T4041 |
Ziritaxestat
|
1628260-79-6
|
99.67%
|
|
Ziritaxestat (GLPG1690), an autotaxin inhibitor, currently being evaluated in an exploratory phase 2 study in idiopathic pulmonary fibrosis patients.
|
T9871 |
Dazonone
|
105622-85-3
|
99.67%
|
|
Dazonone (Imidazo[2,1-b]quinazolin-2(3H)-one, 6-chloro-1,5-dihydro-3-methyl-) is a specific PDE III inhibitors.
|
T2334 |
Avanafil
|
330784-47-9
|
99.66%
|
|
Avanafil (TA1790) is a selective inhibitor of phosphodiesterase type 5 (PDE5) and is used as therapy of erectile dysfunction.
|
T6054 |
GSK256066
|
801312-28-7
|
99.66%
|
|
GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380, 000-fold selectivity versus PDE1/2/3/5/6 and >2500-fold selec...
|
T4462 |
Roflumilast N-oxide
|
292135-78-5
|
99.65%
|
|
Roflumilast N-oxide is an inhibitor of PDE type 4.
|
T5101 |
BW-A 78U
|
101155-02-6
|
99.65%
|
|
BW-A 78U is a PDE4 inhibitor (IC50: 3 μM). It is not inhibition on the lipopolysaccharide (LPS)-induced TNF-α release.
|
T1083 |
Theophylline
|
58-55-9
|
99.65%
|
|
Theophylline (1,3-Dimethylxanthine) is a methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervo...
|
T28881 |
Sulmazole
|
73384-60-8
|
99.64%
|
|
Sulmazole (AR-L 115-BS) is a small molecule Sulmazole is a small molecule cGMP-PDE inhibitor.Sulmazole is a competitive inhibitor of A1 adenosine receptors.Sulma...
|
T1024 |
Roflumilast
|
162401-32-3
|
99.64%
|
|
Roflumilast (APTA 2217) is an orally available, long-acting inhibitor of phosphodiesterase (PDE) type 4 (PDE4), with anti-inflammatory and potential antineoplast...
|
T31792 |
Filaminast
|
141184-34-1
|
99.64%
|
|
Filaminast (UNII-CDD69JC61J) is an analog of a phosphodiesterase 4 inhibitor (PDE4 inhibitor) and roliplam, which is used as an anti-asthma drug.
|
T0705 |
Triflusal
|
322-79-2
|
99.61%
|
|
Triflusal (UR1501) is a 2-acetoxy-4-trifluoromethylbenzoic acid and it is an aspirin chemically-related molecule but not a derivative.
|
T0467 |
Sildenafil citrate
|
171599-83-0
|
99.59%
|
|
Sildenafil citrate (UK-92480 citrate) , a cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) Inhibitor, is used extensively for erect...
|
T23256 |
RS-25344 hydrochloride
|
152815-28-6
|
99.58%
|
|
RS 25344 hydrochloride is a phosphodiesterase (PDE) 4 inhibitor
|
T1418 |
Bucladesine sodium
|
16980-89-5
|
99.58%
|
|
Bucladesine sodium (DC2797) is a cAMP analog with cell-permeable properties. Bucladesine sodium is also a cAMP-dependent protein kinase (PKA) activator and a pho...
|
T31020 |
CP 461
|
227619-96-7
|
99.57%
|
|
CP 461 (UNII-68OJX9I7DT), a specific PDE2A inhibitor, is a novel pro-apoptotic compound that inhibits cyclic GMP phosphodiesterase but not cyclooxygenase-1 or -2...
|
T35048 |
Verofylline
|
66172-75-6
|
99.55%
|
|
Verofylline (Verofyllinum) is an orally available, long-acting, multiacting, methylxanthine-substituted bronchodilator with inhibitory effects on PDE4 for the tr...
|
T19865 |
GEBR-7b
|
67387-76-2
|
99.54%
|
|
GEBR-7b (3-(Cyclopentyloxy)-4-methoxybenzaldehyde) is a phosphodiesterase-4 (PDE4) inhibitor.
|
T1398 |
Tadalafil
|
171596-29-5
|
99.53%
|
|
Tadalafil (IC-351) is a carboline-based compound with vasodilatory activity. Tadalafil selectively inhibits the cyclic guanosine monophosphate (cGMP)-specific ty...
|
T2646 |
HA130
|
1229652-21-4
|
99.52%
|
|
HA130 is a selective ATX (autotaxin) inhibitor.
|
T12315 |
OR-1896
|
220246-81-1
|
99.51%
|
|
OR-1896 is an active long-lived Levosimendan metabolite, is a highly selective inhibitor of phosphodiesterase (PDE) III isoformand a powerful vasodilator.
|