T9773 |
Thioquinapiperifil dihydrochloride
|
204077-66-7
|
98.73%
|
|
Thioquinapiperifil dihydrochloride is a phosphodiesterase (PDE-5) inhibitor (IC50: 0.074 nM) that is potent, selective and non-competitive for investigational ma...
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T21865 |
BC 11-38
|
686770-80-9
|
98.72%
|
|
BC 11-38 is a potent, selective PDE biodepressant which is mainly effective against PDE11 (IC50 : 0.28 μM).
|
T13331 |
WAY127093B racemate
|
145743-63-1
|
98.63%
|
|
WAY127093B racemate is the racemate of WAY127093B. WAY127093B is a phosphodiesterase IV inhibitor with oral activity in rats and guinea pigs.
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T10201 |
PDE IV-IN-1
|
225100-12-9
|
98.57%
|
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PDE IV-IN-1 is a potent phosphodiesterase 4 (PDE4) inhibitor with anti-inflammatory activity for the treatment of asthma, chronic obstructive pulmonary disease a...
|
T2855 |
Icariin
|
489-32-7
|
98.49%
|
|
Icariin (Ieariline) is a flavonol glycoside, inhibiting PDE5 and PDE4 activities. Icariin also is a PPARα activator.
|
T13189 |
TP-10
|
898563-00-3
|
98.48%
|
|
TP-10 is a selective inhibitor of PDE10A against other PDEs with IC50 of 0.8 nM.
|
T25376 |
Ensifentrine
|
1884461-72-6
|
98.45%
|
|
Ensifentrine (Ensifentrinum) is a PDE3/4 inhibitor, although its affinity for PDE3(IC50: 0.4 nM) is 3,440 times higher than that for PDE4(IC50: 1479 nM), that is...
|
TN3091 |
5,7-Diacetoxy-8-methoxyflavone
|
23246-80-2
|
98.45%
|
|
5,7-Diacetoxy-8-methoxyflavone is derived from the roots of Scutellaria baicalensis and inhibits cAMP phosphodiesterase.
|
TN4510 |
(+)-Medioresinol Di-O-β-D-glucopyranoside
|
88142-63-6
|
98.45%
|
|
(+)-Medioresinol Di-O-β-D-glucopyranoside has strong inhibitory activity of cyclic AMP phosphodiesterase.
|
T3987 |
Lotamilast
|
947620-48-6
|
98.44%
|
|
Lotamilast (RVT-501) is a phosphodiesterase 4 (PDE-4) inhibitor (IC50: 2.8 nM) potentially for the treatment of atopic dermatitis.
|
T23411L |
T-0156
|
324572-92-1
|
98.42%
|
|
T-0156 is a novel, potent and selective phosphodiesterase type 5 inhibitor that inhibits the hydrolysis of cyclic guanosine monophosphate (cGMP) with low affinit...
|
T38625 |
Tanimilast
|
1239278-59-1
|
98.34%
|
|
Tanimilast (CHF-6001) is a novel, potent and selective phosphodiesterase 4 inhibitor with an IC 50 value of 0.026 ± 0.006 nM.Tanimilast has potent anti-inflammat...
|
T11533 |
Z-HA155
|
1312201-00-5
|
98.28%
|
|
Z-HA155 (CS-963) selectively and potently inhibits autotaxin with an IC50 of 5.7 nM.
|
T5496 |
ML-030
|
1013750-77-0
|
98.24%
|
|
ML-030 is a potent and selective inhibitor of PDE4(PDE4A, PDE4A1, PDE4B1, PDE4B2, PDE4C1,and PDE4D2 with IC50 of 6.7 nM, 12.9 nM, 48.2 nM, 37.2 nM, 452 nM and 49...
|
T11689 |
ITI-214
|
1642303-38-5
|
98.21%
|
|
ITI-214 is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters, and io...
|
T61833 |
Tovinontrine
|
2062661-53-2
|
98.14%
|
|
Tovinontrine (IMR-687) (IMR-687) is a potent and selective inhibitor of phosphodiesterase-9 (PDE9), designed to target sickle cell disease treatment. It exhibits...
|
T2923 |
Apremilast
|
608141-41-9
|
98.13%
|
|
Apremilast (CC-10004) (CC-10004) is a potent and orally active PDE4 (IC50=74 nM) with anti-inflammation activities.
|
T3465 |
Vesnarinone
|
81840-15-5
|
98.13%
|
|
Vesnarinone (Arkin) (INN) is a mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest, dose-dependent, positive inotropic activity, but min...
|
T16379 |
Oglemilast
|
778576-62-8
|
98.11%
|
|
Oglemilast (GRC 3886) suppresses pulmonary cell infiltration, including eosinophilia and neutrophilia in vitro and in vivo. Oglemilast is an effective and orally...
|
T72031 |
BI 1015550
|
1423719-30-5
|
98.06%
|
|
BI 1015550 is an orally active inhibitor of PDE4B with an IC 50 value of 7.2 nM. BI 1015550 has good safety and potential applications in inflammation, allergic ...
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