T62281 |
PARP-1-IN-2
|
684234-55-7
|
98.82%
|
|
PARP-1-IN-2 is a potent PARP1 inhibitor that crosses the blood-brain barrier (IC50: 149 nM).PARP-1-IN-2 showed significant antiproliferative activity against the...
|
T67844 |
RBN-3143
|
2360853-16-1
|
98.64%
|
|
RBN-3143 is a potent and inhibitor of NAD+-competitive catalytic PARP14 (IC50= 4 nM). RBN-3143 inhibits ADP-ribosylation mediated by PARP14 and stabilizes PARP14...
|
T9430 |
Venadaparib
|
1681017-83-3
|
98.47%
|
|
Venadaparib (NOV140101) (IDX-1197) is a potent, selective and orally active PARP inhibitor with IC50s of 1.4 nM and 1.0 nM for PARP1 and PARP2, respectively. Ven...
|
T8964 |
G244-LM
|
1563007-08-8
|
98.46%
|
|
G244-LM is a potent and specific inhibitor of tankyrase 1/2. G244-LM inhibits Wnt signaling.
|
T72437 |
PARP1/2/TNKS1/2-IN-1
|
2243453-32-7
|
98.40%
|
|
PARP1/2/TNKS1/2-IN-1 is a multi-target inhibitor of PARP-1, PARP-2, TNKS1 and TNKS2.PARP1/2/TNKS1/2-IN-1 has potential anti-tumor activity and induces apoptosis....
|
T77675 |
TNKS-2-IN-1
|
4765-59-7
|
98.4%
|
|
TNKS-2-IN-1 is a TNKS-2 inhibitor.TNKS-2-IN-1 inhibits TNKS-1 and TNKS-2 with IC50s of 259 nM and 1100 nM, respectively.TNKS-2-IN-1 has antimicrobial activity ag...
|
T8184 |
Fucosterol
|
17605-67-3
|
98.39%
|
|
Fucosterol is isolated from E. stolonifera with anti-diabetic, anti-adipogenic and anti-cancer activities. It regulates adipogenesis via modulation of PPARα and ...
|
T78157 |
PARP-1-IN-3
|
2976342-33-1
|
98.38%
|
|
PARP-1-IN-3 is a potent PARP-1 inhibitor that inhibits PARP-1 and PARP-2 with IC50 values of 0.25 nM and 2.34 nM, respectively.PARP-1-IN-3 has potential anti-inf...
|
T5S2358 |
Dehydrocorydaline
|
30045-16-0
|
98.36%
|
|
1. Dehydrocorydaline (13-Methylpalmatine) exerts anti-metastatic potential via suppression of MMPs and Bcl-2 signaling in NSC-LC cells. 2. Dehydrocorydaline stim...
|
T6224 |
Iniparib
|
160003-66-7
|
98.28%
|
|
Iniparib (BSI-201) (BSI-201) , a PARP1 inhibitor, exhibits potency in triple-negative breast Y (TNBC).
|
T9891 |
PARP1-IN-8
|
836640-15-4
|
98.26%
|
|
PARP1-IN-8 (N-(3-chlorophenyl)-3-(1-oxo-4-phenylphthalazin-2(1H)-yl)propanamide) is an effective inhibito of PARP1 (IC50 = 97 nM).
|
T6842 |
G007-LK
|
1380672-07-0
|
98.17%
|
|
G007-LK is a selective inhibitor of TNKS1 and TNKS2, with IC50s of 46 nM and 25 nM, respectively.
|
T61189 |
E7016
|
902128-92-1
|
98.16%
|
|
E7016 (GPI 21016) is an orally available PARP inhibitor. E7016 inhibits of DNA repair. E7016 can enhance tumor cell radiosensitivity in vitro and in vivo.
|
T2484 |
AZD-2461
|
1174043-16-3
|
98.11%
|
|
AZD2461 is a novel PARP inhibitor.
|
T6912 |
NU1025
|
90417-38-2
|
98.00%
|
|
NU1025 (NSC-696807) is a potent PARP inhibitor with IC50 of 400 nM.
|
T7439 |
3-Methoxybenzamide
|
5813-86-5
|
98%
|
|
3-Methoxybenzamide (3-MBA) is a competitive inhibitor of poly(ADP-ribose) synthetase.
|
T8150 |
Nudifloramide
|
701-44-0
|
98%
|
|
Nudifloramide (1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxamide) is one of the end degradation products of nicotinamide-adenine dinucleotide (NAD).
|
T5S1805 |
5,7-Dihydroxychromone
|
31721-94-5
|
98%
|
|
1. 5,7-Dihydroxychromone (5,7-Dihydroxy-4H-Chromen-4-One) isolated from DME is one of the active compounds that may contribute to regulate blood glucose levels. ...
|
T6339 |
AG14361
|
328543-09-5
|
97.65%
|
|
AG14361 is an effective inhibitor of PARP1 (Ki<5 nM).
|
T8296 |
5,7,4'-Trimethoxyflavone
|
5631-70-9
|
97.53%
|
|
5,7,4'-Trimethoxyflavone (4',5,7-Trimethoxyflavone) is isolated from Kaempferia parviflora (KP) which is a medicinal plant from Thailand.
|