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Phospholipase

A phospholipase is an enzyme that hydrolyzes phospholipids[1] into fatty acids and other lipophilic substances. There are four major classes, termed A, B, C and D, which are distinguished by the type of reaction which they catalyze.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T8968 ML299 1426916-00-8 98%
ML299
ML299 (VU0463568) is a dual PLD1/2 inhibitor (PLD1 and PLD2, IC50 of 6 nM, 20 nM, respectively).
TP1299 Melittin 20449-79-0 98%
Melittin
Melittin, a small protein containing 26 amino acid residues, is the principal toxic component of bee venom. Melittin is a PLA2 activator, stimulates the activity...
T21681 AACOCF3 149301-79-1 98%
AACOCF3
AACOCF3 (Arachidonyl trifluoromethyl ketone) is a cell-permeable trifluoromethyl ketone analog of arachidonic acid. It is a potent and selective slow binding inh...
TN7075 Linocinnamarin 554-87-0 99.95%
Linocinnamarin
Linocinnamarin (3-[4-(beta-D-Glucopyranosyloxy)phenyl]acrylic acid methyl ester) is isolated from Fragaria ananassa Duch. (strawberry). The inhibition of antigen...
T3616 Carbazochrome 69-81-8 99.95%
Carbazochrome
Carbazochrome (Adchnon) is an antihemorrhagic, or hemostatic, agent that will cease blood flow by causing the aggregation and adhesion of platelets in the blood ...
T8531 M-3M3FBS 200933-14-8 99.92%
m-3M3FBS
m-3M3FBS is a phospholipase C (PLC) activator.
T6109 Darapladib 356057-34-6 99.85%
Darapladib
Darapladib (SB-480848)(IC50=0.25 nM) is a substituted pyrimidone with inhibitory activity towards lipoprotein-associated phospholipase-A2 (Lp-PLA2).
T6529 Halobetasol propionate 66852-54-8 99.85%
Halobetasol  propionate
Halobetasol propionate (BMY-30056) is the propionate salt form of halobetasol, a synthetic corticosteroid with anti-inflammatory, antipruritic, and vasoconstrict...
T0674 Lansoprazole 103577-45-3 99.84%
Lansoprazole
Lansoprazole (A-65006) is a 2, 2, 2-trifluoroethoxypyridyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME...
T0693 Niflumic acid 4394-00-7 99.79%
Niflumic acid
Niflumic acid (Nifluril) is a Ca2+-activated Cl- channel blocker and an analgesic and anti-inflammatory agent used in the therapy of rheumatoid arthritis.
TP1299L1 Melittin Acetate 99.78%
Melittin Acetate
Melittin Acetate (Forapin Acetate) is a PLA2 activator. Melittin Acetate stimulates the activity of the low molecular weight PLA2, while it does not increase the...
T4S0590 Columbin 546-97-4 99.74%
Columbin
1. Columbin has anti-inflammatory activity. 2. Columbin has chemopreventive ability against human colon cancer. 3. Columbin inhibits PLA2 hydrolysis of ghost RBC...
TN4893 Rapanone 573-40-0 99.72%
Rapanone
Rapanone (2,5-Dihydroxy-3-tridecyl-[1,4]benzoquinone) is a natural benzoquinone that is a potent and selective inhibitor of human synovial PLA2.
T8966 ML-298 1426916-02-0 99.7%
ML-298
ML-298 (CID53393915) is a potent, specific inhibitor of Phospholipase D2 (PLD2, IC50 of 355 nM).
T17218 Varespladib methyl 172733-08-3 99.69%
Varespladib methyl
Varespladib methyl (LY333013), a bioavailable prodrug of Varespladib, is a selective group II secretory phospholipase A2 inhibitor.
T31929 Giripladib 865200-20-0 99.68%
Giripladib
Giripladib (PLA695)(PLX-695) is a cPLA2-specific inhibitor that inhibits the radiation-induced increase of phosphorylated ERK and phosphorylated Akt in endotheli...
T10168 5-HT1A modulator 1 142477-34-7 99.66%
5-HT1A modulator 1
5-HT1A modulator 1 displays very high affinities for the 5-HT1A, α1-adrenergic receptor, and D2 receptor (IC50s = 2 nM, 10 nM, and 40 nM).
T3640 GW4869 6823-69-4 99.66%
GW4869
GW4869 (GW69A) is a noncompetitive inhibitor of neutral sphingomyelinase (N-SMase, IC50 of 1 μM). GW4869(GW 4869) is an exosome biogenesis/release inhibitor.
T0188 Fluticasone (propionate) 80474-14-2 99.65%
Fluticasone (propionate)
Fluticasone propionate (CCI-187881), derived from fluticasone used to remedy asthma and allergic rhinitis, is a high affinity, selective GR (glucocorticoid recep...
T67749 Fuzapladib 141283-87-6 99.65%
Fuzapladib
Fuzapladib (IS-741) (IS-741) is a phospholipase A2 inhibitor that can inhibits the expression of Mac-1, a cell adhesion molecule. Fuzapladib blocks activation of...
ML299
T8968
ML299 (VU0463568) is a dual PLD1/2 inhibitor (PLD1 and PLD2, IC50 of 6 nM, 20 nM, respectively).
Melittin
TP1299
Melittin, a small protein containing 26 amino acid residues, is the principal toxic component of bee venom. Melittin is a PLA2 activator, stimulates the activity...
AACOCF3
T21681
AACOCF3 (Arachidonyl trifluoromethyl ketone) is a cell-permeable trifluoromethyl ketone analog of arachidonic acid. It is a potent and selective slow binding inh...
Linocinnamarin
TN7075
Linocinnamarin (3-[4-(beta-D-Glucopyranosyloxy)phenyl]acrylic acid methyl ester) is isolated from Fragaria ananassa Duch. (strawberry). The inhibition of antigen...
Carbazochrome
T3616
Carbazochrome (Adchnon) is an antihemorrhagic, or hemostatic, agent that will cease blood flow by causing the aggregation and adhesion of platelets in the blood ...
m-3M3FBS
T8531
m-3M3FBS is a phospholipase C (PLC) activator.
Darapladib
T6109
Darapladib (SB-480848)(IC50=0.25 nM) is a substituted pyrimidone with inhibitory activity towards lipoprotein-associated phospholipase-A2 (Lp-PLA2).
Halobetasol propionate
T6529
Halobetasol propionate (BMY-30056) is the propionate salt form of halobetasol, a synthetic corticosteroid with anti-inflammatory, antipruritic, and vasoconstrict...
Lansoprazole
T0674
Lansoprazole (A-65006) is a 2, 2, 2-trifluoroethoxypyridyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME...
Niflumic acid
T0693
Niflumic acid (Nifluril) is a Ca2+-activated Cl- channel blocker and an analgesic and anti-inflammatory agent used in the therapy of rheumatoid arthritis.
Melittin Acetate
TP1299L1
Melittin Acetate (Forapin Acetate) is a PLA2 activator. Melittin Acetate stimulates the activity of the low molecular weight PLA2, while it does not increase the...
Columbin
T4S0590
1. Columbin has anti-inflammatory activity. 2. Columbin has chemopreventive ability against human colon cancer. 3. Columbin inhibits PLA2 hydrolysis of ghost RBC...
Rapanone
TN4893
Rapanone (2,5-Dihydroxy-3-tridecyl-[1,4]benzoquinone) is a natural benzoquinone that is a potent and selective inhibitor of human synovial PLA2.
ML-298
T8966
ML-298 (CID53393915) is a potent, specific inhibitor of Phospholipase D2 (PLD2, IC50 of 355 nM).
Varespladib methyl
T17218
Varespladib methyl (LY333013), a bioavailable prodrug of Varespladib, is a selective group II secretory phospholipase A2 inhibitor.
Giripladib
T31929
Giripladib (PLA695)(PLX-695) is a cPLA2-specific inhibitor that inhibits the radiation-induced increase of phosphorylated ERK and phosphorylated Akt in endotheli...
5-HT1A modulator 1
T10168
5-HT1A modulator 1 displays very high affinities for the 5-HT1A, α1-adrenergic receptor, and D2 receptor (IC50s = 2 nM, 10 nM, and 40 nM).
GW4869
T3640
GW4869 (GW69A) is a noncompetitive inhibitor of neutral sphingomyelinase (N-SMase, IC50 of 1 μM). GW4869(GW 4869) is an exosome biogenesis/release inhibitor.
Fluticasone (propionate)
T0188
Fluticasone propionate (CCI-187881), derived from fluticasone used to remedy asthma and allergic rhinitis, is a high affinity, selective GR (glucocorticoid recep...
Fuzapladib
T67749
Fuzapladib (IS-741) (IS-741) is a phospholipase A2 inhibitor that can inhibits the expression of Mac-1, a cell adhesion molecule. Fuzapladib blocks activation of...
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TargetMol