PI3K

Phosphoinositide 3-kinases (PI3Ks), also called phosphatidylinositol 3-kinases, are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer.PI3Ks are a family of related intracellular signal transducer enzymes capable of phosphorylating the 3 position hydroxyl group of the inositol ring of phosphatidylinositol (PtdIns). The pathway, with oncogene PIK3CA and tumor suppressor PTEN, is implicated in the sensitivity of cancer tumors to insulin and IGF1, and in calorie restriction.

Cat. No.	Product name	CAS No.	Purity
T2084	ETP-46464	1345675-02-6	99.56%
T2084	ETP-46464 is an effective and specific ATR inhibitor (IC50: 25 nM).
T5432	Eganelisib	1693758-51-8	99.56%
T5432	Eganelisib (IPI-549) is an inhibitor of PI3Kγ (IC50 = 16, 3,200, 3,500, and >8,400 nM for PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ, respectively)
T4S1796	Heterophyllin B	145459-19-4	99.55%
T4S1796	Heterophyllin B effectively suppresses the adhesion and invasion of the human esophageal carcinoma cells by mediating the PI3K/AKT/β-catenin pathways and regulat...
T35530	IHMT-PI3Kδ-372	2429889-62-1	99.54%
T35530	IHMT-PI3Kδ-372 is a selective inhibitor of PI3Kδ with an IC50 of 14 nM and can be used in studies about chronic obstructive pulmonary disease.
T6938	PF-4989216	1276553-09-3	99.53%
T6938	PF-4989216 is a potent and selective PI3K inhibitor with IC50 of 2 nM, 142 nM, 65 nM, 1 nM, and 110 nM for p110α, p110β, p110γ, p110δ, and VPS34, respectively.
T1916	Apitolisib	1032754-93-0	99.52%
T1916	Apitolisib (RG 7422), an effective, class I PI3K inhibitor for PI3Kα(IC50=5 nM), PI3Kβ(IC50=27 nM), PI3Kδ(IC50=7 nM), PI3Kγ (IC50=14 nM), is used in trials study...
T3153	Serabelisib	1268454-23-4	99.5%
T3153	Serabelisib (INK1117) is a p110α/β/γ/δ inhibitor (IC50: 15/4.5/1.9/13.39 μM).
TQ0229	ETP-46321	1252594-99-2	99.47%
TQ0229	ETP-46321 is an effective and orally bioavailable PI3Kα/PI3Kδ inhibitor (Ki: 2.3/14.2 nM).
T2308	HS-173	1276110-06-5	99.47%
T2308	HS-173 is an effective PI3Kα inhibitor (IC50: 0.8 nM).
T2377	Pilaralisib analogue	956958-53-5	99.46%
T2377	Pilaralisib analogue (XL147 analogue) is a selective and reversible class I PI3K inhibitor for PI3Kα/δ/γ.
T1999	Taselisib	1282512-48-4	99.46%
T1999	Taselisib (GDC-0032) is an orally bioavailable inhibitor of the class I phosphatidylinositol 3-kinase (PI3K) alpha isoform (PIK3CA), with potential antineoplasti...
T0579	Myricetin	529-44-2	99.45%
T0579	Myricetin (Cannabiscetin) is a naturally-occurring flavonoid found in many grapes, berries, fruits, vegetables, herbs, as well as other plants. Walnuts are a ric...
T21992	Vacuolin-1	351986-85-1	99.45%
T21992	Vacuolin-1 is a cell-permeable inhibitor of Ca2+ dependent fusion of lysosomes to the cell membrane. It acts by inhibiting release of lysosomal content.vacuolin‐...
T1949	CZC24832	1159824-67-5	99.45%
T1949	CZC24832 is a selective inhibitor of PI 3-kinase γ.
T1988	Duvelisib	1201438-56-3	99.45%
T1988	Duvelisib (INK1197) is an orally bioavailable, highly selective and potent small molecule inhibitor of the delta and gamma isoforms of phosphoinositide-3 kinase ...
T13376	YS-49	132836-42-1	99.42%
T13376	YS-49 is an activator of PI3K/Akt (a downstream target of RhoA).
T6845	GNE-317	1394076-92-6	99.42%
T6845	GNE-317, a PI3K/mTOR inhibitor, can pass through the blood-brain barrier (BBB).
T3351	Onatasertib	1228013-30-6	99.41%
T3351	Onatasertib (CC223) is an orally available mTOR inhibitor with potential antitumor activity. Onatasertib inhibits the activity of mTOR, which may result in the i...
T28416	PIK-108	901398-68-3	99.4%
T28416	PIK-108 is an allosteric inhibitor of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunits β and δ (PI3Kβ/δ).
T6030	XL388	1251156-08-7	99.39%
T6030	XL388 is a highly effective, specifc, ATP-competitive inhibitor of mTOR ( IC50: 9.9 nM), 1000-fold selectivity than the closely related PI3K kinases.