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PDGFR

Platelet-derived growth factor receptors (PDGF-R) are cell surface tyrosine kinase receptors for members of the platelet-derived growth factor (PDGF) family. PDGF subunits -A and -B are important factors regulating cell proliferation, cellular differentiation, cell growth, development and many diseases including cancer. There are two forms of the PDGF-R, alpha and beta each encoded by a different gene. Depending on which growth factor is bound, PDGF-R homo- or heterodimerizes.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T1886 TAK-632 1228591-30-7 98.92%
TAK-632
TAK-632 is a potent pan-Raf inhibitor.
TN1969 N-(p-Coumaroyl) serotonin 68573-24-0 98.78%
N-(p-Coumaroyl) serotonin
N-(p-Coumaroyl) Serotonin is a polyphenol isolated from the seeds of safflower. N-(p-Coumaroyl) serotonin has antioxidant, cardioprotective effects after ischemi...
T8491 Vorolanib 1013920-15-4 98.73%
Vorolanib
Vorolanib (X-82) is an orally active VEGFR/PDGFR dual inhibitor.
T11641 N-Desmethyl imatinib 404844-02-6 98.60%
N-Desmethyl imatinib
N-Desmethyl imatinib (Imatinib metabolite N-Desmethyl imatinib) is a metabolite of Imatinib, which is a multi-target inhibitor of c-Kit, v-Abl, and PDGFR.
T15616 JNJ-10198409 627518-40-5 98.51%
JNJ-10198409
JNJ- 10198409 is a relatively selective and ATP competitive PDGF-RTK inhibitor (IC50=2 nM). JNJ-10198409 has good activity against PDGFR-β kinase (IC50=4.2 nM) a...
T10870L CP-547632 252003-65-9 98.51%
CP-547632
CP-547632 is an orally available and potent, ATP-competitive dual inhibitor of VEGFR-2 and FGF kinase F with IC50s of 11 nM and 9 nM, respectively. CP-547632 is ...
T2516 Amuvatinib 850879-09-3 98.48%
Amuvatinib
Amuvatinib (MP470) is an orally bioavailable synthetic carbothioamide with potential antineoplastic activity.
T2677 Crenolanib 670220-88-9 98.40%
Crenolanib
Crenolanib (ARO 002) is an orally bioavailable type III tyrosine kinases inhibitor of PDGFRα/β and FLT3 (IC50s: 11, 3.2, and 4 nM).
T6350 CHIR-124 405168-58-3 98.35%
CHIR-124
CHIR-124 is an effective Chk1 inhibitor (IC50: 0.3 nM). It has 2, 000-fold selectivity against Chk2, 500- to 5, 000-fold less activity against Cdc2 and CDK2/4.
T0374 Sunitinib Malate 341031-54-7 98.23%
Sunitinib Malate
Sunitinib Malate (Sunitinib) is an indolinone-based tyrosine kinase inhibitor. It blocks the tyrosine kinase activities of VEGFR2, PDGFRβ (IC50: 80/2 nM), and c-...
T2456 Tivozanib 475108-18-0 98.23%
Tivozanib
Tivozanib (KRN951) is an orally bioavailable inhibitor of vascular endothelial growth factor receptors (VEGFRs) 1, 2 and 3 with potential antiangiogenic and anti...
T0374L Sunitinib 557795-19-4 98.22%
Sunitinib
Sunitinib (SU 11248), a multi-targeted RTK inhibitor, is targeting PDGFRβ and VEGFR2 (Flk-1) with IC50 of 2 nM and 80 nM and also inhibits c-Kit.
T41003 KG5 877874-85-6 98.2%
KG5
KG5 is a dual allosteric inhibitor of PDGFRβ and B-Raf with a Kd of 520 nM and 300 nM for PDGFRβ and PDGFRα. KG5 inhibits FLT3, KIT, and c-Raf with anticancer an...
TQ0059 Ilorasertib 1227939-82-3 98.03%
Ilorasertib
Ilorasertib (ABT-348) (ABT-348) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora A/Aurora B/Aurora C (IC50s: 120 nM/7 nM/1 nM). It als...
T10157 Regorafénib N-oxyde (M2) 835621-11-9 98.03%
Regorafénib N-oxyde (M2)
Regorafénib N-oxyde M2 is an active metabolite of Regorafenib. Regorafenib is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, RET, Kit, and Raf-1 (IC50s: 13/4.2...
T2358 ENMD-2076 934353-76-1 98%
ENMD-2076
ENMD-2076, a multi-targeted kinase inhibitor, has specific activity against Aurora A, Flt3, KDR/VEGFR2, Flt4/VEGFR3, FGFR1, FGFR2, Src, PDGFRα.
T7394 Toceranib Phosphate 874819-74-6 98%
Toceranib Phosphate
Toceranib Phosphate (SU11654 phosphate), is a selective inhibitor of the tyrosine kinase activity of several members of the split kinase RTK family, including Fl...
T2514 Linifanib 796967-16-3 98%
Linifanib
Linifanib (AL-39324) (ABT-869) is a novel, potent ATP-competitive VEGFR/PDGFR inhibitor for KDR (IC50: 4 nM), CSF-1R (IC50: 3 nM), Flt-1/3 (IC50: 3/4 nM) and PDG...
T1836 AZD2932 883986-34-3 97.71%
AZD2932
AZD2932 is a potent and multi-targeted kinase inhibitor VEGFR2, PDGFβ, Flt-3, and c-Kit.
T13238 Tyrphostin AG1433 168835-90-3 97.51%
Tyrphostin AG1433
Tyrphostin AG1433 (AG1433) is an inhibitor of tyrosine kinases and also a dual inhibitor of PDGFRβ(IC50s = 5.0 μM) and VEGFR-2 (Flk-1/KDR)(IC50s = 9.3 μM).
TAK-632
T1886
TAK-632 is a potent pan-Raf inhibitor.
N-(p-Coumaroyl) serotonin
TN1969
N-(p-Coumaroyl) Serotonin is a polyphenol isolated from the seeds of safflower. N-(p-Coumaroyl) serotonin has antioxidant, cardioprotective effects after ischemi...
Vorolanib
T8491
Vorolanib (X-82) is an orally active VEGFR/PDGFR dual inhibitor.
N-Desmethyl imatinib
T11641
N-Desmethyl imatinib (Imatinib metabolite N-Desmethyl imatinib) is a metabolite of Imatinib, which is a multi-target inhibitor of c-Kit, v-Abl, and PDGFR.
JNJ-10198409
T15616
JNJ- 10198409 is a relatively selective and ATP competitive PDGF-RTK inhibitor (IC50=2 nM). JNJ-10198409 has good activity against PDGFR-β kinase (IC50=4.2 nM) a...
CP-547632
T10870L
CP-547632 is an orally available and potent, ATP-competitive dual inhibitor of VEGFR-2 and FGF kinase F with IC50s of 11 nM and 9 nM, respectively. CP-547632 is ...
Amuvatinib
T2516
Amuvatinib (MP470) is an orally bioavailable synthetic carbothioamide with potential antineoplastic activity.
Crenolanib
T2677
Crenolanib (ARO 002) is an orally bioavailable type III tyrosine kinases inhibitor of PDGFRα/β and FLT3 (IC50s: 11, 3.2, and 4 nM).
CHIR-124
T6350
CHIR-124 is an effective Chk1 inhibitor (IC50: 0.3 nM). It has 2, 000-fold selectivity against Chk2, 500- to 5, 000-fold less activity against Cdc2 and CDK2/4.
Sunitinib Malate
T0374
Sunitinib Malate (Sunitinib) is an indolinone-based tyrosine kinase inhibitor. It blocks the tyrosine kinase activities of VEGFR2, PDGFRβ (IC50: 80/2 nM), and c-...
Tivozanib
T2456
Tivozanib (KRN951) is an orally bioavailable inhibitor of vascular endothelial growth factor receptors (VEGFRs) 1, 2 and 3 with potential antiangiogenic and anti...
Sunitinib
T0374L
Sunitinib (SU 11248), a multi-targeted RTK inhibitor, is targeting PDGFRβ and VEGFR2 (Flk-1) with IC50 of 2 nM and 80 nM and also inhibits c-Kit.
KG5
T41003
KG5 is a dual allosteric inhibitor of PDGFRβ and B-Raf with a Kd of 520 nM and 300 nM for PDGFRβ and PDGFRα. KG5 inhibits FLT3, KIT, and c-Raf with anticancer an...
Ilorasertib
TQ0059
Ilorasertib (ABT-348) (ABT-348) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora A/Aurora B/Aurora C (IC50s: 120 nM/7 nM/1 nM). It als...
Regorafénib N-oxyde (M2)
T10157
Regorafénib N-oxyde M2 is an active metabolite of Regorafenib. Regorafenib is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, RET, Kit, and Raf-1 (IC50s: 13/4.2...
ENMD-2076
T2358
ENMD-2076, a multi-targeted kinase inhibitor, has specific activity against Aurora A, Flt3, KDR/VEGFR2, Flt4/VEGFR3, FGFR1, FGFR2, Src, PDGFRα.
Toceranib Phosphate
T7394
Toceranib Phosphate (SU11654 phosphate), is a selective inhibitor of the tyrosine kinase activity of several members of the split kinase RTK family, including Fl...
Linifanib
T2514
Linifanib (AL-39324) (ABT-869) is a novel, potent ATP-competitive VEGFR/PDGFR inhibitor for KDR (IC50: 4 nM), CSF-1R (IC50: 3 nM), Flt-1/3 (IC50: 3/4 nM) and PDG...
AZD2932
T1836
AZD2932 is a potent and multi-targeted kinase inhibitor VEGFR2, PDGFβ, Flt-3, and c-Kit.
Tyrphostin AG1433
T13238
Tyrphostin AG1433 (AG1433) is an inhibitor of tyrosine kinases and also a dual inhibitor of PDGFRβ(IC50s = 5.0 μM) and VEGFR-2 (Flk-1/KDR)(IC50s = 9.3 μM).
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TargetMol