PDE

A phosphodiesterase (PDE) is an enzyme that breaks a phosphodiester bond. Usually, phosphodiesterase refers to cyclic nucleotide phosphodiesterases, which have great clinical significance and are described below. However, there are many other families of phosphodiesterases, including phospholipases C and D, autotaxin, sphingomyelin phosphodiesterase, DNases, RNases, and restriction endonucleases (which all break the phosphodiester backbone of DNA or RNA), as well as numerous less-well-characterized small-molecule phosphodiesterases.The cyclic nucleotide phosphodiesterases comprise a group of enzymes that degrade the phosphodiester bond in the second messenger molecules cAMP and cGMP. They regulate the localization, duration, and amplitude of cyclic nucleotide signaling within subcellular domains. PDEs are therefore important regulators of signal transduction mediated by these second messenger molecules.

Cat. No.	Product name	CAS No.	Purity
T8515	Osoresnontrine	1189767-28-9	99.82%
T8515	Osoresnontrine is a potent and selective inhibitor of PDE9A (IC50 of 52 nM),and can be used in the research of memory.
T16499	Mardepodect	898562-94-2	99.81%
T16499	Mardepodect (PF-2545920) is a phosphodiesterase inhibitor selective for the PDE10A subtype with an IC50 of 0.37 nM, >1000-fold selectivity over PDE. It is potent...
T1713	IBMX	28822-58-4	99.80%
T1713	IBMX (Methylisobutylxanthine) is a broad-spectrum phosphodiesterase (PDE) inhibitor with inhibitory activity against PDE3, PDE4, and PDE5 (IC50=6.5/26.3/31.7 μM)...
TN1950	Moracin M	56317-21-6	99.8%
TN1950	Moracin M, a phenolic compound found in the skin of Morus alba Linn., effectively inhibits phosphodiesterase-4 (PDE4), exhibiting IC50 values of 2.9 μM and 4.5 μ...
TN1266	3-O-Methylquercetin	1486-70-0	99.8%
TN1266	3-O-Methylquercetin is a selective and competitive PDE3/PDE4 inhibitor, and inhibits PDE3 than PDE4 with a low K(m) value; it inhibits total cAMP- and cGMP-phosp...
T1083L	Theophylline monohydrate	5967-84-0	99.79%
T1083L	Theophylline monohydrate (Quibron) appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calcium distributio...
T71691	Pumafentrine	207993-12-2	99.79%
T71691	Pumafentrine（BY 343） is a dual PDE3/PDE4 inhibitor that reduces clinical scores and TNF expression in experimental colitis in mice.
T5940	Proxyphylline	603-00-9	99.79%
T5940	Proxyphylline (7-(2-Hydroxypropyl)theophylline) is a dual of adenosine A1/A2a receptor inhibitor and phosphodiesterase (PDE) inhibitor. Proxyphylline acts as a c...
T1112	2-(Hydroxymethyl)pyridine	586-98-1	99.79%
T1112	2-(Hydroxymethyl)pyridine (Piconol) is used as an organic synthesis and medicinal chemistry intermediate for the synthesis of the stimulant laxative bisacodyl, a...
T6390	Anagrelide hydrochloride	58579-51-4	99.77%
T6390	Anagrelide hydrochloride (BL4162A) serves as a treatment for essential thrombocytosis.
T12913	Siguazodan	115344-47-3	99.77%
T12913	Siguazodan (SKF 94836) is an effective, selective, orally active phosphodiesterase III ((PDE-III)) inhibitor with an IC50 of 117 nM. Siguazodan inhibited phenyle...
T16164	MY-5445	78351-75-4	99.77%
T16164	MY-5445 (N-(3-chlorophenyl)-4-phenylphthalazin-1-amine) is a specific inhibitor of phosphodiesterase type 5 (PDE5). MY-5445 selectively inhibits cGMP PDE (Ki:1.3...
T20792	W-7 hydrochloride	61714-27-0	99.75%
T20792	W-7 hydrochloride (W-7 HCl), a calmodulin antagonist, inhibits Ca2+-calmodulin-dependent myosin light chain kinase and phosphodiesterase, W-7 hydrochloride induc...
T6548	Irsogladine	57381-26-7	99.74%
T6548	Irsogladine (Dicloguamine) is an anti-gastric ulcer agent that facilitates gap-junctional intercellular communication through M1 muscarininc acetylcholine recept...
T3224	TBA-7371	1494675-86-3	99.74%
T3224	TBA-7371 (DprE1-IN-1) is a potent inhibitor of DprE1 and PDE6.
T8659	K-Ras-PDEδ-IN-1	1841464-21-8	99.74%
T8659	K-Ras-PDEδ-IN-1 is a potent inhibitor of competitive K-Ras-PDEδ.It binds to the farnesyl binding pocket of PDEδ(Kd of 8 nM).
T2129	Zaprinast	37762-06-4	99.73%
T2129	Zaprinast is a cGMP-selective phosphodiesterase (PDE) inhibitor and a GPR35 agonist. It has a strong activating effect on rat GPR35 and a certain activating effe...
T6649	(S)-(+)-Rolipram	85416-73-5	99.71%
T6649	(S)-(+)-Rolipram ((+)-Rolipram) inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 μM, has anti-inflammatory and anti-depressant activity in the ...
T2530	Levosimendan	141505-33-1	99.7%
T2530	Levosimendan (OR1259) is a calcium sensitizer used in the management of acutely decompensated congestive heart failure. It increases the sensitivity of the heart...
T10841	CM-675	1872466-47-1	99.67%
T10841	CM-675 is a dual inhibitor of phosphodiesterase 5 (PDE5) and class I histone deacetylases (IC50s: 114 nM and 673 nM for PDE5 and HDAC1) with the potential to tre...