : 4 μM in canine platelets)
T2044 Varespladib 172732-68-2 98%
Varespladib
Varespladib (LY315920), a specific and effective human non-pancreatic secretory phospholipase A2 (hnsPLA) inhibitor(IC50=7 nM), has been investigated for the tre...
T7280 CAY10594 1130067-34-3 98%
CAY10594
CAY10594 is a potent phospholipase D2(PLD2) inhibitor. CAY10594 ameliorates acetaminophen-induced acute liver injury by regulating the phosphorylated-GSK-3β/JNK ...
T2282 RPI-1 269730-03-2 98%
RPI-1
RPI-1 is a competitive, potent ATP-dependent Ret kinase inhibitor.
T6243 U-73122 112648-68-7 97.98%
U-73122
U-73122 (U73122) , an effective PLC inhibitor, reduces agonist-induced Ca2+ increases in platelets and PMN.
T70955 Vinaxanthone 133293-89-7 97.65%
Vinaxanthone
Vinaxanthone (SM-345431) is a small molecule compound derived from Penicillium chrysogenum that is a selective and potent semaphorin3A, phospholipase C (PLC), an...
T0757 Omeprazole 73590-58-6 97.61%
Omeprazole
Omeprazole (Losec) is a proton pump inhibitor (PPI), Omeprazole(Losec) is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibito...
U-73343
TQ0159
U-73343 is an inactive analog of U-73122 and can be used as a negative control. It dose-dependently inhibits acid secretion irrespective of the stimulant. It is ...
Ecopladib
T11149
Ecopladib (PLA 725) is a sub-micromolar inhibitor of cytosolic phospholipase A2α (cPLA2α), with IC50s of 0.15 μM and 0.11 μM in the GLU micelle and rat whole blo...
Anti-Inflammatory Peptide 1 Acetate
T21606L
Anti-Inflammatory Peptide 1 Acetate (C45H82N12O14S2) possesses a potent anti-inflammatory activity in vivo and is a strong inhibitor of phospholipase A2 (PLA2), ...
hnps-PLA Inhibitor
T4192
Hnps-PLA Inhibitor is an inhibitor of human nonpancreatic secretory Phospholipase A (hnps-PLA).
ST271
T4511
ST271 is an effective protein tyrosine kinase (PTK) inhibitor.
Atg4B-IN-2
T60967
Atg4B-IN-2 is a potent and selective Atg4B inhibitor with anticancer activity that inhibits the activity of Atg4B and PLA2.Atg4B-IN-2 resists the anticancer acti...
DPTIP
T60043
DPTIP is an effective inhibitor of neutral sphingomyelinase 2 with an IC50 value of 30 nM.
Tanshinone I
T2907
Tanshinone I (Tanshinone A), an active principle isolated from the herbal medicine Salvia miltiorrhiza, displays cytotoxicity against tumor cells.
Cambinol
T4019
Cambinol (SIRT1/2 Inhibitor IV) is a cell-permeable b-naphthol compound that inhibits the NAD-dependent deacetylase activity of SIRT1/2 (IC50: 56/59 μM, respecti...
Melittin
TP1299
Melittin, a small protein containing 26 amino acid residues, is the principal toxic component of bee venom. Melittin is a PLA2 activator, stimulates the activity...
Lansoprazole sodium
T21651
Lansoprazole sodium (Lansoprazole (sodium)) is a proton pump inhibitor (PPI) and a potent inhibitor of gastric acidity which is widely used in the therapy of gas...
VU0155069
T17239
VU0155069 strongly inhibits the invasive migration of several cancer cell lines in transwell assays. VU0155069 is a selective phospholipase D1 inhibitor (IC50: 4...
D-Erythro-dihydrosphingosine
T13632
D-Erythro-dihydrosphingosine (C18-Dihydrosphingosine) inhibits arachidonic acid release and cPLA2α activity.
RHC 80267
T8236
RHC 80267 (U-57908) is a selective inhibitor of DAGL (IC50 : 4 μM in canine platelets)
Varespladib
T2044
Varespladib (LY315920), a specific and effective human non-pancreatic secretory phospholipase A2 (hnsPLA) inhibitor(IC50=7 nM), has been investigated for the tre...
CAY10594
T7280
CAY10594 is a potent phospholipase D2(PLD2) inhibitor. CAY10594 ameliorates acetaminophen-induced acute liver injury by regulating the phosphorylated-GSK-3β/JNK ...
RPI-1
T2282
RPI-1 is a competitive, potent ATP-dependent Ret kinase inhibitor.
U-73122
T6243
U-73122 (U73122) , an effective PLC inhibitor, reduces agonist-induced Ca2+ increases in platelets and PMN.
Vinaxanthone
T70955
Vinaxanthone (SM-345431) is a small molecule compound derived from Penicillium chrysogenum that is a selective and potent semaphorin3A, phospholipase C (PLC), an...
Omeprazole
T0757
Omeprazole (Losec) is a proton pump inhibitor (PPI), Omeprazole(Losec) is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibito...
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TargetMol