PI3K

Phosphoinositide 3-kinases (PI3Ks), also called phosphatidylinositol 3-kinases, are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer.PI3Ks are a family of related intracellular signal transducer enzymes capable of phosphorylating the 3 position hydroxyl group of the inositol ring of phosphatidylinositol (PtdIns). The pathway, with oncogene PIK3CA and tumor suppressor PTEN, is implicated in the sensitivity of cancer tumors to insulin and IGF1, and in calorie restriction.

Cat. No.	Product name	CAS No.	Purity
TQ0003	740 Y-P	1236188-16-1	98.3%
TQ0003	740 Y-P (740YPDGFR) is a potent and cell-permeable activator of PI3K.
T6168	ZSTK474	475110-96-4	98.29%
T6168	PI3K Inhibitor ZSTK474 is an orally available, s-triazine derivative, ATP-competitive phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplasti...
T4958	(-)-Alkannin	517-88-4	98.28%
T4958	(-)-Alkannin (Shikonin) is a natural red naphthoquinone pigment, has antimicrobial, anti-tumor, and anti-inflammatory effects; a purified shikonin preparation is...
T6817	Deguelin	522-17-8	98.26%
T6817	Deguelin ((-)-Deguelin) is a PI3K/AKT Inhibitor, which is a natural product isolated from plants in the Mundulea sericea family.
T2365	Pilaralisib	934526-89-3	98.24%
T2365	Pilaralisib (XL-147) is an orally available small molecule that selectively inhibits the activity of phosphoinositide-3 kinase (PI3K). Pilaralisib has been used ...
T12469	PI4KIIIbeta-IN-9	1429624-84-9	98.22%
T12469	PI4KIIIbeta-IN-9 is a potent inhibitor of PI4KIIIβ(IC50 of 7 nM). .
T6945	Vps34-PIK-III	1383716-40-2	98.21%
T6945	Vps34-PIK-III (VPS34-IN2), a selective inhibitor of VPS34 enzymatic activity, inhibits autophagy and results in the stabilization of autophagy substrates.
T3P2904	α-Linolenic acid	463-40-1	98.19%
T3P2904	α-Linolenic acid (Alpha-Linolenic Acid) is an essential fatty acid belonging to the omega-3 fatty acids group. It is highly concentrated in certain plant oils an...
T6704	TG 100713	925705-73-3	98.17%
T6704	TG 100713 is a pan-PI3K inhibitor against PI3Kγ, PI3Kδ, PI3Kα and PI3Kβ with IC50 of 50 nM, 24 nM, 165 nM and 215 nM, respectively.
T22430	SRX3207	2254693-15-5	98.14%
T22430	SRX3207 is an inhibitor of Syk and PI3K and relieves tumor immunosuppression.
TN1461	(-)-Butin	492-14-8	98.07%
TN1461	(-)-Butin (Butin) has antioxidant activity, can protect cells against H2O2-induced apoptosis, oxidative DNA damage and oxidative mitochondrial dysfunction; it at...
T3986	SF2523	1174428-47-7	98.06%
T3986	SF2523 is a highly selective and potent inhibitor.
T2174	Quercetin	117-39-5	98.05%
T2174	Quercetin (Sophoretin) is a natural flavonoid and is an agonist of SIRT1. Quercetin is also a PI3K inhibitor, inhibiting PI3Kγ, PI3Kδ, and PI3Kβ (IC50=2.4/3.0/5....
T2357	GSK1059615	958852-01-2	98%
T2357	GSK1059615 has been used in trials studying the treatment of Lymphoma, Solid Tumours, Endometrial Cancer, Solid Tumor Cancer, and Metastatic Breast Cancer.
T3705	GDC0084	1382979-44-3	98%
T3705	GDC0084 (RG7666) is a PI3K inhibitor with potential antineoplastic activity. GDC0084 (RG7666) specifically inhibits PI3K in the PI3K/AKT kinase (or protein kinas...
T2287	PIK-75 hydrochloride	372196-77-5	98%
T2287	PIK-75 hydrochloride (PIK-75 HCl) is a p110α inhibitor with IC50 of 5.8 nM (200-fold more potently than p110β), isoform-specific mutants at Ser773, and also pote...
T5831	Selective PI3Kδ Inhibitor 1	2088525-31-7	98%
T5831	Selective PI3Kδ Inhibitor 1 is a PI3Kδ Inhibitor( IC50 = 0.9 nM).
T2461	PIK-90	677338-12-4	98%
T2461	PIK-90, a DNA-PK and PI3K inhibitor, suppresses p110α( IC50=11 nM), p110γ(IC50=18 nM) and DNA-PK(IC50=13 nM) .
T6330	Linperlisib	1702816-75-8	98%
T6330	Linperlisib (PI3Kδ-IN-2) is a potent and selective inhibitor of PI3Kδ
T2083	PI-3065	955977-50-1	98%
T2083	PI-3065 is a novel potent and selective PI3K p110δ inhibitor.