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PARP

Poly (ADP-ribose) polymerase (PARP) is a family of proteins involved in a number of cellular processes such as DNA repair, genomic stability, and programmed cell death.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T62281 PARP-1-IN-2 684234-55-7 98.82%
PARP-1-IN-2
PARP-1-IN-2 is a potent PARP1 inhibitor that crosses the blood-brain barrier (IC50: 149 nM).PARP-1-IN-2 showed significant antiproliferative activity against the...
T67844 RBN-3143 2360853-16-1 98.64%
RBN-3143
RBN-3143 is a potent and inhibitor of NAD+-competitive catalytic PARP14 (IC50= 4 nM). RBN-3143 inhibits ADP-ribosylation mediated by PARP14 and stabilizes PARP14...
T9430 Venadaparib 1681017-83-3 98.47%
Venadaparib
Venadaparib (NOV140101) (IDX-1197) is a potent, selective and orally active PARP inhibitor with IC50s of 1.4 nM and 1.0 nM for PARP1 and PARP2, respectively. Ven...
T8964 G244-LM 1563007-08-8 98.46%
G244-LM
G244-LM is a potent and specific inhibitor of tankyrase 1/2. G244-LM inhibits Wnt signaling.
T72437 PARP1/2/TNKS1/2-IN-1 2243453-32-7 98.40%
PARP1/2/TNKS1/2-IN-1
PARP1/2/TNKS1/2-IN-1 is a multi-target inhibitor of PARP-1, PARP-2, TNKS1 and TNKS2.PARP1/2/TNKS1/2-IN-1 has potential anti-tumor activity and induces apoptosis....
T77675 TNKS-2-IN-1 4765-59-7 98.4%
TNKS-2-IN-1
TNKS-2-IN-1 is a TNKS-2 inhibitor.TNKS-2-IN-1 inhibits TNKS-1 and TNKS-2 with IC50s of 259 nM and 1100 nM, respectively.TNKS-2-IN-1 has antimicrobial activity ag...
T8184 Fucosterol 17605-67-3 98.39%
Fucosterol
Fucosterol is isolated from E. stolonifera with anti-diabetic, anti-adipogenic and anti-cancer activities. It regulates adipogenesis via modulation of PPARα and ...
T78157 PARP-1-IN-3 2976342-33-1 98.38%
PARP-1-IN-3
PARP-1-IN-3 is a potent PARP-1 inhibitor that inhibits PARP-1 and PARP-2 with IC50 values of 0.25 nM and 2.34 nM, respectively.PARP-1-IN-3 has potential anti-inf...
T5S2358 Dehydrocorydaline 30045-16-0 98.36%
Dehydrocorydaline
1. Dehydrocorydaline (13-Methylpalmatine) exerts anti-metastatic potential via suppression of MMPs and Bcl-2 signaling in NSC-LC cells. 2. Dehydrocorydaline stim...
T6224 Iniparib 160003-66-7 98.28%
Iniparib
Iniparib (BSI-201) (BSI-201) , a PARP1 inhibitor, exhibits potency in triple-negative breast Y (TNBC).
T9891 PARP1-IN-8  836640-15-4 98.26%
PARP1-IN-8 
PARP1-IN-8 (N-(3-chlorophenyl)-3-(1-oxo-4-phenylphthalazin-2(1H)-yl)propanamide) is an effective inhibito of PARP1 (IC50 = 97 nM).
T6842 G007-LK 1380672-07-0 98.17%
G007-LK
G007-LK is a selective inhibitor of TNKS1 and TNKS2, with IC50s of 46 nM and 25 nM, respectively.
T61189 E7016 902128-92-1 98.16%
E7016
E7016 (GPI 21016) is an orally available PARP inhibitor. E7016 inhibits of DNA repair. E7016 can enhance tumor cell radiosensitivity in vitro and in vivo.
T2484 AZD-2461 1174043-16-3 98.11%
AZD-2461
AZD2461 is a novel PARP inhibitor.
T6912 NU1025 90417-38-2 98.00%
NU1025
NU1025 (NSC-696807) is a potent PARP inhibitor with IC50 of 400 nM.
T7439 3-Methoxybenzamide 5813-86-5 98%
3-Methoxybenzamide
3-Methoxybenzamide (3-MBA) is a competitive inhibitor of poly(ADP-ribose) synthetase.
T8150 Nudifloramide 701-44-0 98%
Nudifloramide
Nudifloramide (1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxamide) is one of the end degradation products of nicotinamide-adenine dinucleotide (NAD).
T5S1805 5,7-Dihydroxychromone 31721-94-5 98%
5,7-Dihydroxychromone
1. 5,7-Dihydroxychromone (5,7-Dihydroxy-4H-Chromen-4-One) isolated from DME is one of the active compounds that may contribute to regulate blood glucose levels. ...
T6339 AG14361 328543-09-5 97.65%
AG14361
AG14361 is an effective inhibitor of PARP1 (Ki<5 nM).
T8296 5,​7,​4'-​Trimethoxyflavone 5631-70-9 97.53%
5,​7,​4'-​Trimethoxyflavone
5,7,4'-Trimethoxyflavone (4',5,7-Trimethoxyflavone) is isolated from Kaempferia parviflora (KP) which is a medicinal plant from Thailand.
PARP-1-IN-2
T62281
PARP-1-IN-2 is a potent PARP1 inhibitor that crosses the blood-brain barrier (IC50: 149 nM).PARP-1-IN-2 showed significant antiproliferative activity against the...
RBN-3143
T67844
RBN-3143 is a potent and inhibitor of NAD+-competitive catalytic PARP14 (IC50= 4 nM). RBN-3143 inhibits ADP-ribosylation mediated by PARP14 and stabilizes PARP14...
Venadaparib
T9430
Venadaparib (NOV140101) (IDX-1197) is a potent, selective and orally active PARP inhibitor with IC50s of 1.4 nM and 1.0 nM for PARP1 and PARP2, respectively. Ven...
G244-LM
T8964
G244-LM is a potent and specific inhibitor of tankyrase 1/2. G244-LM inhibits Wnt signaling.
PARP1/2/TNKS1/2-IN-1
T72437
PARP1/2/TNKS1/2-IN-1 is a multi-target inhibitor of PARP-1, PARP-2, TNKS1 and TNKS2.PARP1/2/TNKS1/2-IN-1 has potential anti-tumor activity and induces apoptosis....
TNKS-2-IN-1
T77675
TNKS-2-IN-1 is a TNKS-2 inhibitor.TNKS-2-IN-1 inhibits TNKS-1 and TNKS-2 with IC50s of 259 nM and 1100 nM, respectively.TNKS-2-IN-1 has antimicrobial activity ag...
Fucosterol
T8184
Fucosterol is isolated from E. stolonifera with anti-diabetic, anti-adipogenic and anti-cancer activities. It regulates adipogenesis via modulation of PPARα and ...
PARP-1-IN-3
T78157
PARP-1-IN-3 is a potent PARP-1 inhibitor that inhibits PARP-1 and PARP-2 with IC50 values of 0.25 nM and 2.34 nM, respectively.PARP-1-IN-3 has potential anti-inf...
Dehydrocorydaline
T5S2358
1. Dehydrocorydaline (13-Methylpalmatine) exerts anti-metastatic potential via suppression of MMPs and Bcl-2 signaling in NSC-LC cells. 2. Dehydrocorydaline stim...
Iniparib
T6224
Iniparib (BSI-201) (BSI-201) , a PARP1 inhibitor, exhibits potency in triple-negative breast Y (TNBC).
PARP1-IN-8 
T9891
PARP1-IN-8 (N-(3-chlorophenyl)-3-(1-oxo-4-phenylphthalazin-2(1H)-yl)propanamide) is an effective inhibito of PARP1 (IC50 = 97 nM).
G007-LK
T6842
G007-LK is a selective inhibitor of TNKS1 and TNKS2, with IC50s of 46 nM and 25 nM, respectively.
E7016
T61189
E7016 (GPI 21016) is an orally available PARP inhibitor. E7016 inhibits of DNA repair. E7016 can enhance tumor cell radiosensitivity in vitro and in vivo.
AZD-2461
T2484
AZD2461 is a novel PARP inhibitor.
NU1025
T6912
NU1025 (NSC-696807) is a potent PARP inhibitor with IC50 of 400 nM.
3-Methoxybenzamide
T7439
3-Methoxybenzamide (3-MBA) is a competitive inhibitor of poly(ADP-ribose) synthetase.
Nudifloramide
T8150
Nudifloramide (1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxamide) is one of the end degradation products of nicotinamide-adenine dinucleotide (NAD).
5,7-Dihydroxychromone
T5S1805
1. 5,7-Dihydroxychromone (5,7-Dihydroxy-4H-Chromen-4-One) isolated from DME is one of the active compounds that may contribute to regulate blood glucose levels. ...
AG14361
T6339
AG14361 is an effective inhibitor of PARP1 (Ki<5 nM).
5,​7,​4'-​Trimethoxyflavone
T8296
5,7,4'-Trimethoxyflavone (4',5,7-Trimethoxyflavone) is isolated from Kaempferia parviflora (KP) which is a medicinal plant from Thailand.
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TargetMol