PKC

Protein kinase C, commonly abbreviated to PKC, is a family of protein kinase enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins, or a member of this family. PKC enzymes in turn are activated by signals such as increases in the concentration of diacylglycerol (DAG) or calcium ions (Ca2+). Hence PKC enzymes play important roles in several signal transduction cascades.

Cat. No.	Product name	CAS No.	Purity
T0979	Dequalinium chloride	522-51-0	99.58%
T0979	Dequalinium Chloride, a topical bacteriostat, is a selective blocker of apamin-sensitive K+ channels. It is used in wound dressings and mouth infections and may ...
T6139L	A-674563 2HCl(552325-73-2(fb-2hcl))	T6139L	99.57%
T6139L	A-674563 2HCl is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC.
T3211	Midostaurin	120685-11-2	99.56%
T3211	PKC412(Midostaurin; CGP41231; CGP41251) is a broad spectrum protein kinase inhibitor. Midostaurin inhibits protein kinase C alpha (PKCalpha), vascular endothelia...
T7792	Hispidin	555-55-5	99.55%
T7792	Hispidin is a polyphenol originally, including antioxidant, anti-inflammatory, and cytoprotective properties
T0033	Miltefosine	58066-85-6	99.51%
T0033	Miltefosine is the treatment of visceral and cutaneous leishmaniasis drug , and is proceeding clinical trials for this in several countries. Several medical agen...
T6S0923	Hypericin	548-04-9	99.51%
T6S0923	1. Hypericin has antineoplastic activity. 2. Hypericin has antibiotic and antiviral activities. 3. Hypericin has antidepressive activity through inhibiting monoa...
T13314	VTX-27	1321924-70-2	99.49%
T13314	VTX-27 is a selective inhibitor of protein kinase C θ (PKC θ) (Kis: 0.08 nM and 16 nM for PKC θ and PKC δ).
T13384L	Y-33075 dihydrochloride	173897-44-4	99.43%
T13384L	Y-33075 dihydrochloride is a selective inhibitor of ROCK(IC50 of 3.6 nM).
T0610	Piceatannol	10083-24-6	99.39%
T0610	Piceatannol is an anti-inflammatory, immunomodulatory and antiproliferative agent. It inhibits p56lck and syk protein tyrosine kinases and inhibits NF-κB activat...
T5796	Plantainoside D	147331-98-4	99.39%
T5796	Plantainoside D shows potent antioxidative effects as those of ascorbic acid, it shows angiotensin-converting enzyme (ACE) inhibitory inhibitory activity in vitr...
T12148	N-Desmethyltamoxifen hydrochloride	15917-65-4	99.34%
T12148	N-Desmethyltamoxifen hydrochloride is the major tamoxifen metabolite in humans.
TN1136	Procyanidin A1	103883-03-0	99.23%
TN1136	Procyanidin A1 (Proanthocyanidin A1) has antiallergic effects, it inhibits degranulation downstream of protein kinase C activation or Ca2+; influx from an intern...
T6643	Ro 31-8220 Mesylate	138489-18-6	99.18%
T6643	Ro 31-8220 Mesylate (Bisindolylmaleimide IX mesylate) is a pan-PKC inhibitor for PKC-α/βI/βII/γ/ε (IC50: 5/24/14/27/24 nM), and also shows potent inhibition agai...
T6932	PD168393	194423-15-9	99.13%
T6932	PD168393 is an irreversible EGFR inhibitor (IC50: 0.70 nM), irreversibly alkylate Cys-773; inactive against PKC, FGFR, PDGFR, and insulin.
TN1047	Ingenol mebutate	75567-37-2	99.04%
TN1047	Ingenol mebutate is a potent activator of PKC subtypes including PKC-α, PKC-β, PKC-γ, PKC-δ, and PKC-ε with Kis of 0.3, 0.105, 0.162, 0.376, and 0.171 nM. Ingeno...
T27525	HA-1004	91742-10-8	99.03%
T27525	HA-1004 is a inhibitor of PKG, PKA, PKC and MLC.
T10549	Bisindolylmaleimide VIII acetate	138516-31-1	99%
T10549	Bisindolylmaleimide VIII acetate is a potent and selective PKC inhibitor (IC50: 158 nM for rat brain PKC). It has IC50s of 53, 195, 163, 213, and 175 nM for PKC-...
T2S0531	Pinoresinol dimethyl ether	29106-36-3	98.98%
T2S0531	Pinoresinol dimethyl ether is a natural product for research related to life sciences. The catalog number is T2S0531 and the CAS number is 29106-36-3.
T35827L	PKCε Inhibitor Peptide acetate		98.93%
T35827L	PKCε Inhibitor Peptide acetate is a selective PKCε inhibitor containing the site for its specific receptor for activated C kinase (RACK). PKCε Inhibitor Peptide ...
TN1299	Desmethylglycitein	17817-31-1	98.93%
TN1299	6,7,4'-Trihydroxyisoflavone, is a novel inhibitor of PKCα in suppressing solar UV-induced matrix metalloproteinase 1, which has antioxidant, and anti-cancer acti...