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PDE

A phosphodiesterase (PDE) is an enzyme that breaks a phosphodiester bond. Usually, phosphodiesterase refers to cyclic nucleotide phosphodiesterases, which have great clinical significance and are described below. However, there are many other families of phosphodiesterases, including phospholipases C and D, autotaxin, sphingomyelin phosphodiesterase, DNases, RNases, and restriction endonucleases (which all break the phosphodiester backbone of DNA or RNA), as well as numerous less-well-characterized small-molecule phosphodiesterases.The cyclic nucleotide phosphodiesterases comprise a group of enzymes that degrade the phosphodiester bond in the second messenger molecules cAMP and cGMP. They regulate the localization, duration, and amplitude of cyclic nucleotide signaling within subcellular domains. PDEs are therefore important regulators of signal transduction mediated by these second messenger molecules.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T9773 Thioquinapiperifil dihydrochloride 204077-66-7 98.73%
Thioquinapiperifil dihydrochloride
Thioquinapiperifil dihydrochloride is a phosphodiesterase (PDE-5) inhibitor (IC50: 0.074 nM) that is potent, selective and non-competitive for investigational ma...
T21865 BC 11-38 686770-80-9 98.72%
BC 11-38
BC 11-38 is a potent, selective PDE biodepressant which is mainly effective against PDE11 (IC50 : 0.28 μM).
T13331 WAY127093B racemate 145743-63-1 98.63%
WAY127093B racemate
WAY127093B racemate is the racemate of WAY127093B. WAY127093B is a phosphodiesterase IV inhibitor with oral activity in rats and guinea pigs.
T10201 PDE IV-IN-1 225100-12-9 98.57%
PDE IV-IN-1
PDE IV-IN-1 is a potent phosphodiesterase 4 (PDE4) inhibitor with anti-inflammatory activity for the treatment of asthma, chronic obstructive pulmonary disease a...
T2855 Icariin 489-32-7 98.49%
Icariin
Icariin (Ieariline) is a flavonol glycoside, inhibiting PDE5 and PDE4 activities. Icariin also is a PPARα activator.
T13189 TP-10 898563-00-3 98.48%
TP-10
TP-10 is a selective inhibitor of PDE10A against other PDEs with IC50 of 0.8 nM.
T25376 Ensifentrine 1884461-72-6 98.45%
Ensifentrine
Ensifentrine (Ensifentrinum) is a PDE3/4 inhibitor, although its affinity for PDE3(IC50: 0.4 nM) is 3,440 times higher than that for PDE4(IC50: 1479 nM), that is...
TN3091 5,7-Diacetoxy-8-methoxyflavone 23246-80-2 98.45%
5,7-Diacetoxy-8-methoxyflavone
5,7-Diacetoxy-8-methoxyflavone is derived from the roots of Scutellaria baicalensis and inhibits cAMP phosphodiesterase.
TN4510 (+)-Medioresinol Di-O-β-D-glucopyranoside 88142-63-6 98.45%
(+)-Medioresinol Di-O-β-D-glucopyranoside
(+)-Medioresinol Di-O-β-D-glucopyranoside has strong inhibitory activity of cyclic AMP phosphodiesterase.
T3987 Lotamilast 947620-48-6 98.44%
Lotamilast
Lotamilast (RVT-501) is a phosphodiesterase 4 (PDE-4) inhibitor (IC50: 2.8 nM) potentially for the treatment of atopic dermatitis.
T23411L T-0156 324572-92-1 98.42%
T-0156
T-0156 is a novel, potent and selective phosphodiesterase type 5 inhibitor that inhibits the hydrolysis of cyclic guanosine monophosphate (cGMP) with low affinit...
T38625 Tanimilast 1239278-59-1 98.34%
Tanimilast
Tanimilast (CHF-6001) is a novel, potent and selective phosphodiesterase 4 inhibitor with an IC 50 value of 0.026 ± 0.006 nM.Tanimilast has potent anti-inflammat...
T11533 Z-HA155 1312201-00-5 98.28%
Z-HA155
Z-HA155 (CS-963) selectively and potently inhibits autotaxin with an IC50 of 5.7 nM.
T5496 ML-030 1013750-77-0 98.24%
ML-030
ML-030 is a potent and selective inhibitor of PDE4(PDE4A, PDE4A1, PDE4B1, PDE4B2, PDE4C1,and PDE4D2 with IC50 of 6.7 nM, 12.9 nM, 48.2 nM, 37.2 nM, 452 nM and 49...
T11689 ITI-214 1642303-38-5 98.21%
ITI-214
ITI-214 is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters, and io...
T61833 Tovinontrine 2062661-53-2 98.14%
Tovinontrine
Tovinontrine (IMR-687) (IMR-687) is a potent and selective inhibitor of phosphodiesterase-9 (PDE9), designed to target sickle cell disease treatment. It exhibits...
T2923 Apremilast 608141-41-9 98.13%
Apremilast
Apremilast (CC-10004) (CC-10004) is a potent and orally active PDE4 (IC50=74 nM) with anti-inflammation activities.
T3465 Vesnarinone 81840-15-5 98.13%
Vesnarinone
Vesnarinone (Arkin) (INN) is a mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest, dose-dependent, positive inotropic activity, but min...
T16379 Oglemilast 778576-62-8 98.11%
Oglemilast
Oglemilast (GRC 3886) suppresses pulmonary cell infiltration, including eosinophilia and neutrophilia in vitro and in vivo. Oglemilast is an effective and orally...
T72031 BI 1015550 1423719-30-5 98.06%
BI 1015550
BI 1015550 is an orally active inhibitor of PDE4B with an IC 50 value of 7.2 nM. BI 1015550 has good safety and potential applications in inflammation, allergic ...
Thioquinapiperifil dihydrochloride
T9773
Thioquinapiperifil dihydrochloride is a phosphodiesterase (PDE-5) inhibitor (IC50: 0.074 nM) that is potent, selective and non-competitive for investigational ma...
BC 11-38
T21865
BC 11-38 is a potent, selective PDE biodepressant which is mainly effective against PDE11 (IC50 : 0.28 μM).
WAY127093B racemate
T13331
WAY127093B racemate is the racemate of WAY127093B. WAY127093B is a phosphodiesterase IV inhibitor with oral activity in rats and guinea pigs.
PDE IV-IN-1
T10201
PDE IV-IN-1 is a potent phosphodiesterase 4 (PDE4) inhibitor with anti-inflammatory activity for the treatment of asthma, chronic obstructive pulmonary disease a...
Icariin
T2855
Icariin (Ieariline) is a flavonol glycoside, inhibiting PDE5 and PDE4 activities. Icariin also is a PPARα activator.
TP-10
T13189
TP-10 is a selective inhibitor of PDE10A against other PDEs with IC50 of 0.8 nM.
Ensifentrine
T25376
Ensifentrine (Ensifentrinum) is a PDE3/4 inhibitor, although its affinity for PDE3(IC50: 0.4 nM) is 3,440 times higher than that for PDE4(IC50: 1479 nM), that is...
5,7-Diacetoxy-8-methoxyflavone
TN3091
5,7-Diacetoxy-8-methoxyflavone is derived from the roots of Scutellaria baicalensis and inhibits cAMP phosphodiesterase.
(+)-Medioresinol Di-O-β-D-glucopyranoside
TN4510
(+)-Medioresinol Di-O-β-D-glucopyranoside has strong inhibitory activity of cyclic AMP phosphodiesterase.
Lotamilast
T3987
Lotamilast (RVT-501) is a phosphodiesterase 4 (PDE-4) inhibitor (IC50: 2.8 nM) potentially for the treatment of atopic dermatitis.
T-0156
T23411L
T-0156 is a novel, potent and selective phosphodiesterase type 5 inhibitor that inhibits the hydrolysis of cyclic guanosine monophosphate (cGMP) with low affinit...
Tanimilast
T38625
Tanimilast (CHF-6001) is a novel, potent and selective phosphodiesterase 4 inhibitor with an IC 50 value of 0.026 ± 0.006 nM.Tanimilast has potent anti-inflammat...
Z-HA155
T11533
Z-HA155 (CS-963) selectively and potently inhibits autotaxin with an IC50 of 5.7 nM.
ML-030
T5496
ML-030 is a potent and selective inhibitor of PDE4(PDE4A, PDE4A1, PDE4B1, PDE4B2, PDE4C1,and PDE4D2 with IC50 of 6.7 nM, 12.9 nM, 48.2 nM, 37.2 nM, 452 nM and 49...
ITI-214
T11689
ITI-214 is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters, and io...
Tovinontrine
T61833
Tovinontrine (IMR-687) (IMR-687) is a potent and selective inhibitor of phosphodiesterase-9 (PDE9), designed to target sickle cell disease treatment. It exhibits...
Apremilast
T2923
Apremilast (CC-10004) (CC-10004) is a potent and orally active PDE4 (IC50=74 nM) with anti-inflammation activities.
Vesnarinone
T3465
Vesnarinone (Arkin) (INN) is a mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest, dose-dependent, positive inotropic activity, but min...
Oglemilast
T16379
Oglemilast (GRC 3886) suppresses pulmonary cell infiltration, including eosinophilia and neutrophilia in vitro and in vivo. Oglemilast is an effective and orally...
BI 1015550
T72031
BI 1015550 is an orally active inhibitor of PDE4B with an IC 50 value of 7.2 nM. BI 1015550 has good safety and potential applications in inflammation, allergic ...
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TargetMol